Carbon‐Quantum‐Dots‐Loaded Mesoporous Silica Nanocarriers with pH‐Switchable Zwitterionic Surface and Enzyme‐Responsive Pore‐Cap for Targeted Imaging and Drug Delivery to Tumor

Liu, Zhongning; Chen, Xin; Zhang, Xiaojin; Gooding, J. Justin; Zhou, Yongsheng

doi:10.1002/adhm.201600002

Cited by 69 publications

(48 citation statements)

References 32 publications

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“…12 Loading CQDs with enzyme-responsive mesoporous silica nanocarriers with a pH-switchable zwitterionic surface can be used for targeted imaging and drug delivery to tumors. 45 …”

Section: Biomedical Applications Bioimagingmentioning

confidence: 99%

“…Under physiologic and HixsonCrowell standard conditions, haloperidol (anti-psychotic) grafted CQDs with cysteamine hydrochloride can be used for controlled release for up to 40 h. In addition to bioimaging, conjugation of ciprofloxacin (a broad spectrum antibiotic) with CQDs under physiologic conditions also gave an efficient new nanocarrier for controlled drug release. 12,44,45 Nanomedicine CQDs, being small fluorescent NPs, serve as a better alternative to other fluorescent nanomaterials. CQDs have an appreciable application in nanomedicine because they do not cause any kind of toxicity in animals.…”

Section: Targeted Drug Deliverymentioning

confidence: 99%

“…However, it is not clear whether CQDs can specifically target a disease state, thus limiting their efficacy in therapeutic applications. 12,44,45 Biosensing CQDs have a wide application in biosensing. Certain properties of CQDs, such as high water solubility, surface modification flexibility, better cell permeation, low toxicity, and high biocompatibility make them potential biosensors.…”

Section: Targeted Drug Deliverymentioning

confidence: 99%

“…This particular immunosensor was used as a fine example for the immunoassay development to identify analytes with preferable antigens and antibodies. 12,44,45 Vitamin B 12 -coated CQD serve as a radiometric nanosensor that exhibit an excellent selectivity for phenolic carbofuran. 46 In addition to this, CQDs are used as a fluorescent probe for recognizing small bioanalytes (anti-bacterial drugs).…”

Section: Targeted Drug Deliverymentioning

confidence: 99%

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Carbon Quantum Dots: Synthesis, Characterization and Biomedical Applications

Singh

Arora

Dhiman

et al. 2018

tjps

113

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ÖZ INTRODUCTIONLuminescent semiconductor nano crystals of size 1-10 nanometers with rich surface chemistry and unique optical properties are called quantum dots (QDs). Different compounds belonging to group 2 to 4 and 3 to 5, e.g., Ag, Cd, Zn, Hg, Se, Ln, Pb, P, and Te lead to the formation of QDs. These have become an obligatory tool for traceable targeted delivery, biomedical research, and different therapy applications. Longterm fluorescence imaging and the detection of the properties of these nanoparticles (NPs) have made them imperative in biomedical research. Different properties of QDs such as resistance to photobleaching, superior signal brightness, larger absorption coefficients, light emission, and contemporaneous excitation of different fluorescence colors make them unique, as well as indispensable. Advances in quantum surface chemistry studies have led to the development of polymer-encapsulated probes with high fluorescence properties that are stable under complex biologic conditions. To use QDs in biologic studies, it is extremely important to cap or passivate the ZnS or CdS layer around the QD (CdSe). This layering of ZnS or CdS leads to the improvement of the fluorescence quantum yield (QY) of QDs and provides protection against photo-oxidation. QDs have had a major impact in molecular diagnostics and in tissue molecular KKN, ayırt edici özellik olarak, 10 nm'den daha küçük boyutu olan, küçük karbon nanopartiküllerdir ve izlenebilir hedeflenmiş salım, biyomedikal araştırma ve farklı terapi uygulamaları için zorunlu bir araç haline gelmiştir. Bu çalışmanın amacı, KKN'nın sentezi, karakterizasyon teknikleri ve biyomedikal uygulamaları ile ilgili güncel literatürü bir araya getirmekti. KKN sentezi için iki tip yapay yöntem yani yukarıdan aşağıya yaklaşım ve aşağıdan yukarıya yaklaşım kullanıldı. Yukarıdan aşağıya doğru yaklaşım, ark boşaltma yöntemini, lazer ablasyon yöntemini ve elektrokimyasal yöntemi içermektedir. Öte yandan aşağıdan yukarı yaklaşım, termal yöntem, mikrodalga destekli yöntem, hidrotermal ve sulu yöntem ve kalıp yöntemini içerir. Bu derlemede, CQD'nin biyomedikal alanda son dönemdeki ilerlemesini, sentetik yöntemlerine, karakterizasyonuna ve farklı uygulamalara odaklanarak açıkladık. Karbon noktaları, in vivo ve in vitro biyolojik görüntüleme ve etken madde salım çalışmaları için kapsamlı yeterliliğe sahiptir. Karbon noktaları için daha fazla sitotoksisite araştırması yapılmasına ihtiyaç duyulmasına rağmen, önceki veriler etken madde salımı ve biyolojik görüntüleme çalışmalarında karbon noktalarının parlak geleceğini göstermektedir. Anahtar kelimeler: Karbon kuantum noktalar, nanopartiküller, kuantum verimi, karbon nokta, fotolüminesans, nanokompozitler CQD are small carbon nanoparticles smallerl than 10 nm comprising distinctive properties, which have become an obligatory tool for traceable targeted delivery, biomedical research, and different therapy applications. The objective of the present work was to consolidate the current literature on the synthesis, characterizati...

