Carcinoma of the lip

Abstract

Carcinoma of the lip is a common variety of head and neck malignancy frequently seen in the elderly Caucasian male. Three hundred and fifty consecutive cases of invasive squamous cell carcinoma of the lip are anlayzed and the treatment methods and their results are presented. Surgical management is recommended for most patients because of the advantage of tumor margin assessment, avoidance of radiotherapy complications, and rapid rehabilitation.

Overexpression of cyclin D1 and interaction between p27Kip1 and tumour thickness predict lymph node metastases occurrence in lower lip squamous cell carcinoma

“…1,2 The prognosis for such patients depends mainly on the clinical staging of the neoplasia, especially with regard to its size and to lymph node status. [3][4][5] A multivariate analysis of over 1000 patients with lip carcinoma confirmed that the subgroup having the lowest determinate survival of 61% at five-year involved subjects with regional metastases to the cervical lymph nodes 6 ; these are observed at the time of initial lip carcinoma diagnosis in 2-12% of patients and another 3-13% will manifest nodal metastases sometime after the initial treatment for lip cancer.…”

“…[3][4][5] A multivariate analysis of over 1000 patients with lip carcinoma confirmed that the subgroup having the lowest determinate survival of 61% at five-year involved subjects with regional metastases to the cervical lymph nodes 6 ; these are observed at the time of initial lip carcinoma diagnosis in 2-12% of patients and another 3-13% will manifest nodal metastases sometime after the initial treatment for lip cancer. 2,6 For these reasons factors evidencing the potential aggressiveness of the tumour might be useful to identify which patients had a sufficient risk of occult lymph node metastases to justify elective regional treatment.…”

Erken Evre Dudak Kanserlerinde Boyuna Yaklaşım

“…5 However, surgery is the most acceptable modality for most patients because of the advantage of margin assessment, avoidance of radiotherapy complication, rapid rehabilitation and better cosmetic results. 6 There is almost consensus regarding treatment of primary lesion but it is not clear when neck dissection should…”

Our clinical approach to lip cancer; surgery and reconstruction principles

“…Kür oranı %83-96 arasında değişir (7,8) . Retrospektif klinik değerlendirmemizde, 5 yıllık sağkalım oranını %90 olarak hesapladık ve bunu literatürle uyumlu bulduk.…”