Cardiac myxosarcoma with thoracic spinal metastasis

Kimura, Mitsuhiro; Kikuchi, Chizuo; Takahashi, Yoshiki; Kanazawa, Hiroshi; Nakazawa, Satoshi

doi:10.1007/s11748-013-0261-1

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…Although the number of reported cardiac sarcoma cases metastatic to the brain is too small to suggest a mechanism of spread of the neoplasm, it is possible that haematogenous spread with intracerebral invasion is a common route of dissemination [4]. A few cases of spinal metastasis, even a case of brain stem metastasis, have also been reported in the literature [5,7], but we did not find any case describing cerebellar metastasis. The difficulty in long-term treatment of cardiac sarcoma is prevention of metastasis and local recurrence [3].…”

Section: Discussionmentioning

confidence: 70%

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Cerebellar and bone metastasis from primary cardiac sarcoma: an unusual case

et al. 2015

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Dear Editor, Primary cardiac tumours are uncommon [3]. The incidence in autopsy series ranged from 0.001 to 0.3 % [5]. About threequarters of these are benign, the other quarter malignant [6]. Because of the few reported cases and poor prognosis of primary cardiac sarcomas, the metastatic potential and behaviour of these tumours are not fully understood [4].We present the case of a 28-year-old male who came acutely to our hospital because of congestive heart failure. He required an emergent thoracotomy to resection of a left atrium mass. The surgical excision was complete. The histological examination showed a diffusely infiltrating mass compatible with a pleomorphic high-grade sarcoma. After heart surgery the patient had chemotherapy and local radiation. One year later he was admitted to the neurosurgical department because of a 10-day history of headache, vomiting and instability. The cranial magnetic resonance imaging revealed a right cerebellar mass with ring contrast-enhancing and surrounding edema that compressed the fourth ventricle. The patient underwent an infratentorial craniectomy with complete resection of the lesion. Histopathologically the tumour was mainly composed of pleomorphic malignant cells with irregular nuclei and prominent nucleoli, areas of necrosis and a significant degree of anaplasia. Tumour cells were inmunoreative for vimentin, desmin, smooth muscle actin and neuronal specific enolase and negative for myo D1, CD99, CD68 and AE1/AE3. It was compatible with a metastasis of pleomorphic undifferentiated sarcoma with a positive muscle marker, suggesting leiomyosarcoma differentiation. The proliferation marker Ki67 was 60 %. The patient had subsequent chemotherapy and radiotherapy. Four years after complaining of left hip pain, the patient underwent hip magnetic resonance imaging, which revealed a well-demarcated mass at the left femoral neck, with heterogeneous gadolinium enhancement. There were no other bone, cardiac or brain lesions in the total body scan. He received palliative radiotherapy for the initial management of pain. Then a left proximal femoral resection and total hip replacement were performed. The histological analysis confirmed an osteolytic lesion composed of atypical giant undifferentiated cells compatible with a metastasis from cardiac pleomorphic sarcoma. More than 6 years after the initial diagnosis, the patient remains alive and healthy. DiscussionPrimary cardiac tumours represent between 5 % and 10 % of all cardiac tumours. The majority are benign, with only a small portion being malignant. Undifferentiated pleomorphic sarcoma is extremely rare. Most have been published as single case reports [6] and minimal epidemiological data have been collected. Usually, they present in young patients and have a poor prognosis, often fatal, considerably worse than that of * Aida Antuña Ramos

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Section: Discussionmentioning

confidence: 70%

“…The incidence in autopsy series ranged from 0.001 to 0.3 % [5]. About threequarters of these are benign, the other quarter malignant [6].…”

mentioning

confidence: 99%

Cerebellar and bone metastasis from primary cardiac sarcoma: an unusual case

et al. 2015

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“…O mixossarcoma é uma neoplasia de ocorrência pouco frequente em cães, correspondendo a 0,5% dos casos de tumores cutâneos e 2,3% dos casos de sarcomas de tecidos moles de cães e gatos [14,15]. Apesar de normalmente ser encontrado na forma subcutânea devido a sua origem fibroblástica, há relatos do tumor originando-se no mesentério, vísceras e olhos [1,6,9,11,18].…”

Section: Discussionunclassified

Radiographic, Citomorphological, and Histochemical Characterization of the Skin Mixosarcoma in a Bitch

Sampaio

Silva

Lima

et al. 2018

Acta Scientiae. Vet.

