Carcinoidal lumor of the Kidney

Abstract

Two cases of primary renal carcinoidal tumor are reported. One was discovered in a 32-year-old pregnant woman. The other tumor was retrospectively diagnosed 3 years after nephrectomy in a 65-year-old woman who was hospitalized with a metastatic lesion in her lumbar spine. Both tumors are compared with 5 other cases previously reported in the literature, and hypotheses about the cause of renal localization of this tumor are reviewed.

Primary renal carcinoid tumors: clinicopathologic features of 9 cases with emphasis on novel immunohistochemical findings

“…If positive, this would have suggested possible nephrogenic differentiation in these tumors. The lack of reactivity, although not conclusive, supports the theory advanced by others that these are derived from extrarenal elements [9]. On a practical note, unlike reactivity with TTF-1 and CDX-2 from pulmonary and gastrointestinal carcinoid tumors, respectively, these markers could not be used to determine the site of origin of a metastatic carcinoid tumor.…”

“…Unlike carcinoid tumors arising in the gastrointestinal tract and lung, a definitive cell of origin within the renal parenchyma has not been identified [6][7][8]. Proposed theories for the origin of primary renal carcinoid tumors include derivation from neural crest cells entrapped within the metanephros during embryogenesis [9], neuroendocrine differentiation of a primitive totipotential cell [10,11], and hyperplasia of preexisting neuroendocrine cells within metaplastic or teratomatous epithelium [9,[11][12][13][14]. A review by Romero et al [2] demonstrated an association between renal carcinoid tumors and horseshoe kidneys, renal teratomas, and polycystic kidney disease in 18%, 14%, and 2% of reported cases, respectively [15].…”

Carcinoid Tumor of the Kidney Presenting as a Large Abdominal Mass: Report of a Case

“…6 The efficacy of interferon-α, -γ, or somatostatin analogue has been suggested in cases with liver metastasis of gastrointestinal carcinoid tumor. 10,[17][18][19] Systemic administrations of anticancer chemotherapeutic agents were often attempted to treat metastatic disease arising from carcinoid tumors. 20 The transarterial administration of these agents and/or embolization was reported to be a useful therapeutic strategy for liver metastasis of carcinoid tumors because they were often accompanied by an enhanced tumor vasculature.…”

Carcinoid of the kidney: radiologic findings

“…Only 10 cases have been reported in the literature [1][2][3][4][5][6][7]. This report describes a case with radiologic findings.…”

“…were not provided [4]. Ofthe remaining six cases, all were described as moderateto large-sized tumors ranging from 7 to 30 cm in greatest dimension [1 , 3-7].…”