Carcinogenicity and mechanism of action of fumonisin B1: a mycotoxin produced by Fusarium moniliforme (=F. verticillioides)

Voss, Kenneth A.; Howard, Paul C.; Riley, Ronald T.; Sharma, Raghubir P.; Bucci, Thomas J.; Lorentzen, Ronald J.

doi:10.1016/s0361-090x(02)00011-9

Cited by 89 publications

(41 citation statements)

References 40 publications

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“…fumonisin mycotoxins were found to be carcinogenic in rats due to their action in inhibiting ceramide synthase in vitro which in turn would enhance the production of tumor necrosis factor α (TNfα). This leads to the initiation of cells apoptosis (143). In addition, an experiment was conducted using 28 mycotoxins to investigate their action against hepatocytes of rats and mice.…”

Section: Mycotoxins and Their Carcinogenicitymentioning

confidence: 99%

“…It was proven that fumonisin B1 are involved in the development of renal carcinomas in male rats, and liver cancer in female mice which could occur in humans as well (189). Finally, Fumonisin B1 was found to cause inhibition in the production of ceramide synthase in vitro which in turn enhances tumor necrosis factor α, production and cause apoptosis (143). finally, fumonisins mycotoxins were found to contribute to the development of neural tube defects among Mexican-American woman in south Texas, and was characterized by defects in the brain, spine, or spinal cord of fetus in the first month of pregnancy (190).…”

Section: Mycotoxins and Their Carcinogenicitymentioning

confidence: 99%

“…finally, fumonisin B1 was found to cause inhibition in the production of ceramide synthase which will lead to enhancing tumor necrosis factor α, production leading to apoptosis (143) and the ability of this mycotoxin to induce apoptosis can be used to detect the involvement of this mycotoxin in causing skin cancer.…”

Section: Mycotoxin Research Gaps and The Recommended New Research Areasmentioning

confidence: 99%

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Effects of different mycotoxins on humans, cell genome and their involvement in cancer

et al. 2017

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Abstract. The chemical nature of most of the mycotoxins makes them highly liposoluble compounds that can be absorbed from the site of exposure such as from the gastrointestinal and respiratory tract to the blood stream where it can be dissimilated throughout the body and reach different organs such as the liver and kidneys. Mycotoxins have a strong tendency and ability to penetrate the human and animal cells and reach the cellular genome where it causes a major mutagenic change in the nucleotide sequence which leads to strong and permanent defects in the genome. This defect will eventually be transcribed, translated and lead to the development of cancer. In this review, the chemical and physical nature of mycotoxins, the action of mycotoxins on the cellular genome and its effect on humans, mycotoxins and their carcinogenicity and mycotoxins research gaps are discussed, and new research areas are suggested. The research review posed various questions. What are the different mycotoxins that can cause cancer, what is the role of mycotoxins in causing cancer and what types of cancers can be caused by mycotoxins? These questions have been selected due to the significant increase in the mycotoxin contamination and the cancer incidence rate in the contemporary world. By revealing and understanding the role of mycotoxins in developing cancer, measures to reduce the risks and incidents of cancer could be taken.

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Section: Mycotoxins and Their Carcinogenicitymentioning

confidence: 99%

Section: Mycotoxins and Their Carcinogenicitymentioning

confidence: 99%

Section: Mycotoxin Research Gaps and The Recommended New Research Areasmentioning

confidence: 99%

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Effects of different mycotoxins on humans, cell genome and their involvement in cancer

et al. 2017

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“…The levels of free Sa and sphingosine (So) in tissues and biological fluids may be compared by constructing a ratio of Sa to So (Sa/So ratio) that is used as an early biomarker of exposure to the mycotoxin (13). The inhibition of ceramide synthase is also likely to disrupt overall sphingolipid metabolism and, theoretically, sphingolipidmediated regulation of important cell events such as apoptosis and mitosis, which are probably in part responsible for the cytotoxic and carcinogenic properties of the mycotoxin (11,14).…”

