Squamous metaplasia of sebaceous gland

Abstract

Squamous metaplasia in the skin has been reported in the eccrine ducts as eccrine squamous syringometaplasia (ESS). To our knowledge, squamous metaplasia of sebaceous gland (SMSG) has not been described in human skin. Twenty-two biopsy specimens from patients with pressure lesions after cardiac surgery with extracorporeal circulation were evaluated for the presence of SMSG. Squamous metaplasia of sebaceous gland was identified in five of the eight scalp biopsies and none of the buttock biopsies. The squamous metaplasia began in the germinative outer layer and advanced in a centripetal way. We believe that SMSG is an unspecific change of the sebaceous cells secondary to a chronic injury. Ischemia appears to play a mayor role, but other factors such as chronic trauma or toxicosis can not be ruled out.

Metaplasia: tissue injury adaptation and a precursor to the dysplasia–cancer sequence

“…It is rare for breast squamous metaplasia to progress to breast squamous cell carcinoma, although this cancer accounts for only <1% of all breast malignancies 16,17 . Skin squamous metaplasia can be observed in the setting of ulcers or scars and may be a precursor to squamous cell carcinoma 18,19 . Similarly, squamous metaplasia has been noted in sebaceous glands in the skin and other issues 19 .…”

“…Skin squamous metaplasia can be observed in the setting of ulcers or scars and may be a precursor to squamous cell carcinoma 18,19 . Similarly, squamous metaplasia has been noted in sebaceous glands in the skin and other issues 19 .…”

Metaplasia mimicking malignancy: A challenging case of florid eccrine squamous syringometaplasia

“…Similar changes can be observed in neutrophilic eccrine hidradenitis, leading some to consider ESSM along the spectrum of chemotherapeutic eccrine gland reactions 2,6 . Similar squamous metaplasia has also been described in sebaceous glands 9 …”