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Background: Myxosarcoma is a malignant mesenchymal tumor that arises from fibroblasts and is characterized by a low frequency of metastases, which in turn are highly invasive locally. Even though this type of tumor is relatively well documented, its radiographic and cytomorphological aspects are rarely described. The present report describes a case of cutaneous myxosarcoma in a female dog, and highlights radiographic, cytological, and histopathological findings. Case: An 11-year-old female mongrel dog was examined at the Veterinary Hospital of Federal University of Paraíba. The patient exhibited a firm 20 cm-wide mass covered by skin in the left abdominal wall, a lesion that had been developing for approximately five months. During the clinical examination, the patient demonstrated apathy and difficulty to stand. Initially, exams requested included radiography, ultrasonography, and cytological analysis of biopsy material obtained by fine needle aspiration (FNA). Radiography and ultrasonography were used to investigate the extent of the tumor, as well as invasion of other organs. Radiography revealed that the tumor was radiopaque, homogeneous, and restricted to the skin and subcutaneous tissue; no metastases were observed. Cytological examination allowed observation of a hypocellular sample predominantly composed of isolated pleomorphic fusiform cells embedded in a discrete homogeneous eosinophilic material. These cells exhibited a moderate, well delimited cytoplasm with multiple vacuoles; the end opposed to the nucleus was slender. Their nuclei were eccentric, with punctate chromatin and inconspicuous nucleoli. The patient was subjected to complete surgical excision of the tumor, and the surgical piece was submitted to histopathological examination. The mass was described as single and firm; its dimensions were 20 cm x 16 cm x 15 cm, and its weight was 2.5 kg. Fragments were processed and stained with hematoxylin and eosin (HE) or alcian blue (AB) for evaluation by optical microscopy. Histopathology revealed an infiltrative, expansive, non-encapsulated mass characterized by mesenchymal cells ranging from elongated to stellate. These cells were well individualized, had a scant to moderate cytoplasm, indistinct and slightly eosinophilic borders, and a nucleus that varied from oval to stellate in shape, with highly condensed chromatin and inconspicuous nucleoli. AB-stained specimens exhibited an extensive myxomatous matrix stained in blue, which was intertwined with neoplastic cells. Therefore, the diagnosis of cutaneous myxosarcoma was confirmed. Discussion: The diagnosis of myxosarcoma was established on the basis of radiographic and cytological findings, and it was confirmed by histopathological examination, which sped up decision-making and completion of the case. Tumors of this group are not accompanied by paraneoplastic syndromes; however, given the size and weight of the mass under study, pain may have been the triggering factor of the apathy and difficulty to stand observed here. The age of the patient and t...

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“…6) Many kinds of rare cardiac tumors are reported annually in medical journals. 7,8) Cardiac SFT is still a tumor which is reported just by finding its existence.…”

Section: Incidencementioning

confidence: 99%

Primary Cardiac Solitary Fibrous Tumors

Taguchi

2015

ATCS

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Cardiac myxosarcoma with thoracic spinal metastasis

Cited by 3 publications

References 9 publications

Cerebellar and bone metastasis from primary cardiac sarcoma: an unusual case

Cerebellar and bone metastasis from primary cardiac sarcoma: an unusual case

Radiographic, Citomorphological, and Histochemical Characterization of the Skin Mixosarcoma in a Bitch

Primary Cardiac Solitary Fibrous Tumors

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