Carcinoma of the perianal gland and associated structures in 1,2-dimethylhydrazine treated mice

Rowlatt, C; Defries, Elizabeth A.; Sheriff, Mohammed U.

doi:10.1016/0378-4274(81)90040-0

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…12 In 1981, Rowlatt described tumours of the perianal gland and squamous metaplasia of sebaceous gland in mice treated with 1,2-dimethylhydrazine. 13 In 1984, Poland and co-workers reported the histologic changes produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the skin of mice with the recessive mutation, hairless (hr/hr). They found, epidermal hyperplasia and hyperkeratosis, squamous metaplasia of the sebaceous gland and keratinized cyst formation, 14 and in 1997 Beckmen and co-workers described an unknown elephant syndrome called ''nothern elephant seal skin disease'' characterized by patchy to extensive alopecia epidermal ulceration and skin necrosis.…”

Section: Discussionmentioning

confidence: 99%

Squamous metaplasia of sebaceous gland

et al. 2000

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Squamous metaplasia in the skin has been reported in the eccrine ducts as eccrine squamous syringometaplasia (ESS). To our knowledge, squamous metaplasia of sebaceous gland (SMSG) has not been described in human skin. Twenty-two biopsy specimens from patients with pressure lesions after cardiac surgery with extracorporeal circulation were evaluated for the presence of SMSG. Squamous metaplasia of sebaceous gland was identified in five of the eight scalp biopsies and none of the buttock biopsies. The squamous metaplasia began in the germinative outer layer and advanced in a centripetal way. We believe that SMSG is an unspecific change of the sebaceous cells secondary to a chronic injury. Ischemia appears to play a mayor role, but other factors such as chronic trauma or toxicosis can not be ruled out.

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Section: Discussionmentioning

confidence: 99%