Carcinoma of supernumerary breast of vulva with bilateral mammary cancer

Abstract

Primary mammary cancer often develops at multiple sites in either one or both breasts, evidently the result of a common carcinogen acting in multicentric loci. The occurrence of carcinoma in accessory breast tissue has been recorded, including carcinoma in supernumerary breast tissue within the labium, although the latter is rare. A 62-year-old woman developed carcinoma of the right breast which was followed nearly five and one half years later by the occurrence of adenocarcinoma in supernumerary breast tissue within the left labium majus. Concomitantly, carcinoma was detected in the left breast. The three cancers, exhibited histologic features compatible with primary rather than metastatic lesions. The development of primary carcinoma in both breasts as well as within ectopic mammary tissue in the labium appears to be the first recorded instance of such an event. Cancer 38:2570-2574, 1976. HE WIDE FIELD ORIGIN OF BREAST CANCER T a n d the increased susceptibility of those who have had t h e disease t o develop additional lesions has been well documented. T h e pervasive multicentric effect of the carcinogens that cause breast cancer is strikingly illustrated i n this case presentation. The occurrence of bilateral m a m m a r y cancer in conjunction with carci-noma developing in ectopic mammary tissue within the vulva appears to be unique. CASE REPORT A white woman, age 62, was found by her family physician to have a palpable mass beneath the nipple of the right breast, during a routine physical examination. The mass was biopsied and found to be a ductal carcinoma and she underwent a right radical mastectomy. The tumor measured 5 cm in greatest diameter. Both intraductal and infiltrating scirrhous duct carcinoma were present with solid and glandular patterns some of the latter assuming a cribriform configuration (Fig. 1).

Pseudoangiomatous Stromal Hyperplasia in Lesions Involving Anogenital Mammary-Like Glands

“…[28][29][30] Most of those lesions are epithelial, representing either well-defined entities or corresponding to various changes resembling those seen in benign breast disease, as is, for example, sclerosing adenosis. 1,[3][4][5][6][7][8][9][10][13][14][15][16][17][19][20][21][22][23][24][25]27,30,31 We present three cases of lesions involving anogenital mammarylike glands demonstrating a stromal change identical to that known in mammary pathology as pseudoangiomatous stromal hyperplasia (PASH), a feature not previously recognized in this location, to our knowledge.…”

Occurrence of Supernumerary Nipples in Newborns

“…This is important because of the following reasons: (1) The supernu¬ merary breasts in females may re¬ spond to fluctuation in hormones in a physiologic manner, so that pubertal enlargement, premenstrual swelling, tenderness, and lactation during preg¬ nancy and parturition may occur.6 (2) They may be subject to the same dis¬ eases as normal breasts, including tu¬ mors, such as fibroadenoma,4 papillary adenoma,9 cysts,1 or carcinoma. 5 (3) They may be associated with other congenital diseases, such as vertebral anomalies,10 cardiac arrhythmias,11 or renal anomalies.12…”

Breast cancer with inguinal node recurrence

“…Other possible etiology could be the presence of ectopic breast tissue in the vulva with inguinal nodal involvement, a condition that has been described in under 15 cases till date [8,9]. Management essentially remains the same, apart from tailoring the surgery to radical vulvectomy and ilioinguinal nodal dissection and adjuvant RT.…”