Carcinoid Tumor of the Kidney Presenting as a Large Abdominal Mass: Report of a Case

Kawajiri, Hidemi; Onoda, Naoyoshi; Ohira, Masaichi; Nakatani, Tatsuya; Wakasa, Kenichi; Ishikawa, Tetsuro; Hirakawa, Kosei

doi:10.1007/s00595-003-2644-x

Cited by 29 publications

(25 citation statements)

References 19 publications

(10 reference statements)

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“…The pathologic findings that have been associated with metastasis are large tumor size, high mitotic rate (>1 per 10 HPF) and lack of confinement to the kidney. [1527] In our series, however, none of the carcinoids had any appreciable mitosis. One carcinoid tumor with hepatic metastasis was organ-confined (Stage T1b), and the other tumor with synchronous contralateral carcinoid tumors and lymph node metastases extended out of the kidney.…”

Section: Discussioncontrasting

confidence: 57%

“…Due to the rarity of these tumors, no standard treatment has been approved for locally advanced or metastatic disease. [27] In cases with liver metastases treatment is controversial, as nephrectomy rarely cures the disease but may help to relieve symptoms. Systemic and trans-arterial chemotherapy have been used in some patients with NETs with liver metastases.…”

Section: Discussionmentioning

confidence: 99%

“…Systemic and trans-arterial chemotherapy have been used in some patients with NETs with liver metastases. [27] Residual local disease can be treated with radiotherapy, and chemotherapy with platin-based agents can be used for treatment or palliation in the setting of metastatic disease. Although multimodality treatment appears to be warranted, outcome in the three patients with SCC or LCNEC in our series has been suboptimal despite this approach.…”

Section: Discussionmentioning

confidence: 99%

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Renal neuroendocrine tumors

2009

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Objectives:Neuroendocrine tumors (NETs) are uncommon tumors that exhibit a wide range of neuroendocrine differentiation and biological behavior. Primary NETs of the kidney, including carcinoid tumor, small cell carcinoma (SCC), and large cell neuroendocrine carcinoma (LCNEC) are exceedingly rare.Materials and Methods:The clinicopathologic features of renal NETs diagnosed at a single institution were reviewed along with all reported cases in the worldwide literature.Results:Eighty renal NETs have been described, including nine from our institution. Differentiation between renal NETs and the more common renal neoplasms (renal cell carcinoma, transitional cell carcinoma) can be difficult since clinical, radiographic, and histopathologic features overlap. Immunohistochemical staining for neuroendocrine markers, such as synaptophysin and chromogranin, can be particularly helpful in this regard. Renal carcinoids are typically slow-growing, may secrete hormones, and pursue a variable clinical course. In contrast, SCC and LCNEC often present with locally advanced or metastatic disease and carry a poor prognosis. Nephrectomy can be curative for clinically localized NETs, but multimodality treatment is indicated for advanced disease.Conclusions:A spectrum of NETs can rarely occur in the kidney. Renal carcinoids have a variable clinical course; SCC and LCNEC are associated with poor clinical outcomes. Diagnosis of NETs, especially LCNEC, requires awareness of their rare occurrence and prudent use of immunohistochemical neuroendocrine markers.

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Renal neuroendocrine tumors

2009

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“…From the diagnostic standpoint, renal carcinoid tumour and SCC have characteristic histological features and often can be suspected and diagnosed based on the H&E morphology. However, the occasional pseudo‐papillary appearance of carcinoid tumours might lead to misdiagnosis [13,19]. In the present study, one renal carcinoid was initially misdiagnosed as papillary tubular carcinoma and the diagnosis was changed to carcinoid tumour only after a metastatic carcinoid tumour was found in the liver.…”

Section: Discussionmentioning

confidence: 64%

Renal neuroendocrine tumours: a clinicopathological study

Lane¹,

Chery²,

Jour³

et al. 2007

BJU International

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“…No standard therapy focusing on renal carcinoid tumors has yet been proposed and surgical resection is currently the only treatment (17). Hormonotherapy may be a novel method aimed at patients with positive ER and PR expression.…”

Section: Discussionmentioning

confidence: 99%

Primary carcinoid tumor of the kidney with estrogen and progesterone receptor expression

Lin

Gao

et al. 2015

Oncology Letters

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Abstract. Primary carcinoid tumors are uncommon neoplasms in the kidney. The current study presents a case of primary carcinoid tumor of the kidney in a 49-year-old female who suffered from painless gross hematuria for half a month. Left hydronephrosis, a horseshoe kidney and a space-occupying lesion of the left ureter were found by abdominal computed tomography scans and ultrasonic testing. Surgery was performed and an oval tumor was found under the left ureter; the tumor and left kidney were excised completely. The neoplasm was composed of solid nests of cells, trabeculae, adenoid structures and anastomosing cords in a loose and myxoid background. The tumor cells, which were consistent in volume, exhibited centrally oval nuclei with inconspicuous nucleoli, and eosinophilic finely granular cytoplasm. Upon immunohistochemical staining, the neoplastic cells were positive for AE1/AE3, vimentin, synaptophysin, chromogranin A, estrogen receptor and progesterone receptor, while being negative for epithelial membrane antigen, inhibin A, cluster of differentiation (CD)99, S-100 and CD10. Based on the histological characteristics, a diagnosis of primary carcinoid tumor of the left kidney was formed. The patient did not receive further treatment. The total follow-up period was 18 months after the surgery and repeated imaging examinations every 6 months revealed no recurrence.

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Carcinoid Tumor of the Kidney Presenting as a Large Abdominal Mass: Report of a Case

Cited by 29 publications

References 19 publications

Renal neuroendocrine tumors

Renal neuroendocrine tumors

Renal neuroendocrine tumours: a clinicopathological study

Primary carcinoid tumor of the kidney with estrogen and progesterone receptor expression

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