Carboxymethyl starch encapsulated 5-FU and DOX co-loaded layered double hydroxide for evaluation of its in vitro performance as a drug delivery agent

Ranjbar, Elaheh; Namazi, Hassan; Pooresmaeil, Malihe

doi:10.1016/j.ijbiomac.2021.12.181

Cited by 28 publications

(13 citation statements)

References 60 publications

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“…Additionally, CMS@LDH-MTX microspheres showed acceptable enzymatic breakdown and cancerous cell-killing ability, becoming a versatile therapeutic choice for the delivery of anticancer drugs to the intestinal area. Similarly, in another study, CMS was also used as a coating of simultaneously co-loaded 5-FU and DOX into MgAl-LDH to improve colon cancer therapy [ 241 ]. The results showed that coating the LDH-drug hybrids with CMS as a pH-sensitive biopolymer improved performance in cancer treatment exhibiting a controlled release profile in acidic conditions (about 22% and 29% of DOX and 5-Fu, respectively), allowing most of the loaded drug to be released into the intestinal environment.…”

Section: Drug Delivery Systems Based On Organic Polymers and Layered ...mentioning

confidence: 99%

Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering

et al. 2023

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The development of biomaterials has a substantial role in pharmaceutical and medical strategies for the enhancement of life quality. This review work focused on versatile biomaterials based on nanocomposites comprising organic polymers and a class of layered inorganic nanoparticles, aiming for drug delivery (oral, transdermal, and ocular delivery) and tissue engineering (skin and bone therapies). Layered double hydroxides (LDHs) are 2D nanomaterials that can intercalate anionic bioactive species between the layers. The layers can hold metal cations that confer intrinsic biological activity to LDHs as well as biocompatibility. The intercalation of bioactive species between the layers allows the formation of drug delivery systems with elevated loading capacity and modified release profiles promoted by ion exchange and/or solubilization. The capacity of tissue integration, antigenicity, and stimulation of collagen formation, among other beneficial characteristics of LDH, have been observed by in vivo assays. The association between the properties of biocompatible polymers and LDH-drug nanohybrids produces multifunctional nanocomposites compatible with living matter. Such nanocomposites are stimuli-responsive, show appropriate mechanical properties, and can be prepared by creative methods that allow a fine-tuning of drug release. They are processed in the end form of films, beads, gels, monoliths etc., to reach orientated therapeutic applications. Several studies attest to the higher performance of polymer/LDH-drug nanocomposite compared to the LDH-drug hybrid or the free drug.

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Section: Drug Delivery Systems Based On Organic Polymers and Layered ...mentioning

confidence: 99%

Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering

et al. 2023

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“…Several recent studies have analyzed and enhanced the LDH-based delivery of therapeutic molecules [ 5 , 53 ], anti-inflammatory drugs [ 54 , 55 ], anticancer drugs [ 27 , 56 , 57 , 58 , 59 , 60 ], and peptide hormones [ 61 ] by improving the drug-release property of LDHs by modification via intercalation, absorption, and other methods. For example, a publication reported the intercalation of nicotinic acid (NA) in LDH interlayers [ 5 ].…”

Section: Design Of Functional Ldh Nanohybrids For Drug Deliverymentioning

confidence: 99%

Multifunctional Layered Double Hydroxides for Drug Delivery and Imaging

Choi

2023

Nanomaterials

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Two-dimensional nanomaterials, particularly layered double hydroxides (LDHs), have been widely applied in the biomedical field owing to their biocompatibility, biodegradability, controllable drug release/loading ability, and enhanced cellular permeability. Since the first study analyzing intercalative LDHs in 1999, numerous studies have investigated their biomedical applications, including drug delivery and imaging; recent research has focused on the design and development of multifunctional LDHs. This review summarizes the synthetic strategies and in-vivo and in-vitro therapeutic actions and targeting properties of single-function LDH-based nanohybrids and recently reported (from 2019 to 2023) multifunctional systems developed for drug delivery and/or bio-imaging.

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“…et al, 2022 ), alginate ( Hassani et al, 2022 ; Zhang H.-Y. et al, 2022 ), and starch ( Ranjbar et al, 2022 ), possess excellent biocompatibility, biodegradability, and low toxicity. Among the synthetic polymers, poly(lactic-co-glycolic acid) (PLGA) ( Shi et al, 2022 ), poly( l -lactic acid) (PLLA) ( Xu Y. et al, 2020 ), and poly(ester amide) (PEA) ( Tellegen et al, 2018 ) have good degradability, modifiability, and mechanical stability.…”

Section: Application Of Microsphere-based Delivery Systems In Ivddmentioning

confidence: 99%

New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System

Guo

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Intervertebral disc (IVD) degeneration (IVDD) has been considered the dominant factor in low back pain (LBP), and its etiological mechanisms are complex and not yet fully elucidated. To date, the treatment of IVDD has mainly focused on relieving clinical symptoms and cannot fundamentally solve the problem. Recently, a novel microsphere-based therapeutic strategy has held promise for IVD regeneration and has yielded encouraging results with in vitro experiments and animal models. With excellent injectability, biocompatibility, and biodegradability, this microsphere carrier allows for targeted delivery and controlled release of drugs, gene regulatory sequences, and other bioactive substances and supports cell implantation and directed differentiation, aiming to improve the disease state of IVD at the source. This review discusses the possible mechanisms of IVDD and the limitations of current therapies, focusing on the application of microsphere delivery systems in IVDD, including targeted delivery of active substances and drugs, cellular therapy, and gene therapy, and attempts to provide a new understanding for the treatment of IVDD.

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Carboxymethyl starch encapsulated 5-FU and DOX co-loaded layered double hydroxide for evaluation of its in vitro performance as a drug delivery agent

Cited by 28 publications

References 60 publications

Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering

Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering

Multifunctional Layered Double Hydroxides for Drug Delivery and Imaging

New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System

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