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“…12 Loading CQDs with enzyme-responsive mesoporous silica nanocarriers with a pH-switchable zwitterionic surface can be used for targeted imaging and drug delivery to tumors. 45 …”

Section: Biomedical Applications Bioimagingmentioning

confidence: 99%

Section: Targeted Drug Deliverymentioning

confidence: 99%

Section: Targeted Drug Deliverymentioning

confidence: 99%

Section: Targeted Drug Deliverymentioning

confidence: 99%

See 2 more Smart Citations

Carbon Quantum Dots: Synthesis, Characterization and Biomedical Applications

Singh

Arora

Dhiman

et al. 2018

tjps

113

View full text Add to dashboard Cite

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“…Finally, pores were loaded with DOX and closed upon the addition of PCL, which was physisorbed in pore outlets via an impregnation process. 66 At pH 6.8, the zwitterionic surface became positive due to the protonation of the carboxylic moieties and the esterase-triggered Please do not adjust margins DOX release. In the presence of esterase at a pH higher than 6.8, no release was noted due to the repulsion between the zwitteronic layer and the enzyme.…”

Section: Hydrolysis Of Ester and Phosphodiester Groupsmentioning

confidence: 99%

Mesoporous silica materials for controlled delivery based on enzymes

et al. 2017

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Actively Targeted Deep Tissue Imaging and Photothermal‐Chemo Therapy of Breast Cancer by Antibody‐Functionalized Drug‐Loaded X‐Ray‐Responsive Bismuth Sulfide@Mesoporous Silica Core–Shell Nanoparticles

Jiang

et al. 2017

Adv Funct Materials

125

100

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A theranostic platform combining synergistic therapy and real-time imaging attracts enormous attention but still faces great challenges, such as tedious modifications and lack of efficient accumulation in tumor. Here, a novel type of theranostic agent, bismuth sulfide@mesoporous silica (Bi2S3@ mPS) core-shell nanoparticles (NPs), for targeted image-guided therapy of human epidermal growth factor receptor-2 (HER-2) positive breast cancer is developed. To generate such NPs, polyvinylpyrrolidone decorated rod-like Bi2S3 NPs are chemically encapsulated with a mesoporous silica (mPS) layer and loaded with an anticancer drug, doxorubicin. The resultant NPs are then chemically conjugated with trastuzumab (Tam, a monoclonal antibody targeting HER-2 overexpressed breast cancer cells) to form Tam-Bi2S3@mPS NPs. By in vitro and in vivo studies, it is demonstrated that the Tam-Bi2S3@mPS bear multiple desired features for cancer theranostics, including good biocompatibility and drug loading ability as well as precise and active tumor targeting and accumulation (with a bismuth content in tumor being ≈16 times that of nontargeted group). They can simultaneously serve both as an excellent contrast enhancement probe (due to the presence of strong X-ray-attenuating bismuth element) for computed tomography deep tissue tumor imaging and as a therapeutic agent to destruct tumors and prevent metastasis by synergistic photothermalchemo therapy.

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Carbon‐Quantum‐Dots‐Loaded Mesoporous Silica Nanocarriers with pH‐Switchable Zwitterionic Surface and Enzyme‐Responsive Pore‐Cap for Targeted Imaging and Drug Delivery to Tumor

Cited by 69 publications

References 32 publications

Carbon Quantum Dots: Synthesis, Characterization and Biomedical Applications

Carbon Quantum Dots: Synthesis, Characterization and Biomedical Applications

Mesoporous silica materials for controlled delivery based on enzymes

Actively Targeted Deep Tissue Imaging and Photothermal‐Chemo Therapy of Breast Cancer by Antibody‐Functionalized Drug‐Loaded X‐Ray‐Responsive Bismuth Sulfide@Mesoporous Silica Core–Shell Nanoparticles

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