Breast cancer with inguinal node recurrence

Abstract

Surgery and irradiation for breast cancer may interfere with conventional pathways of spread, leading to bizarre patterns of dissemination through lymphatics or through hematogenous route. Lymphoscintigraphic studies may help identify nodal involvement. Other possible reasons could be occurrence of primary breast cancer in accessory breast tissue retained in the vulva following involution of milk line. We describe a case of triple negative breast cancer, who developed contralateral breast cancer during treatment. Three years later, she developed isolated inguinal nodal metastases, which responded to local radiotherapy and chemotherapy. However, the patient relapsed after 2 years and could not be salvaged thereafter.

Inguinal lymph node metastasis in treated breast cancer: an extremely rare presentation and review of literature

“…Inguinal metastasis was present at the time of diagnosis of primary disease in four cases 10 12 13. In the rest, metastasis happened after 2 years11 and 6 years9 of treatment completion.…”

“…Metastasis to inguinal lymph nodes from breast cancer is extremely rare. So far, only six cases have been documented in the English scientific literature 9–13…”

Carcinoma Right Breast with Right Inguinal Lymph Nodes Metastasis, A Rare Case Report

“…Metastatic breast cancer can involves almost all organs of the body. Lymphatic route of spread involves regional lymph nodes while hematogenous route of spread involves in distant metastasis [5,6]. The regional spread can occur at the ipsilateral axillary, supraclavicular and sometimes at the ipsilateral internal mammary chain.…”

“…Non-regional lymph node involvement by breast cancer has been described earlier in mediastinum, para-aortic and pelvic lymph nodes. Metastasis of breast cancer to inguinal lymph nodes is extremely rare [5,9].…”

Non-Palpable Invasive Lobular Carcinoma Initially Diagnosed by Inguinal Lymph Node Biopsy

“…Breast cancer metastasis to the non-regional lymph nodes-mediastinal, retroperitoneal or pelvic-is uncommon. Till now, inguinal lymph node metastasis from breast cancer is rarely reported in English literature (8). Several pathways had been proposed to explain this unusual pattern of metastasis: through the skin and subcutaneous tissue, retrograde spread through submuscular fascia due to blockage of axillary lymphatics, altered lymphatic pathway, or presence of ectopic breast tissue in the vulva (9,10) To the best of our knowledge, eight cases of inguinal lymph node metastasis from breast cancer have been reported in English literature.…”