Carbon nanotubes increase the electrical conductivity of fibroblast-seeded collagen hydrogels

MacDonald, Rebecca A.; Voge, Christopher M.; Kariolis, Mihalis; Stegemann, Jan P.

doi:10.1016/j.actbio.2008.07.005

Cited by 131 publications

(106 citation statements)

References 33 publications

Supporting

Mentioning

103

Contrasting

Order By: Relevance

“…[26][27][28] Because SWNT and MWNT have an extremely high modulus (about 1 TPa) along their length, 29,30 their use can enhance the mechanical properties of composite scaffolds. Sen et al reported that the tensile strength of electrospun polyurethane SWNT films (about 50-100 mm in thickness) increased from 7.02 (for electrospun polyurethane) to 10.26 MPa when the weight ratio of SWNT to polyurethane was 1:100.…”

Section: Characterizationmentioning

confidence: 99%

Skeletal myotube formation enhanced by electrospun polyurethane carbon nanotube scaffolds

Sirivisoot¹,

Harrison²

2011

IJN

View full text Add to dashboard Cite

Background: This study examined the effects of electrically conductive materials made from electrospun single-or multiwalled carbon nanotubes with polyurethane to promote myoblast differentiation into myotubes in the presence and absence of electrical stimulation. Methods and results: After electrical stimulation, the number of multinucleated myotubes on the electrospun polyurethane carbon nanotube scaffolds was significantly larger than that on nonconductive electrospun polyurethane scaffolds (5% and 10% w/v polyurethane). In the absence of electrical stimulation, myoblasts also differentiated on the electrospun polyurethane carbon nanotube scaffolds, as evidenced by expression of Myf-5 and myosin heavy chains. The myotube number and length were significantly greater on the electrospun carbon nanotubes with 10% w/v polyurethane than on those with 5% w/v polyurethane. The results suggest that, in the absence of electrical stimulation, skeletal myotube formation is dependent on the morphology of the electrospun scaffolds, while with electrical stimulation it is dependent on the electrical conductivity of the scaffolds. Conclusion: This study indicates that electrospun polyurethane carbon nanotubes can be used to modulate skeletal myotube formation with or without application of electrical stimulation.

show abstract

Section: Characterizationmentioning

confidence: 99%

Skeletal myotube formation enhanced by electrospun polyurethane carbon nanotube scaffolds

Sirivisoot¹,

Harrison²

2011

IJN

View full text Add to dashboard Cite

show abstract

“…Fully swollen hydrogels with conducting particles, such as graphite, 4,11−13 carbon nanotubes, 14,15 or metallic particles, 16 incorporated in their structure typically have conductivity lower than 1 × 10 −3 S cm −1 , with mechanical properties similar to the constituent hydrogel matrix. In all of these examples, the conductivity is inversely affected by the swelling ratio, and the hydrogels exhibit brittle mechanical behavior.…”

Section: ■ Introductionmentioning

confidence: 99%

Electrically Conductive, Tough Hydrogels with pH Sensitivity

et al. 2012

View full text Add to dashboard Cite

Electrically conductive, mechanically tough hydrogels based on a double network (DN) comprised of poly(ethylene glycol) methyl ether methacrylate (PPEGMA) and poly(acrylic acid) (PAA) were produced. Poly(3,4-ethylenedioxythiophene) (PEDOT) was chemically polymerized within the tough DN gel to provide electronic conductivity. The effects of pH on the tensile and compressive mechanical properties of the fully swollen hydrogels, along with their electrical conductivity and swelling ratio were determined. Compressive and tensile strengths as high as 11.6 and 0.6 MPa, respectively, were obtained for hydrogels containing PEDOT with a maximum conductivity of 4.3 S cm -1 . This conductivity is the highest yet reported for hydrogel materials of high swelling ratios. These hydrogels may be useful as soft strain sensors because their electrical resistance changed significantly when cyclically loaded in compression. ABSTRACT: Electrically conductive, mechanically tough hydrogels based on a double network (DN) comprised of poly(ethylene glycol) methyl ether methacrylate (PPEGMA) and poly(acrylic acid) (PAA) were produced. Poly(3,4-ethylenedioxythiophene) (PEDOT) was chemically polymerized within the tough DN gel to provide electronic conductivity. The effects of pH on the tensile and compressive mechanical properties of the fully swollen hydrogels, along with their electrical conductivity and swelling ratio were determined. Compressive and tensile strengths as high as 11.6 and 0.6 MPa, respectively, were obtained for hydrogels containing PEDOT with a maximum conductivity of 4.3 S cm −1 . This conductivity is the highest yet reported for hydrogel materials of high swelling ratios. These hydrogels may be useful as soft strain sensors because their electrical resistance changed significantly when cyclically loaded in compression.

show abstract

“…[4,5] However, the electrically nonconductive nature of hydrogels impedes its use for excitable cells such as neural, skeletal and cardiac muscle, and bone cells. [6,7] To extend the utility of hydrogels, conducting 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 3 elements like metallic nanoparticles [8][9][10][11][12][13][14] and inherently conductive polymers (IHPs) [6,[15][16][17][18][19] have been incorporated within hydrogel matrices in order to add conductive properties to the 3D microenvironments.…”

Section: Introductionmentioning

confidence: 99%

Conductive gelatin methacrylate-poly(aniline) hydrogel for cell encapsulation

Sawyer

Dong

Venn

et al. 2017

Biomed. Phys. Eng. Express

View full text Add to dashboard Cite

New conductive hydrogels with superior biocompatibility continue to be developed in order to serve as bioactive scaffolds capable of modulating cellular functionality for tissue engineering applications. We developed an electrically conductive gelatin methacrylate-poly(aniline) (GelMA-PANi) hydrogel that is permissive of matrix mineralization by encapsulated osteoblast-like cells. Incorporation of PANi clusters within the GelMA matrix increases the electro-conductivity of the composite gel, while maintaining the osteoid-like soft mechanical properties that allows three-dimensional encapsulation of living cells. Viability of human osteogenic cells encapsulated within GelMA-PANi hydrogels was similar to that of GelMA. Cells within GelMA-PANi also demonstrated the capability of depositing mineral within the hydrogel matrix after being chemically induced for two weeks, although the total mineral content was lower as compared to GelMA. Additionally, we demonstrated that the GelMA-PANi-composite hydrogel could be printed in complex, user-defined geometries using digital projection stereolithography.

show abstract

Carbon nanotubes increase the electrical conductivity of fibroblast-seeded collagen hydrogels

Cited by 131 publications

References 33 publications

Skeletal myotube formation enhanced by electrospun polyurethane carbon nanotube scaffolds

Skeletal myotube formation enhanced by electrospun polyurethane carbon nanotube scaffolds

Electrically Conductive, Tough Hydrogels with pH Sensitivity

Conductive gelatin methacrylate-poly(aniline) hydrogel for cell encapsulation

Contact Info

Product

Resources

About