Cardiac tissue regeneration: A preliminary study on carbon‐based nanotubes gelatin scaffold

Cabiati, Manuela; Vozzi, Federico; Gemma, Federica; Montemurro, Francesca; Maria, Carmelo De; Vozzi, Giovanni; Domenici, Claudio; Ry, Silvia Del

doi:10.1002/jbm.b.34056

Cited by 22 publications

(6 citation statements)

References 45 publications

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“…Functionalized MWCNTs with carbodihydrazide improved electrical and mechanical properties of the hydrogel, leading to an increase in cell proliferation and expression of Cx43[77]. More recently, Cabiati et al incorporated different concentrations of SW-CNTs into gelatin-based genipin cross-linked scaffolds and observed overexpression of cardiac markers in cardiomyoblasts[78].…”

mentioning

confidence: 99%

Electrically conductive nanomaterials for cardiac tissue engineering

Ashtari

Nazari

et al. 2019

Advanced Drug Delivery Reviews

162

121

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Patient deaths resulting from cardiovascular diseases are increasing across the globe, posing the greatest risk to patients in developed countries. Myocardial infarction, as a result of inadequate blood flow to the myocardium, results in irreversible loss of cardiomyocytes which can lead to heart failure. A sequela of myocardial infarction is scar formation that can alter the normal myocardial architecture and result in arrhythmias. Over the past decade, a myriad of tissue engineering approaches has been developed to fabricate engineered scaffolds for repairing cardiac tissue. This paper highlights the recent application of electrically conductive nanomaterials (carbon and gold-based nanomaterials, electroactive polymers) to the development of scaffolds for cardiac tissue engineering. Moreover, this work summarizes the effects of these nanomaterials on cardiac cell behavior such as proliferation and migration, as well as cardiomyogenic differentiation in stem cells.

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mentioning

confidence: 99%

Electrically conductive nanomaterials for cardiac tissue engineering

Ashtari

Nazari

et al. 2019

Advanced Drug Delivery Reviews

162

121

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“…Furthermore, GNP can form a permanent crosslink between two polymers through intra- and inter-molecular crosslinking reactions, producing scaffolds with higher biomechanical properties in the concentration range of 0.1–0.5% ( Turner et al, 2017 ; Krishnakumar et al, 2018 ; Aubert-Viard et al, 2019 ; Sulistiawati Rusyanti et al, 2019 ; Elliott et al, 2015 ; Hobbs et al, 2018 ). The porous microstructure and higher modulus and mechanical strength will lead to an acceptable in vitro biocompatibility ( Figure 5 ) ( Cabiati et al, 2018 ; Gattazzo et al, 2018 ; Nyambat et al, 2020 ). Moreover, it ensures adequate nutrient and oxygen diffusion during skin regeneration as well as cell penetration to support cell proliferation and vascularization.…”

Section: Genipin As Natural-based Crosslinking Compoundmentioning

confidence: 99%

Genipin-Crosslinking Effects on Biomatrix Development for Cutaneous Wound Healing: A Concise Review

Nike

Fadilah

Sallehudin

et al. 2022

Front. Bioeng. Biotechnol.

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Split skin graft (SSG), a standard gold treatment for wound healing, has numerous limitations such as lack of fresh skin to be applied, tedious process, severe scarring, and keloid formation followed by higher risks of infection. Thus, there is a gap in producing polymeric scaffolds as an alternative for wound care management. Bioscaffold is the main component in tissue engineering technology that provides porous three-dimensional (3D) microarchitecture for cells to survive. Upon skin tissue reconstruction, the 3D-porous structure ensures sufficient nutrients and gaseous diffusion and cell penetration that improves cell proliferation and vascularization for tissue regeneration. Hence, it is highly considered a promising candidate for various skin wound healing applications. To date, natural-based crosslinking agents have been extensively used to tailor the physicochemical and mechanical properties of the skin biomatrix. Genipin (GNP) is preferable to other plant-based crosslinkers due to its biological activities, such as antiinflammatory and antioxidant, which are key players to boost skin wound healing. In addition, it has shown a noncytotoxic effect and is biocompatible with human skin cells. This review validated the effects of GNP in biomatrix fabrication for skin wound healing from the last 7 years of established research articles and stipulated the biomaterial development-scale point of view. Lastly, the possible role of GNP in the skin wound healing cascade is also discussed. Through the literature output, it can be concluded that GNP has the capability to increase the stability of biomatrix and maintain the skin cells viability, which will contribute in accelerating wound healing.

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“…Apart from the mechanical benefits of carbon materials for reinforcing polymers, their addition to the polymeric matrix can lead to conductive properties for enhanced transmission of electrical signals between the cells. Electrically conductive chitosan/carbon scaffolds [ 126 ] and carbon‐based nanotube–gelatin scaffolds [ 127 ] for cardiac tissue engineering have been proposed. Similar combinations may be used for load bearing constructs with self‐monitoring capabilities.…”

Section: Fabrication Strategies Of Carbon‐based Materials For Articul...mentioning

confidence: 99%

Carbon‐Based Materials for Articular Tissue Engineering: From Innovative Scaffolding Materials toward Engineered Living Carbon

Islam

Lantada

Mager

et al. 2021

Adv Healthcare Materials

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Carbon materials constitute a growing family of high-performance materials immersed in ongoing scientific technological revolutions. Their biochemical properties are interesting for a wide set of healthcare applications and their biomechanical performance, which can be modulated to mimic most human tissues, make them remarkable candidates for tissue repair and regeneration, especially for articular problems and osteochondral defects involving diverse tissues with very different morphologies and properties. However, more systematic approaches to the engineering design of carbon-based cell niches and scaffolds are needed and relevant challenges should still be overcome through extensive and collaborative research. In consequence, this study presents a comprehensive description of carbon materials and an explanation of their benefits for regenerative medicine, focusing on their rising impact in the area of osteochondral and articular repair and regeneration. Once the state-of-the-art is illustrated, innovative design and fabrication strategies for artificially recreating the cellular microenvironment within complex articular structures are discussed. Together with these modern design and fabrication approaches, current challenges, and research trends for reaching patients and creating social and economic impacts are examined. In a closing perspective, the engineering of living carbon materials is also presented for the first time and the related fundamental breakthroughs ahead are clarified.

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Cardiac tissue regeneration: A preliminary study on carbon‐based nanotubes gelatin scaffold

Cited by 22 publications

References 45 publications

Electrically conductive nanomaterials for cardiac tissue engineering

Electrically conductive nanomaterials for cardiac tissue engineering

Genipin-Crosslinking Effects on Biomatrix Development for Cutaneous Wound Healing: A Concise Review

Carbon‐Based Materials for Articular Tissue Engineering: From Innovative Scaffolding Materials toward Engineered Living Carbon

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