New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System

Guo, Taowen; Zhang, Xiaobo; Hu, Yi-Cun; Lin, Mo‐Jun; Zhang, Ruihao; Chen, Xiangyi; Yu, De-Chen; Yao, Xin; Wang, Peng; Zhou, Hai-Yu

doi:10.3389/fbioe.2022.933901

Cited by 16 publications

(18 citation statements)

References 156 publications

(215 reference statements)

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“…200,201 Different manufacturing processes can produce microspheres with different structural characteristics to allow microspheres to be used in different medical applications. 202 Materials for the preparation of microspheres include glass (such as that made of silicate, borate, or phosphate), ceramics, and polymers. Polymer-based porous microspheres have been extensively investigated for drug release and as delivery vehicles for other biological components.…”

Section: Microspheresmentioning

confidence: 99%

“…Commonly used methods for microsphere preparation include evaporation of emulsification solvent, phase separation, spray drying, electro‐spraying, and microfluidic methods 200,201 . Different manufacturing processes can produce microspheres with different structural characteristics to allow microspheres to be used in different medical applications 202 …”

Section: Further Delivery Strategiesmentioning

confidence: 99%

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Biomaterial‐based gene therapy

Gao

et al. 2023

MedComm

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Gene therapy, a medical approach that involves the correction or replacement of defective and abnormal genes, plays an essential role in the treatment of complex and refractory diseases, such as hereditary diseases, cancer, and rheumatic immune diseases. Nucleic acids alone do not easily enter the target cells due to their easy degradation in vivo and the structure of the target cell membranes. The introduction of genes into biological cells is often dependent on gene delivery vectors, such as adenoviral vectors, which are commonly used in gene therapy. However, traditional viral vectors have strong immunogenicity while also presenting a potential infection risk. Recently, biomaterials have attracted attention for use as efficient gene delivery vehicles, because they can avoid the drawbacks associated with viral vectors. Biomaterials can improve the biological stability of nucleic acids and the efficiency of intracellular gene delivery. This review is focused on biomaterial‐based delivery systems in gene therapy and disease treatment. Herein, we review the recent developments and modalities of gene therapy. Additionally, we discuss nucleic acid delivery strategies, with a focus on biomaterial‐based gene delivery systems. Furthermore, the current applications of biomaterial‐based gene therapy are summarized.

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Section: Microspheresmentioning

confidence: 99%

Section: Further Delivery Strategiesmentioning

confidence: 99%

Biomaterial‐based gene therapy

Gao

et al. 2023

MedComm

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“…Polymers, including artificial polymers and natural polymers, are used to prepare microspheres due to their biocompatibility and easy modification [39]. At present, several methods, including emulsification and electrohydrodynamic spraying technology, have been developed to prepare microspheres.…”

Section: Polymers For Microspheresmentioning

confidence: 99%

Progress in microsphere-based scaffolds in bone/cartilage tissue engineering

Pan,

Su,

Yao

2023

Biomed. Mater.

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Bone/cartilage repair and regeneration have been popular and difficult issues in medical research. Tissue engineering is rapidly evolving to provide new solutions to this problem, and the key point is to design the appropriate scaffold biomaterial. In recent years, microsphere-based scaffolds have been considered suitable scaffold materials for bone/cartilage injury repair because microporous structures can form more internal space for better cell proliferation and other cellular activities, and these composite scaffolds can provide physical/chemical signals for neotissue formation with higher efficiency. This paper reviews the research progress of microsphere-based scaffolds in bone/chondral tissue engineering, briefly introduces types of microspheres made from polymer, inorganic and composite materials, discusses the preparation methods of microspheres and the exploration of suitable microsphere pore size in bone and cartilage tissue engineering, and finally details the application of microsphere-based scaffolds in biomimetic scaffolds, cell proliferation and drug delivery systems.

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“…encapsulation rate and excellent slow-release properties conferred by the porous structure, coupled with good surface adhesion for cell immigration, have led to the gradual emergence of microspheres as the carrier of choice in the field of tissue engineering (Guo et al, 2022). In order to achieve long-term delivery and avoid leakageassociated complications, stimulus-responsive composite hydrogels have been employed.…”

mentioning

confidence: 99%

“…The microsphere is a class of three-dimensional spherical structures with an average particle size of 1–1000 μm that could be used in cell carrying and biomedical substance delivery. Guo et al recently reviewed the use of various microspheres for disc regeneration and clearly demonstrated that the high encapsulation rate and excellent slow-release properties conferred by the porous structure, coupled with good surface adhesion for cell immigration, have led to the gradual emergence of microspheres as the carrier of choice in the field of tissue engineering ( Guo et al, 2022 ). In order to achieve long-term delivery and avoid leakage-associated complications, stimulus-responsive composite hydrogels have been employed.…”

mentioning

confidence: 99%

Editorial: Biomaterial advances in intervertebral disc degeneration

Huang

Feng

2023

Front. Bioeng. Biotechnol.

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Editorial on the Research Topic Biomaterial advances in intervertebral disc degenerationNeck and back pain are ubiquitous in modern society, leading to serious lifelong disability and placing an enormous socioeconomic burden on the global healthcare system. Although the etiology of neck and back pain is multifaceted and still incompletely understood, intervertebral disc degeneration (IDD) is considered to be the most significant contributor. The current treatments for IDD, including medication, surgery, and others, are limited to symptomatic relief but fail to restore the structure and homeostasis of the intervertebral disc. The failure leads to the steady deterioration of compromised discs and undesirable consequences, such as recrudescence or adjacent vertebral disease. Tissueengineered approaches hold great promise for the treatment of IDD. Gullbrand et al. designed and manufactured a disc-like angle ply structure (DAPS), which has distinct components that mimic the structure of the native disc. The long-term integration and mechanical function of engineered DAPS in vivo, even in large animal models have been successfully tested (Gullbrand et al., 2018). After that, Sloan et al. demonstrated that combined nucleus pulposus augmentation using hyaluronic acid injection and annulus fibrosus repair using photo cross-linked collagen patch restore nucleus pulposus hydration, heal annulus fibrosus defects and maintain native torsional and compressive stiffness up to 6 weeks after discectomy injury in a large animal model. These studies move this approach a step towards translational feasibility (Sloan et al., 2020).Given the indispensable role of biomaterials in tissue engineering for IDD, we prepared this Research Topic to summarize the progress in this field. The harsh microenvironment of IDD is not suitable for disc regeneration. Therefore, various therapeutic agents, including small molecular, growth factor, exosome, and nucleic acids-based drugs are employed to reduce the inflammatory response, promote extracellular matrix synthesis, and direct cell differentiation to create a good regenerative microenvironment. Traditional drug delivery such as systemic administration or via in situ injection has low drug availability and high offtarget toxicity. Liu et al. have systematically demonstrated that biomaterials-based nanodrug delivery systems have improved treatment results of therapeutic agents for IDD because of their good biodegradability, biocompatibility, precise targeted specific drug delivery, prolonged drug release time, and enhanced drug efficacy (Liu et al., 2023). Except for drug delivery, a good cell carrier is critical for tissue regeneration. The microsphere is a class of three-dimensional spherical structures with an average particle size of 1-1000 μm that could be used in cell carrying and biomedical substance delivery. Guo et al. recently reviewed the use of various microspheres for disc regeneration and clearly demonstrated that the high

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New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System

Cited by 16 publications

References 156 publications

Biomaterial‐based gene therapy

Biomaterial‐based gene therapy

Progress in microsphere-based scaffolds in bone/cartilage tissue engineering

Editorial: Biomaterial advances in intervertebral disc degeneration

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