Carcinoma of Breast- A Study Profile

Lamture, Yashwant; Salunke, Balaji; Shahabuddin,

doi:10.14260/jemds/2018/1082

Cited by 9 publications

(4 citation statements)

References 9 publications

(9 reference statements)

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“…These included following lesions-UDH, ADH, and DCIS. Similar related studies were reported [14][15][16][17]. Studies reported by Yeola et al [18,19] Anand et al [20] were reviewed.…”

Section: Discussionsupporting

confidence: 66%

Establishment of Correlation of Ki-67 Proliferative Index Expression in the Peritumoral Tissue with Tumor Mass in ER (Estrogen Receptor) Positive Breast Carcinoma

Sukanya

Dawande

Bhake

et al. 2021

JPRI

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Background: Breast carcinoma is the second most frequently occurring malignant tumor. It usually arises in a multistep fashion from intermediary lesions to invasive cancer. Identifying such predominantly occurring lesions adjacent to malignancy and studying of Proliferative Ki-67 index and (ER) status in such lesions and substantiate their possible identity as a premalignant lesion. The study tries to establish the lesions which have the potential for progression to overt malignancy, thereby indicating early identification and appropriate treatment. Aim: To establish a correlation in the expression of Ki-67 proliferative index in the peritumoral tissue with tumor mass of ER-positive breast carcinomas. Objectives: 1.To study the expression of ER in breast tumor mass. 2. To study expression of Ki-67 proliferative index in breast tumor mass and peritumoral tissue. 3. To assess the expression of Ki-67 proliferative index in breast tumor mass and peritumoral tissue. Study design: Observational prospective study. Materials and Methods: 32 mastectomy specimens of diagnosed cases of breast carcinoma sent to the Histopathology Section are studied. Gross features are described and the histopathological section stained by (H & E) stain and immunohistochemistry using monoclonal antibody to (ER) and proliferation-associated antigen (Ki-67) are studied. Statistics: Chi-square test, Spearman’s rank-order correlation coefficient, and software used in the analysis were SPSS 22.0 version and Graph Pad Prism 6.0 version and p<0.05 is considered as the level of significance. Results: In this study out of 32 ER-positive cases, 24 showed positivity for Ki-67 in tumor mass and 22 cases showed high Ki-67 in peritumoral tissue. Maximum lesions were proliferative lesions with atypia like ADH and DCIS. Conclusion: Ki-67 is an accurate nuclear proliferative marker to assess cell proliferation status. In breast carcinoma adjacent peritumoral lesions show a high proliferative index which suggests a link and a trail of generation of premalignant lesions converting to invasive carcinoma. Proliferative lesions with and without atypia, moderate epithelioid, atypical ductal hyperplasia, and DCIS more or else equals IDC for Ki-67 proliferative index. Such cases should be regularly followed up for progression of these lesions to malignancy.

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“…These included following lesions-UDH, ADH, and DCIS. Similar related studies were reported [14][15][16][17]. Studies reported by Yeola et al [18,19] Anand et al [20] were reviewed.…”

Section: Discussionsupporting

confidence: 66%

Establishment of Correlation of Ki-67 Proliferative Index Expression in the Peritumoral Tissue with Tumor Mass in ER (Estrogen Receptor) Positive Breast Carcinoma

Sukanya

Dawande

Bhake

et al. 2021

JPRI

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“…Chemotherapy (dacarbazine, temozolomide, cisplatin and taxol) is mostly used for pre and postoperative adjuvant-therapy [16][17][18][19][20]. Studies related to carcinoma of breast and lungs have been reported [21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

A Brief Study on Primary Melanoma over Breast Region

Hiwale

Tyagi

2021

JPRI

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Background: Malignant melanoma is mostly found in mucous membranes and skin. So it’s occurrence on the breast skin is very rare. Case Presentation: In our study, 50-year-old female came to OPD with complaint of skin lesions on the breast since 2 months. On diagnosis, skin lesion was found to be malignant melanoma and the disease had metastasized in right axillary lymph node with discoloration over breast. Conclusion: The prognosis for patients with this disease is very poor. Important procedures which may increase the survival rate include, Early diagnosis and surgical resection with adjuvant therapy.

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“…Second, the existing studies are conflicting in their results. Some studies suggested that Sr. LDH was associated with poor prognosis in breast cancer, [7,8,9] whereas other studies have faild to demonstrate such correlations.…”

Section: Introductionmentioning

confidence: 99%

Study of Clinical Profile of Carcinoma Breast and Prognostic Significance of Serum Lactate Dehydrogenase as Tumor Marker in Carcinoma Breast

Malhotra

Wagh

Yeola

2021

JPRI

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Background: Breast cancer is the highly prevalent malignancy and is a major killer in women around world. In India, there is substantial statistically significant increase in breast cancer incidence patterns. Women from under developed areas(883000 cases) have a significantly higher no. of cases than those from developed areas (794,000) [1]. There are various risk factors associated with breast malignancy. A variety of bio-chemical markers have been tested to determine the malignancy, for the early detection of carcinoma of different origin. LDH is the easiest and cheapest to calculate of all of these indicators. Objectives: To study the clinical profile of patient with breast To study the prognostic significance of LDH as tumor marker in breast To compare post-operative LDH level in patient undergoing surgery for carcinoma breast v/s patient undergoing neoadjuvant chemotherapy. Compare variation in preoperative baselines LDH levels and post-operative LDH levels. Methodology: It is a prospective observational study done on patients with breast cancer. It will be conducted at Dept. of General Surgery , J.N.M.C and AVBRH, Sawangi (Meghe), Wardha. The study will be conducted on patients with Carcinoma Breast. Results: To be assessed after the study. Conclusion: Serum LDH is a good prognostic marker of breast cancer.

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Carcinoma of Breast- A Study Profile

Cited by 9 publications

References 9 publications

Establishment of Correlation of Ki-67 Proliferative Index Expression in the Peritumoral Tissue with Tumor Mass in ER (Estrogen Receptor) Positive Breast Carcinoma

Establishment of Correlation of Ki-67 Proliferative Index Expression in the Peritumoral Tissue with Tumor Mass in ER (Estrogen Receptor) Positive Breast Carcinoma

A Brief Study on Primary Melanoma over Breast Region

Study of Clinical Profile of Carcinoma Breast and Prognostic Significance of Serum Lactate Dehydrogenase as Tumor Marker in Carcinoma Breast

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