Total flavonoids suppress lung cancer growth via the COX‑2‑mediated Wnt/β‑catenin signaling pathway

Han, Lei; Fang, Shu; Li, Guangtao; Wang, Minghuan; Yu, Rong

doi:10.3892/ol.2020.11271

Cited by 11 publications

(6 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The experimental results of cells and animal models have demonstrated that overexpression of COX-2 can inhibit tumor cell apoptosis, enhance cellular adhesion to achieve an invasive phenotype and promote tumor-induced angiogenesis (20,21). These theories have been confirmed in different types of tumors, including gastric (4), lung (22), pancreas (23), bladder (24), head and neck (25) and breast cancer (26). The present review discusses the effect of overexpressing COX-2 on the regulation of tumor growth and carcinogenesis.…”

Section: Roles Of Cox-2 In Cancermentioning

confidence: 92%

Interplay between cyclooxygenase‑2 and microRNAs in cancer (Review)

et al. 2021

View full text Add to dashboard Cite

Tumor-associated inflammation and aberrantly expressed biomarkers have been demonstrated to play crucial roles in the cancer microenvironment. Cyclooxygenase-2 (COX-2), a prominent inflammatory factor, is highly expressed in tumor cells and contributes to tumor growth, recurrence and metastasis. Overexpression of COX-2 may occur at both transcriptional and post-transcriptional levels. Thus, an improved understanding of the regulatory mechanisms of COX-2 can facilitate the development of novel antitumor therapies. MicroRNAs (miRNAs) are a group of small non-coding RNAs that act as translation repressors of target mRNAs, and play vital roles in regulating cancer development and progression. The present review discusses the association between miRNAs and COX-2 expression in different types of cancer. Understanding the regulatory role of miRNAs in COX-2 post-transcription can provide novel insight for suppressing COX-2 expression via gene silencing mechanisms, which offer new perspectives and future directions for the development of novel COX-2 selective inhibitors based on miRNAs. Contents 1. Introduction 2. Roles of COX-2 in cancer 3. Expression of miRNAs in cancer 4. Post-transcriptional COX-2 regulation is mediated by miRNAs 5. Upregulated expression of miRNAs by COX-2 selective inhibitor 6. Conclusions

show abstract

Section: Roles Of Cox-2 In Cancermentioning

confidence: 92%

Interplay between cyclooxygenase‑2 and microRNAs in cancer (Review)

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The ability of A549 cells to proliferate was decreased by TF in a dose-dependent manner; however, this effect was reversed by activating Wnt signaling via COX-2. Additionally, animal studies revealed that TF therapy greatly slowed the growth of mouse tumors, with a tumor inhibition rate of 64.07%, and increased the survival time of the animals ( Han et al, 2020 ).…”

Section: Intervention Of Natural Products On the Canonical Wnt Pathwa...mentioning

confidence: 99%

Natural compounds: Wnt pathway inhibitors with therapeutic potential in lung cancer

Shen,

Gao,

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

The Wnt/β-catenin pathway is abnormally activated in most lung cancer tissues and considered to be an accelerator of carcinogenesis and lung cancer progression, which is closely related to increased morbidity rates, malignant progression, and treatment resistance. Although targeting the canonical Wnt/β-catenin pathway shows significant potential for lung cancer therapy, it still faces challenges owing to its complexity, tumor heterogeneity and wide physiological activity. Therefore, it is necessary to elucidate the role of the abnormal activation of the Wnt/β-catenin pathway in lung cancer progression. Moreover, Wnt inhibitors used in lung cancer clinical trials are expected to break existing therapeutic patterns, although their adverse effects limit the treatment window. This is the first study to summarize the research progress on various compounds, including natural products and derivatives, that target the canonical Wnt pathway in lung cancer to develop safer and more targeted drugs or alternatives. Various natural products have been found to inhibit Wnt/β-catenin in various ways, such as through upstream and downstream intervention pathways, and have shown encouraging preclinical anti-tumor efficacy. Their diversity and low toxicity make them a popular research topic, laying the foundation for further combination therapies and drug development.

show abstract

“…Previous research found that therapy suppressed the Wnt and β‐catenin signaling pathway, which reduced cancer cell proliferation and elevated apoptosis. Additionally, antiproliferative and apoptotic activities are observed in the M. oleifera plant, which is related to the downregulation of the COX‐2, Wnt, and β‐catenin signaling pathways (Han et al., 2020).…”

Section: Mechanistic Role Of M Oleifera As An Anticancer Drugmentioning

confidence: 99%

Role of Moringa oleifera Lam. in cancer: Phytochemistry and pharmacological insights

et al. 2022

View full text Add to dashboard Cite

Moringa oleifera Lam. (M. oleifera), aka “Shigru,” “mother's best friend,” “miracle tree,” “horseradish tree,” “drumstick tree,” and “oil tree,” native of the sub‐Himalayan region of northern India, belongs to the Moringaceae family. The high nutritional value of M. oleifera makes it suitable for both nutritional and medicinal purposes. Because of its chemical constituents, M. oleifera is used to treat and combat malnutrition, especially in infants and nursing mothers. These days, herbal medicine and its phytocompound derivatives are also being recognized as effective complementary therapies for cancer treatment. So, in this study, M. oleifera is reviewed for its anticancer property. By thoroughly scanning the PubMed, Embase, SinoMed, and China National Knowledge Infrastructure databases, an extensive up‐to‐date report on its ethnomedicinal use, nutritional, phytochemistry, and pharmacotherapeutic potential is done. It has valuable nutrients such as vitamins, proteins, iron, calcium, antioxidants (flavonoids, carotenoids, and phenols) and ascorbic acid. Additionally, it is used as an antioxidant, anti‐inflammatory, antispasmodic, antimicrobial, anticancer, and antidiabetic agent. There are also concrete evidence that this plant's bioactive constituents, numerous extracts have a high biopotential in a number of cancer cells, through its antioxidative, anti‐inflammatory, antiproliferative, and cell cycle arresting properties. This extensive literature review will provide insights into several mechanisms and signaling pathways of its various phytoconstituents that can mitigate the growth of cancer cells in various experimental models, safety and toxicity concerns, and drug–drug interactions.

show abstract

Total flavonoids suppress lung cancer growth via the COX‑2‑mediated Wnt/β‑catenin signaling pathway

Cited by 11 publications

References 37 publications

Interplay between cyclooxygenase‑2 and microRNAs in cancer (Review)

Interplay between cyclooxygenase‑2 and microRNAs in cancer (Review)

Natural compounds: Wnt pathway inhibitors with therapeutic potential in lung cancer

Role of Moringa oleifera Lam. in cancer: Phytochemistry and pharmacological insights

Contact Info

Product

Resources

About