Cardioprotective effect of water and ethanol extract of Salvia miltiorrhiza in an experimental model of myocardial infarction

Zhou, Ran; He, Li-Fen; Li, Yongjie; Shen, Yi Wen; Ruo-bing, Chao; Du, Jun-Rong

doi:10.1016/j.jep.2011.11.030

Cited by 53 publications

(23 citation statements)

References 29 publications

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“…There was improvement in the levels of Cx43 and tissue antioxidant enzymes indicating a possible mitigation via reduction of oxidative stress (Tang et al, ). In another similar study, aqueous ethanol solution extract of this novel Chinese herb could potentially abrogate ISP‐induced cardiac damage (Zhou et al, ). A recent in vitro study showed the reduction of H 2 O 2 ‐induced oxidative damage in H9c2 cells by inhibiting apoptosis, showing cardioprotective proof of depsides isolated from S .…”

Section: Natural Products and Their Pharmacological Potential In Allementioning

confidence: 91%

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Allawadhi

Khurana

Sayed

et al. 2018

Phytotherapy Research

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Heart is the most active and incumbent organ of the body, which maintains blood flow, but due to various pathological reasons, several acute and chronic cardiac complications arise out of which myocardial infarction is one of the teething problems. Isoproterenol (ISP)-induced myocardial ischemia is a classical model to screen the cardioprotective effects of various pharmacological interventions. Phytochemicals present a novel option for treating various human maladies including those of the heart. A large number of plant products and their active ingredients have been screened for efficacy in ameliorating ISP-induced myocardial ischemia including coriander, curcumin, Momordica, quercetin, and Withania somnifera. These phytochemicals constituents may play key role in preventing disease and help in cardiac remodeling. Reactive oxygen species scavenging, antiinflammatory, and modulation of various molecular pathways such as Nrf2, NFкB, p-21 activated kinase 1 (PAK1), and p-smad2/3 signaling modulation have been implicated behind the claimed protection. In this review, we have provided a focused overview on the utility of ISP-induced cardiotoxicity, myocardial ischemia, and cardiac fibrosis for preclinical research. In addition, we have also surveyed molecular mechanism of various plant-based interventions screened for cardioprotective effect in ISP-induced cardiotoxicity, and their probable mechanistic profile is summarized.

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Section: Natural Products and Their Pharmacological Potential In Allementioning

confidence: 91%

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Allawadhi

Khurana

Sayed

et al. 2018

Phytotherapy Research

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“…Protocatechuic acid is its major chemical constituent. Isoproterenol induced acute myocardial infarction in rats showed positive treatment effects with the extracts of Salvia miltiorrhiza [26] (29.76 or 59.52 mg/kg). Isoproterenol-treated rats showed reductions in left ventricular systolic pressure as well as in maximum and minimum rate of developed left ventricular pressure, together with an increase in left ventricular end-diastolic pressure.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

A Review on Protocatechuic Acid and Its Pharmacological Potential

2014

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Flavonoids and polyphenols are heterocyclic molecules that have been associated with beneficial effects on human health, such as reducing the risk of various diseases like cancer, diabetes, and cardiovascular and brain diseases. Protocatechuic acid (PCA) is a type of widely distributed naturally occurring phenolic acid. PCA has structural similarity with gallic acid, caffeic acid, vanillic acid, and syringic acid which are well-known antioxidant compounds. More than 500 plants contain PCA as active constituents imparting various pharmacological activity and these effects are due to their antioxidant activities, along with other possible mechanisms, such as anti-inflammatory properties and interaction with several enzymes. Over the past two decades, there have been an increasing number of publications on polyphenols and flavonoids, which demonstrate the importance of understanding the chemistry behind the antioxidant activities of both natural and synthesized compounds, considering the benefits from their dietary ingestion as well as pharmacological use. This work aims to review the pharmacological effects of PCA molecules in humans and the structural aspects that contribute to these effects.

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“…In addition, Danshensu (1 and 10 µM) [88] and the extract of S. miltiorrhiza (29.76 or 59.52 mg/kg for 5 days by gavage) [89] treatment contributed to the recovery of cardiac function after MI, and the tolerance of heart against MI injury by improving coronary flow, heart rate and left ventricular developed pressure, and the recovery of ± dp/dt max as well as reducing infarct sizes via inhibiting oxidative stress through regualting Akt/extracellular signal-regulated kinase (ERK) 1/2/nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathways in isolated rat hearts MI model.…”

Section: Effects Of S Miltiorrhiza and Its Isolated Compounds On Thementioning

confidence: 99%

Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases

Wang

Liu

et al. 2017

CPD

195

125

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Salvia miltiorrhiza Bunge, also known as Danshen in Chinese, has been widely used to treat cardiovascular diseases (CVD) in China and other Asia countries. Here, we summarize literatures of the historical traditional Chinese medicine (TCM) interpretation of the action of Salvia miltiorrhiza, its use in current clinical trials, its main phytochemical constituents and its pharmacological findings by consulting Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, and the Web of Science Databases. Since 2000, 39 clinical trials have been identified that used S. miltiorrhiza in TCM prescriptions alone or with other herbs for the treatment of patients with CVD. More than 200 individual compounds have been isolated and characterized from S. miltiorrhiza, which exhibited various pharmacological activities targeting different pathways for the treatment of CVD in various animal and cell models. The isolated compounds may provide new perspectives in alternative treatment regimes and reveal novel chemical scaffolds for the development of anti-CVD drugs. Meanwhile, there are also some rising concerns of the potential side effects and drug-drug interactions of this plant. The insights gained from this study will help us to better understanding of the actions of this herb for management of cardiovascular disorders. As an herb of red root, S. miltiorrhiza will act as a potential red light to prevent the development of CVD.

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Cardioprotective effect of water and ethanol extract of Salvia miltiorrhiza in an experimental model of myocardial infarction

Cited by 53 publications

References 29 publications

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

A Review on Protocatechuic Acid and Its Pharmacological Potential

Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases

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