Detailed data from a colony of C57BL mice kept for research into ageing processes are given on weights of 13 organs between the ages of 6 and 30 months; pathological findings and x-ray results from animals aged 6, 24 and 30 months; age-specific tumour incidences in 24 organs in 3-month period up to 36 months of age. Results of previously published age-related studies of reproductive capacity, dental abnormalities and brain changes are summarised.
Sheriff, M. U. Spontaneous mammary carcinoma in C57BL and C3H Mice: A histochemical study. Acta path. microbiol. scand. Sect. A, 85: [311][312][313][314][315][316][317][318] 1977.The mucosubstances in a series of 12 mammary carcinomas arising in C57BL mice were compared with thaw in tumours in nine C3H mice and with normal "resting" and lactating glands. A strain diffemnce rather than a diffemnce according t o tumour type was found: The epithelid elements in the C57BL tumours contained mainly sialomucin with a little neutral mucosubstance and sulphomucin was present in same. Sulphated mucopolysaccharide was prominent in the stroma of these tumours The C3H mice tumurs contained no sulphomucin, less sialomucin but more neutral mucombstance. The mucosubstances were studied in serial transplants of four tumours. An acid to neutral mucombstance change with dedifferentiation of the tumour has been observed and found to be similar to a series of changes pmviously observed in a group of human gastrointestinal tumours.
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