Cardiac Rehabilitation is Associated With an Improvement in C-Reactive Protein Levels in Both Men and Women With Cardiovascular Disease

Caulin–Glaser, Teresa; Falko, James M.; Hindman, Lisa; M, La Londe; Snow, Richard

doi:10.1097/00008483-200511000-00003

Cited by 39 publications

(34 citation statements)

References 13 publications

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“…9 Similar results were found in the study by Caulin-Glaser and Attarbashi Moghadam. 10,11 In present study, we also found that serum hs-CRP levels decreased significantly following cardiac rehabilitation, as it has been reported previously. We found no study available evaluating the effects of exercise on salivary hs-CRP in patients with CAD.…”

supporting

confidence: 90%

“…However, our findings of nonsignificant association between hs-CRP and anthropometric measures of obesity is in agreement with previous results showing that exercise training could mitigate the hs-CRP levels independent of changes in body weight or body mass index. 2,[9][10][11] In the present study, serum hs-CRP levels were reduced by 36% after aerobic exercise training without any changes in central obesity parameters, indicating that other mechanisms leading to the anti-inflammatory effect of exercise.…”

Section: Discussionmentioning

confidence: 66%

“…7 Salivary CRP levels have been used to assess whether CRP determination in saliva samples could be utilized as a way to detect inflammation, and as an alternative approach to evaluate disease risk and monitoring the response to treatment. 8 Previous studies demonstrated that the plasma levels of hs-CRP are significantly decreased after exercise training program, 3,[9][10][11][12] suggesting that rehabilitation program may develop an anti-inflammatory reaction. However, reports showing the levels of hs-CRP in saliva before, during and after cardiac rehabilitation are lacking.…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11] The majority of these studies have reported that exercise training in coronary patients is associated with considerable reduction in serum hs-CRP levels. In the study by Millani et al reduction of serum hs-CRP concentrations was observed after 3-month exercise training and cardiac rehabilitation.…”

mentioning

confidence: 99%

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The Effects of Phase III Cardiac Rehabilitation in Serum and Salivary Hs-CRP and Anthropometric Measurements in Patients with Coronary Artery Disease

Jamshidpour

Moghadam

Vasaghi‐Gharamaleki

et al. 2013

The Journal of Contemporary Dental Practice

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Aim: Cardiac rehabilitation is a key part in the treatment of coronary artery disease (CAD) by its anti-inflammatory effects. However, the effect of exercise training programs on salivary concentrations of high-sensitivity C-reactive protein (hs-CRP) in patients with coronary artery disease has not been well studied. The objective of this study was to evaluate the effect of phase III cardiac rehabilitation on serum and salivary levels of hs-CRP, in relation to the anthropometric measurements of obesity and the relationship between salivary and serum levels of hs-CRP in CAD male patients. Materials and methods:Forty male volunteers (45-75 years) with CAD participated in 6 to 8 weeks of moderate intensity aerobic exercise training consisting of 45 minutes sessions of treadmill, stationary bicycle and arm ergometer. Anthropometric measurements of obesity, serum level of hs-CRP, stimulated and nonstimulated salivary level of hs-CRP were measured at the beginning, in the middle and at the end of exercise sessions.Results: All anthropometric measurements increased (p < 0.05) following cardiac rehabilitation except waist-hip ratio. Serum hs-CRP level reduced by 36% independent to the anthropometric measurements changes. Stimulated and nonstimulated salivary hs-CRP level decreased 68 and 54%, respectively, after 24 sessions of cardiac rehabilitation. Nonstimulated salivary hs-CRP levels correlated to serum levels of hs-CRP at baseline and after 24 sessions (p < 0.05). Conclusion:Phase III cardiac rehabilitation seems to be effective to improve serum and salivary hs-CRP concentrations independent of anthropometric measurements.Clinical significance: Nonstimulated salivary hs-CRP measurement could be a surrogate for blood measurement of hs-CRP during cardiac rehabilitation in male patients with CAD.

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supporting

confidence: 90%

Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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The Effects of Phase III Cardiac Rehabilitation in Serum and Salivary Hs-CRP and Anthropometric Measurements in Patients with Coronary Artery Disease

Jamshidpour

Moghadam

Vasaghi‐Gharamaleki

et al. 2013

The Journal of Contemporary Dental Practice

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“…They found a significant reduction in CRP after the 3-month intervention in CAD patients with and without metabolic syndrome [296], in weight gainers and losers [295], and in patients with or without statin therapy [295]. This data was later confirmed by Caulin-Glaser et al [297], who reported a consistent reduction of CRP in patients who showed no improvement or an increase in triglycerides, body mass index, and weight. Others [289,290,298] also observed the statins and weight loss-independent effects of exercise on CRP and other markers of inflammation.…”

Section: Effects Of Regular Physical Exercise On Crp and Other Inflammentioning

confidence: 83%

Effects of Physical Exercise on Inflammatory Markers of Atherosclerosis

Pinto¹,

Raimondo

Tuttolomondo³

et al. 2012

CPD

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Abstract:It is well established that physically fit individuals have a reduced risk of developing CVD (cardiovascular disease) and other age-related chronic disorders. Regular exercise is an established therapeutic intervention with an enormous range of benefits. Chronic low-grade systemic inflammation may be involved in atherosclerosis, diabetes and in pathogenesis of several chronic pathological conditions; recent findings confirm that physical activity induces an increase in the systemic levels of a number of cytokines and chemokines with anti-inflammatory properties. The possibility that regular physical exercise exerts anti-inflammation activity, being the interaction between contracting muscle and the other tissues and the circulating cells mediated through signals transmitted by "myokines" produced with muscle contractions. To date the list of myokines includes IL-6, IL-8, and IL-15. During muscle contractions are also released IL1receptor antagonis and sTNF-R, molecules that contribute to provide anti-inflammatory actions.Nevertheless discrepancies, analysis of available researches seem to confirm the efficacy of regular physical training as a nonpharmacological therapy having target chronic low-grade inflammation. Given this, physical exercise could be considerate a useful weapon against local vascular and systemic inflammation in atherosclerosis. Several mechanisms explain the positive effect of chronic exercise, nevertheless, these mechanisms do not fully enlighten all pathways by which exercise can decrease inflammation and endothelial dysfunction, and hence modulate the progression of the underlying disease progress.

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Lifestyle as a Risk Factor for Metabolic Syndrome and Neurological Disorders

Farooqui

2013

Metabolic Syndrome

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Cardiac Rehabilitation is Associated With an Improvement in C-Reactive Protein Levels in Both Men and Women With Cardiovascular Disease

Abstract: Participation in CR was associated with a marked improvement of cardiac risk factors and appears to independently decrease the level of CRP regardless of gender, age, or presence of metabolic syndrome.

Cited by 39 publications

References 13 publications

The Effects of Phase III Cardiac Rehabilitation in Serum and Salivary Hs-CRP and Anthropometric Measurements in Patients with Coronary Artery Disease

The Effects of Phase III Cardiac Rehabilitation in Serum and Salivary Hs-CRP and Anthropometric Measurements in Patients with Coronary Artery Disease

Effects of Physical Exercise on Inflammatory Markers of Atherosclerosis

Lifestyle as a Risk Factor for Metabolic Syndrome and Neurological Disorders

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