Section: Introductionmentioning

confidence: 99%

Glucose Reaction with Fumonisin B₁Partially Reduces Its Toxicity in Swine

Fernandez-Surumay

Osweiler

Yaeger

et al. 2004

J. Agric. Food Chem.

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Acute and subacute intraperitoneal doses of fumonisin B1 (FB1) were administered to test the efficacy of the FB1-glucose reaction products in detoxifying FB1 in swine. In the acute study at 11 µmol of FB1/kg of body weight, five of six pigs administered FB1 and four of six pigs administered FB1-glucose died from acute pulmonary edema. Analysis of weight gain, serum aspartate aminotransferase and γ-glutamyltransferase, total cholesterol, and pathological evaluation did not provide evidence of protection against FB1 toxicity by the FB1-glucose reaction products. In the subacute study at 5.5 µmol of FB1/kg of body weight, one pig administered FB1 died from liver damage. Analysis of serum aspartate aminotransferase, γ-glutamyltransferase, and total bilirubin showed protection against FB1 toxicity by the FB1-glucose reaction products. The levels of sphinganine and sphinganine/sphingosine ratios in serum and liver as well as pathologic findings provided definitive evidence of protection against the FB1 toxic effects by this detoxification procedure (p < 0.05). Acute and subacute intraperitoneal doses of fumonisin B 1 (FB 1 ) were administered to test the efficacy of the FB 1 -glucose reaction products in detoxifying FB 1 in swine. In the acute study at 11 µmol of FB 1 /kg of body weight, five of six pigs administered FB 1 and four of six pigs administered FB 1 -glucose died from acute pulmonary edema. Analysis of weight gain, serum aspartate aminotransferase and γ-glutamyltransferase, total cholesterol, and pathological evaluation did not provide evidence of protection against FB 1 toxicity by the FB 1 -glucose reaction products. In the subacute study at 5.5 µmol of FB 1 /kg of body weight, one pig administered FB 1 died from liver damage. Analysis of serum aspartate aminotransferase, γ-glutamyltransferase, and total bilirubin showed protection against FB 1 toxicity by the FB 1 -glucose reaction products. The levels of sphinganine and sphinganine/sphingosine ratios in serum and liver as well as pathologic findings provided definitive evidence of protection against the FB 1 toxic effects by this detoxification procedure (p < 0.05).

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“…The toxicity of AFM1 is about one order of magnitude less than that of AFB1 (Creppy, 2002;Van Egmond & Jonker, 2004 ;Voss et al, 2002).…”

Section: Aflatoxinsmentioning

confidence: 99%

Carcinogen Role of Food by Mycotoxins and Knowledge Gap

Ferrante¹,

Sciacca²,

Conti³

2012

Carcinogen

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Carcinogenicity and mechanism of action of fumonisin B1: a mycotoxin produced by Fusarium moniliforme (=F. verticillioides)

Cited by 89 publications

References 40 publications

Effects of different mycotoxins on humans, cell genome and their involvement in cancer

Effects of different mycotoxins on humans, cell genome and their involvement in cancer

Glucose Reaction with Fumonisin B₁Partially Reduces Its Toxicity in Swine

Carcinogen Role of Food by Mycotoxins and Knowledge Gap

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Carcinogenicity and mechanism of action of fumonisin B1: a mycotoxin produced by Fusarium moniliforme (=F. verticillioides)

Cited by 89 publications

References 40 publications

Effects of different mycotoxins on humans, cell genome and their involvement in cancer

Effects of different mycotoxins on humans, cell genome and their involvement in cancer

Glucose Reaction with Fumonisin B1Partially Reduces Its Toxicity in Swine

Carcinogen Role of Food by Mycotoxins and Knowledge Gap

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Glucose Reaction with Fumonisin B₁Partially Reduces Its Toxicity in Swine