Biphasic sarcomatoid carcinoma (carcinosarcoma) of the renal pelvis with heterologous chondrogenic differentiation

Vermeulen, P; Hoekx, Lucien; Colpaert, Cécile; Wyndaele, Jean‐Jacques; Marck, Eric Van

doi:10.1007/s004280000190

Cited by 19 publications

(13 citation statements)

References 17 publications

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“…A similar case with a protracted course was published by others [13]. In the majority of cases, however, the prognosis is poor and patients seldom survive longer than 3 years [10,19,24].…”

Section: Discussionsupporting

confidence: 70%

“…A few cases were located in the renal pelvis or proximal ureter [14,17,24]. Tobacco smoking and irradiation of the genital tract in gynecological patients have been considered risk factors for the development of SC [19].…”

Section: Discussionmentioning

confidence: 99%

“…Most of these uncommon tumors are combinations of a transitional cell carcinoma and one or more different types of sarcoma, such as osteosarcoma, chondrosarcoma, or rhabdomyosarcoma. Apart from transitional cell carcinoma, other kinds of carcinoma have been described, including basaloid, squamous, and undifferentiated carcinoma [10,18,24].…”

Section: Introductionmentioning

confidence: 99%

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Molecular genetic findings in two cases of sarcomatoid carcinoma of the ureter: evidence for evolution from a common pluripotent progenitor cell?

et al. 2008

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The current World Health Organization classification recommends the usage of the term sarcomatoid carcinoma (SC) for all biphasic malignant neoplasms of the urinary tract exhibiting morphologic and/or immunohistochemical evidence of epithelial and mesenchymal differentiation. While most SC have been described in the urinary bladder, ureteral SC are extremely rare tumors. Here, we report on the clinical, morphological, and molecular biological findings of two cases in this unusual location. The genetic alterations investigated by comparative genomic hybridization in the epithelial and the mesenchymal component of both cases showed considerable but not complete overlap. Moreover, in spite of many morphological differences between the two cases, both cases shared some genetic gains and losses. Our findings are compatible with the concept that SC originates from a common pluripotent progenitor cell with a potential for epithelial and mesenchymal differentiation.

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“…A similar case with a protracted course was published by others [13]. In the majority of cases, however, the prognosis is poor and patients seldom survive longer than 3 years [10,19,24].…”

Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular genetic findings in two cases of sarcomatoid carcinoma of the ureter: evidence for evolution from a common pluripotent progenitor cell?

et al. 2008

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“…13,14 Immunohistochemical studies of the spindle cell component have demonstrated frequent expression of cytokeratin (CK), at least focally, as well as the expression of other epithelial markers, such as epithelial membrane antigen (EMA), but less consistently than CK. 15 Coexpression of vimentin is common, with muscle-specific actin infrequently expressed. 13,14 Immunohistochemical studies demonstrating biphasic differentiation (e.g., examinations of cytokeratin and vimentin expression revealed epithelial and mesenchymal differentiation, respectively) were also mandatory in the current diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Malignant priapism secondary to isolated penile metastasis from a renal pelvic carcinoma

Liu

Zeng

et al. 2014

CUAJ

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We report a case of isolated penile metastasis from renal pelvic carcinoma in a 69-year-old man with malignant priapism. The patient had radical resection of the renal pelvic carcinoma 2 months earlier with urothelial carcinoma (UC) and sarcomatoid differentiation histology. Physical examination showed no visible skin lesions, but a palpable hard nodule was present over the penile shaft. The imaging studies did not reveal other metastases. Cavernous-Glans shunt and nodule resection were performed, and histological examination showed metastasis UC with sarcomatoid differentiation. To our knowledge, we describe the first case of malignant priapism due to isolated penile metastasis of renal pelvic carcinoma. M alignant priapism is prolonged penile erection without sexual stimuli, and is generally related to medical treatment, sickle cell disease, leukemia, polycythemia, penile metastasis of malignancies, pelvic thrombophlebitis and neurological diseases. [1][2][3] Metastasis to the penis mimicking priapism is extremely rare, particularly in the absence of disseminated disease. About 300 cases have been reported. 4 Primary sites include the bladder (33%), prostate (30%), colon (17%) and kidney (7%). 5 Extra-pelvic sites, including the lung, pancreas, stomach, esophagus, melanoma and testis, have been noted. [6][7][8][9] Fewer than 20 cases of penile metastasis from renal cancer have been reported, most of them were renal cell carcinoma in origin. 10,11 On the other hand, penile metastasis has been a part of more widespread disease in about 90% of reported cases. 12 We describe a case of malignant priapism caused by penile metastasis of renal pelvic carcinoma in the absence of radiological disseminated disease. There have been no previous reports of renal pelvic carcinoma without regional metastasis with only penis metastasis. This is the first case of a renal pelvic carcinoma with isolated metastasis to penis. Case reportA 69-year-old male presented to our clinic with a 2-week history of malignant priapism. He had a radical resection of the renal pelvic carcinoma for right renal pelvic carcinoma at an outside centre 2 months previously ( Fig. 1) and the histopathology examination of the resected specimen revealed urothelial carcinoma (UC) and sarcomatoid differentiation (Fig. 2). All surgical margins and circum-renal lymph nodes removed during surgery were negative for tumour. The patient did not receive any kind of postoperative adjuvant therapy and was in a good general condition. On physical examination, the penis was tender, erect and consistency was wood-like, but the glans was flaccid. There was a palpable nodule in the corpora cavernosa of the penis, but no overlying skin necrosis of the glans. Corporal fine needle aspiration for blood-gas analysis failed to obtain any confirmatory sample. On digital rectal examination there was no suspicion of tumour involvement. Results of the laboratory evaluations were: white blood cell 9.52 × 109/L; red blood cell 3.78 × 1012/L; platelet 278 × 109/L; hemoglobin 1...

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“…In the "References," Chiu et al cited only nine papers regarding carcinosarcoma of the renal pelvis. [2][3][4][5][6][7][8][9][10] Other reports of carcinosarcoma of the renal pelvis have not been reviewed by Chiu et al [11][12][13][14] According to Kobayashi et al's review, 15 a total of 19 cases of carcinosarcoma or sarcomatoid carcinoma of the renal pelvis have been reported up until 1994. Eleven cases were reported as "true" carcinosarcoma and eight as sarcomatoid carcinoma.…”

mentioning

confidence: 99%

Carcinosarcoma of the Renal Pelvis: Inaccurate Documentation of Origin and Incomplete Review of the Literature

Pusiol¹,

Morichetti²,

Zorzi³

et al. 2011

Renal Failure

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Biphasic sarcomatoid carcinoma (carcinosarcoma) of the renal pelvis with heterologous chondrogenic differentiation

Cited by 19 publications

References 17 publications

Molecular genetic findings in two cases of sarcomatoid carcinoma of the ureter: evidence for evolution from a common pluripotent progenitor cell?

Molecular genetic findings in two cases of sarcomatoid carcinoma of the ureter: evidence for evolution from a common pluripotent progenitor cell?

Malignant priapism secondary to isolated penile metastasis from a renal pelvic carcinoma

Carcinosarcoma of the Renal Pelvis: Inaccurate Documentation of Origin and Incomplete Review of the Literature

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