Cardioprotective activity of Cladosiphon okamuranus fucoidan against isoproterenol induced myocardial infarction in rats

Thomes, Paul; Rajendran, Murugan; Pasanban, Balu; Rengasamy, Ramasamy

doi:10.1016/j.phymed.2010.06.006

Cited by 77 publications

(41 citation statements)

References 30 publications

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“…Additionally, several investigators have reported that water soluble fractions of seaweeds or isolated algal polysaccharides induce hypocholesterolemic and antihypertensive effects in experimental animals [131,195,196]. Indeed, sodium alginate and fucoidan were found to decrease serum cholesterol levels in vivo [132,133,197]. …”

Section: Potential To Reduce Prevalence Of Chronic Diseasesmentioning

confidence: 99%

Marine Bioactives as Functional Food Ingredients: Potential to Reduce the Incidence of Chronic Diseases

2011

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The marine environment represents a relatively untapped source of functional ingredients that can be applied to various aspects of food processing, storage, and fortification. Moreover, numerous marine-based compounds have been identified as having diverse biological activities, with some reported to interfere with the pathogenesis of diseases. Bioactive peptides isolated from fish protein hydrolysates as well as algal fucans, galactans and alginates have been shown to possess anticoagulant, anticancer and hypocholesterolemic activities. Additionally, fish oils and marine bacteria are excellent sources of omega-3 fatty acids, while crustaceans and seaweeds contain powerful antioxidants such as carotenoids and phenolic compounds. On the basis of their bioactive properties, this review focuses on the potential use of marine-derived compounds as functional food ingredients for health maintenance and the prevention of chronic diseases.

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Section: Potential To Reduce Prevalence Of Chronic Diseasesmentioning

confidence: 99%

Marine Bioactives as Functional Food Ingredients: Potential to Reduce the Incidence of Chronic Diseases

2011

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“…, a heart attack) induced by isoproterenol [52]. Oral dosing of Cladosiphon derived fucoidan at 150 mg/kg for 7 days had a marked protective effect on the sequelae of the infarction, including lowering cardiac enzymes and lipid profiles.…”

Section: Inflammation and Fibrosismentioning

confidence: 99%

Therapies from Fucoidan; Multifunctional Marine Polymers

Fitton¹

2011

Marine Drugs

308

225

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Published research on fucoidans increased three fold between 2000 and 2010. These algal derived marine carbohydrate polymers present numerous valuable bioactivities. This review discusses the role for fucoidan in the control of acute and chronic inflammation via selectin blockade, enzyme inhibition and inhibiting the complement cascade. The recent data on toxicology and uptake of fucoidan is detailed together with a discussion on the comparative activities of fractions of fucoidan from different sources. Recent in vivo, in vitro and clinical research related to diverse clinical needs is discussed. Targets include osteoarthritis, kidney and liver disease, neglected infectious diseases, hemopoietic stem cell modulation, protection from radiation damage and treatments for snake envenomation. In recent years, the production of well characterized reproducible fucoidan fractions on a commercial scale has become possible making therapies from fucoidan a realizable goal.

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“…Although a great progress in the treatment of MI had been achieved by administration of modern drugs, they are mostly accompanied with many adverse effects (Thomes, Rajendran, Pasanban, & Rengasamy, 2010). The search for indigenous cardioprotective agents for MI still needs a medical breakthrough.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, there has been a growing interest in developing phytopharmaceuticals from medicinal plants to cope with this condition, owing to their non-addictive and non-toxic nature. Some plant products have been found to be more effective in the management of MI throught augmentation of myocardial antixoidants, such as Danshensu (Tang et al, 2011), Rhodobryum roseum extract (Hu et al, 2009), Cladosiphon okamuranus fucoidan (Thomes et al, 2010), 20(S)-panaxadiol (Wang, Meng, Zhang, Bi, & Jiang, 2010), and so on. Salvia miltiorrhiza, commonly known as DanShen, is one of the most famous traditional Chinese herbal medicines used for the treatment of ischemic cardiovascular diseases, containing phenolic compounds and potent antioxidant moieties (Ji, Tan, Zhu, Linz, & Zhu, 2003;Ji et al, 2004;Sun et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of a polysaccharide from Salvia miltiorrhiza on isoproterenol (ISO)-induced myocardial injury in rats

Zhao

Huang

Song

et al. 2015

Carbohydrate Polymers

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Cardioprotective activity of Cladosiphon okamuranus fucoidan against isoproterenol induced myocardial infarction in rats

Cited by 77 publications

References 30 publications

Marine Bioactives as Functional Food Ingredients: Potential to Reduce the Incidence of Chronic Diseases

Marine Bioactives as Functional Food Ingredients: Potential to Reduce the Incidence of Chronic Diseases

Therapies from Fucoidan; Multifunctional Marine Polymers

Protective effect of a polysaccharide from Salvia miltiorrhiza on isoproterenol (ISO)-induced myocardial injury in rats

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