Multifunctional Layered Double Hydroxides for Drug Delivery and Imaging

Abstract

Two-dimensional nanomaterials, particularly layered double hydroxides (LDHs), have been widely applied in the biomedical field owing to their biocompatibility, biodegradability, controllable drug release/loading ability, and enhanced cellular permeability. Since the first study analyzing intercalative LDHs in 1999, numerous studies have investigated their biomedical applications, including drug delivery and imaging; recent research has focused on the design and development of multifunctional LDHs. This review summarizes the synthetic strategies and in-vivo and in-vitro therapeutic actions and targeting properties of single-function LDH-based nanohybrids and recently reported (from 2019 to 2023) multifunctional systems developed for drug delivery and/or bio-imaging.

Confined Space Nanoarchitectonics for Dynamic Functions and Molecular Machines

“…Functional materials must be created to meet these needs. These include generating energy [1][2][3][4][5][6][7], storing energy [8][9][10][11][12][13], detecting and removing environmental hazards [14][15][16][17][18][19], carbon neutrality [20][21][22][23], purifying water [24][25][26][27][28], detecting and handling viruses [29][30][31][32][33], delivering drugs [34][35][36][37][38], treating illness and injury [39][40][41][42][43][44], developing devices for these functions [45][46][47][48][49], and information conversion…”

In Situ Growth of Mg-Fe Layered Double Hydroxides (LDH) Film on Titanium Dental Implant Substrates for pH Regulation in Oral Environments

“…All these experimental findings and investigations suggest that LDHs are promising materials for the coating and surface biofunctionalization of Ti-based implants. In fact, LDH coatings could be used as a protective shield for these systems, even enhancing the cell adhesion and the osseointegration capacity [15,16]. However, in most related studies, the LDHs films that are investigated as biomaterials generally contain harmful elements to human body, such as Al, which is related to skeletal, neurological, and hematological risks.…”

Incorporation of Photo- and Thermoresponsive N-Salicylidene Aniline Derivatives into Cobalt and Zinc Layered Hydroxides

“…Layered compounds represent prototypical models for such hybridization. − Indeed, such materials are ideal candidates to facilitate hybridization by hosting a variety of organic compounds in their interlayer space via versatile chemical routes. Among layered materials, layered double hydroxides (LDHs) with functional organic compounds have been extensively explored for catalysis, , flame retardancy, photovoltaics, , CO 2 capture, drug delivery, , electrode materials, , combining photochromism and magnetism, , etc . However, despite being relatively easy to synthesize, hybrid LDHs present weak bonds between the organic intercalants and the inorganic host, which somehow limits the possibility of synergy between the properties of the two subnetworks via through-space interactions.…”