Carboxymethyl Chitosan/Tannic Acid Hydrogel with Antibacterial, Hemostasis, and Antioxidant Properties Promoting Skin Wound Repair

Abstract

Local causes of slow wound healing include infection and wound hemorrhage. Using sodium bicarbonate as a neutralizer, a variety of carboxymethyl chitosan−tannic acid (CMC-TA) composite hydrogels solidify through hydrogen bonding in this study. The best-performing hydrogel was synthesized by altering the concentration of TA and exhibited remarkable mechanical properties and biocompatibility. Following in vitro characterization tests, the CMC-TA hydrogel exhibited remarkable antibacterial and antioxidant properties, as well as quick hemostasis capabilities. In the in vivo wound healing study, the results showed that the CMC-TA hydrogel could relieve inflammation and promote the recovery of skin incision, reepithelialization, and collagen deposition. Overall, this multifunctional hydrogel could be an ideal wound dressing for the clinical therapy of full-thickness wounds.

Engineering ultrasound-activated piezoelectric hydrogels with antibacterial activity to promote wound healing

“…28 Moreover, due to the limited hemostatic and antibacterial properties of CMCS, TA was introduced to cross-link with CMCS by hydrogen bond. 21 At the same time, CBM molecules can not only form hydrogen bonds with hydroxyl groups as carboxyl donors but also link with CMCS in the form of hydrogen bonds. 16 To form the hydrogel with a three-dimensional network structure (Fig.…”

“…It can also stimulate angiogenesis and collagen precipitation. 21 Hydrogels formed by TA and CMCS are a potential option for the advancement of full-thickness wound healing.…”

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

“…The hydrogel exhibits antibiofilm activity against Methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis, and it reduces the viability of the formed biofilms. Due to hemostatic property, tissue adhesion, wound healing, and infection prevention, the chitosan hydrogel possesses great promise as a tissue adhesive for sutureless wound closure in surgical procedures [ 32 , 33 , 154 , 155 , 156 , 196 ].…”

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

“…Tannic acid (TA) was also incorporated in carboxymethyl chitosan (CMCS) to enhance its antibacterial and hemostatic qualities as reported by Zhou et al 150 The hydrogen bond between CMCS and TA contributed to the burst initial release of TA, which is beneficial in the initial phase of wound healing. In addition, TA will enhance the hemostatic properties of CMCS by reacting with blood protein and stopping the bleeding process.…”