Carcinosarcoma of urothelial organs: Sequential involvement of urinary bladder, ureter, and renal pelvis

Orsatti, Giulia; Corgan, Francis J.; Goldberg, Steven A.

doi:10.1016/0090-4295(93)90579-y

Cited by 28 publications

(18 citation statements)

References 11 publications

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“…On the contrary, a variable but definite fraction of the malignant mesenchymal cells have immunohistochemical and ultrastructural characteristics of epithelial cells and lack, for instance, vimentin expression. Cases with temporal evolution from low-grade transitional cell carcinoma to a tumour with a sarcomatous stroma have been reported [14]. Also, carcinosarcomas and sarcomatoid carcinomas show a comparable tumour biology, as both are observed in the same age group as conventional urothelial carcinoma and as there is no survival difference between patients with carcinosarcoma and those with sarcomatoid carcinoma of the urothelial tract [4].…”

Section: Discussionmentioning

confidence: 99%

Biphasic sarcomatoid carcinoma (carcinosarcoma) of the renal pelvis with heterologous chondrogenic differentiation

et al. 2000

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A case of a man with biphasic sarcomatoid carcinoma of the right kidney with chondrosarcomatous foci and with invasion of the pelvic mucosa and submucosa into the peripelvic adipose tissue is presented. In situ carcinoma of the urothelium of the right renal pelvis and proximal ureter was also noted. Comments on the nomenclature of malignant tumours with apparently mixed carcinomatous and sarcomatous phenotypes and a hypothesis on the histogenesis of these tumours are presented. Cytokeratin and p53 protein expression patterns, and the results of angiogenesis quantification are consistent with an epithelial-to-mesenchymal conversion induced by the stroma.

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Section: Discussionmentioning

confidence: 99%

Biphasic sarcomatoid carcinoma (carcinosarcoma) of the renal pelvis with heterologous chondrogenic differentiation

et al. 2000

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“…The previously underrecognized high incidence of multiple primaries in patients with carcinosarcoma of the urinary bladder suggests a common underlying mechanism or pathway of carcinogenesis. Although the potential nonrandom association and causal relationship between carcinosarcoma and other neoplasms remains unknown, field cancerization, cancer stem cell, or patient screening effect may account for the relatively frequent association of multiple primaries in patients with urogenital tumors [21–23]. …”

Section: Discussionmentioning

confidence: 99%

Clinical Features of Sarcomatoid Carcinoma (Carcinosarcoma) of the Urinary Bladder: Analysis of 221 Cases

Wang

LaGrange

et al. 2010

Sarcoma

107

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Background. Urinary bladder sarcomatoid carcinoma (carcinosarcoma) is rare. The objective of this study was to examine the epidemiology, natural history, and prognostic factors of urinary bladder carcinosarcoma using population-based registry. Methods. The Surveillance, Epidemiology, and End Results (SEER) Program database was used to identify cases by tumor site and histology codes. The association between clinical and demographic characteristics and long-term survival was examined. Results. A total of 221 histology confirmed cases were identified between 1973 and 2004, this accounted for approximately 0.11% of all primary bladder tumors during the study period. Median age of the patients was 75 years (range 41–96). Of the patients with a known tumor stage (N = 204), 72.5% had a regional or distant stage; 98.4% of patients with known histology grade (N = 127), had poorly or undifferentiated histology. Multiple primary tumors were indentified in about 40% of study subjects. The majority of patients (95.9%) received cancer directed surgery, 35.8% had radical or partial cystectomy, 15.8% of patients received radiation therapy combination with surgery. The median overall survival was 14 months (95% CI 7–21 months). 1-, 5-, and 10-year cancer specific survival rate were 53.9%, 28.4% and 25.8%. In a multivariate analysis, only tumor stage was found to be a significant prognostic factor for disease-specific survival. Conclusions. Urinary bladder carcinosarcoma commonly presented as high grade, advanced stage and aggressive behavior with a poor prognosis. Emphasis on early detection, including identification of risk factors is needed to improve the outcome for patients with this malignancy.

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“…At present, radical resection is the only curative treatment. Nephrectomy, radiation therapy and chemotherapy have been used alone or in combination (1,19). In the present case, due to the age of the patient and the history of previous pelvic surgery, a laparoscopic radical resection of the right kidney and ureter was performed.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of carcinosarcoma of the renal pelvis: A case report

et al. 2014

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Carcinosarcoma is a rare type of renal pelvis malignancy, the diagnosis of which requires the presence of malignant epithelial and mesenchymal components. The prognosis of this disease is extremely poor due to its rapid progression and widespread metastases. The present study describes a case of carcinosarcoma involving the right renal pelvis in a 73-year-old female who presented with intermittent hematuria and right-flank pain that had persisted for one month. Computed tomography revealed a 2.4×2.5 cm mass in the right renal pelvis, which was diagnosed as a right renal pelvic tumor. Laparoscopic radical resection of the right kidney and ureter was performed. Following surgery, immunohistochemical analysis showed positive reactions for epithelial and mesenchymal markers. Based on these findings, the patient was diagnosed with carcinosarcoma. Thus, immunohistochemical analysis is a critical method for the accurate diagnosis of carcinosarcoma.

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Carcinosarcoma of urothelial organs: Sequential involvement of urinary bladder, ureter, and renal pelvis

Cited by 28 publications

References 11 publications

Biphasic sarcomatoid carcinoma (carcinosarcoma) of the renal pelvis with heterologous chondrogenic differentiation

Biphasic sarcomatoid carcinoma (carcinosarcoma) of the renal pelvis with heterologous chondrogenic differentiation

Clinical Features of Sarcomatoid Carcinoma (Carcinosarcoma) of the Urinary Bladder: Analysis of 221 Cases

Diagnosis and treatment of carcinosarcoma of the renal pelvis: A case report

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