Diagnosis and treatment of carcinosarcoma of the renal pelvis: A case report

Abstract

Carcinosarcoma is a rare type of renal pelvis malignancy, the diagnosis of which requires the presence of malignant epithelial and mesenchymal components. The prognosis of this disease is extremely poor due to its rapid progression and widespread metastases. The present study describes a case of carcinosarcoma involving the right renal pelvis in a 73-year-old female who presented with intermittent hematuria and right-flank pain that had persisted for one month. Computed tomography revealed a 2.4×2.5 cm mass in the right renal pelvis, which was diagnosed as a right renal pelvic tumor. Laparoscopic radical resection of the right kidney and ureter was performed. Following surgery, immunohistochemical analysis showed positive reactions for epithelial and mesenchymal markers. Based on these findings, the patient was diagnosed with carcinosarcoma. Thus, immunohistochemical analysis is a critical method for the accurate diagnosis of carcinosarcoma.

Carcinosarcoma Arising From the Renal Pelvis: A Rare Case Report

“…CSRP tends to be bulky, invasive, and fast-growing [12]. It is a high-grade tumor, has a poor prognosis, and has a low survival rate [1,8]. In a study published by Wang et al, most of the patients presented with a high histological grade and advanced-stage disease [10].…”

“…Wang et al reported the median cancer-specific survival time of CSRP as six months [10]. Dong et al reported the median cancer-specific survival time as one year [1]. The longest survival time in the literature was reported as two years by Chen et al [13].…”

“…At present, there is no optimal strategy for treatment because there have been too few clinical trials. Although radical nephrectomy, chemotherapy, and radiotherapy can be applied singly or in combination, recent information suggests that among these alternatives, only radical nephrectomy is curative [1]. Cancerspecific survival time is more significantly improved by radical nephrectomy than by chemotherapy or radiotherapy [1].…”

“…Although radical nephrectomy, chemotherapy, and radiotherapy can be applied singly or in combination, recent information suggests that among these alternatives, only radical nephrectomy is curative [1]. Cancerspecific survival time is more significantly improved by radical nephrectomy than by chemotherapy or radiotherapy [1]. Although radical resection surgery is often recommended, local recurrence, distant metastasis, or both are commonly observed in its aftermath [14].…”

“…Carcinosarcoma is a malignant tumor of a biphasic character comprising epithelial and mesenchymal components [1]. It is rarely seen and has an exceedingly aggressive nature [2].…”