Carbon nanotubes in neuroregeneration and repair

Fabbro, Alessandra; Prato, Maurizio; Ballerini, Laura

doi:10.1016/j.addr.2013.07.002

Cited by 145 publications

(113 citation statements)

References 118 publications

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“…Our results are in concordance with previous reports, in the sense that functionalized multi wall carbon nanotubes can be dispersible in aqueous solution by using specific dispersants [11] [12] [13] [14] [15]. Moreover, the results presented here corroborate the results reported by others [7] [8] [10], because in these experiments MWCNTs interact with living cells and act as functional scaf folds for neuronal tissue. An interesting finding reported here, is that it was no necessary to label the MWCNTs with fluorescent compounds, as it has been done and has been reported by others [5] [16] [17] [18] [19].…”

Section: Resultssupporting

confidence: 83%

“…Fabbro et al [7] [8] found that the adhesion to carbon nanotube conductive scaffolds forced the action-potential appearance in immature rat's spinal neurons; these findings allowed them to propose that carbon nanotubes could be used for neuroregeneration and repair. Recently, Bosi et al [10] reported the elaboration of 3D nanostructured scaffolds to investigate signaling in reconstructed neuronal networks.…”

Section: Introductionmentioning

confidence: 99%

“…Sachar et al [6] reported a cytotoxic effect of single wall carbon nanotubes (SWCNTs) on erythrocytes in vitro and in vivo. On the other hand, Professor Ballerini and her group made an elegant work in which they reported that MWCNTs were bio-compatible scaffolds for growing neuronal and myocardial mammalian cells [7] [8] [9] [10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Suitability of the Composite Made of Multi Wall Carbon Nanotubes-Polyvinylpyrrolidone for Culturing Invertebrate <i>Helix aspersa</i> Neurons

Bernal-Martínez¹,

Godínez-Fernández²,

Aguilar-Elguézabal³

2017

MSCE

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Carbon nanotubes have been used as scaffolds for tissue engineering. However, the identification of these nanomaterials disperses in biological solutions and their direct interaction with nerve cells is still controversial. The aim of this work is to characterize the topographic and ultra-structural distribution of the composite made of multi wall carbon nanotubes-polyvinylpyrrolidone MWCNTs-PVP, fixing it in paraformaldehyde at 4% and was observed with SEM and CM. Although the nanotubes were not labeled or stained with fluorescent compounds, the MWCNTs-PVP deposited on glass and on nerve cells, was observed by the confocal microscope in the reflection mode. In SEM studies, it was observed that MWCNTs-PVP was attached to the surface on neurons. Moreover, in CM studies, it was possible to observe that MWCNTs-PVP was attached to the neuronal membrane, crossing the cell membrane and getting into the cytoplasm. These results support the hypothesis that carbon nanotubes interact with the neuronal cell membrane and can be useful for neuronal tissue engineering. In addition, these results open new alternatives for toxicological studies, in order to elucidate the cytotoxicity of MWCNTs-PVP composite in neurons and other excitable cells.

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Section: Resultssupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Suitability of the Composite Made of Multi Wall Carbon Nanotubes-Polyvinylpyrrolidone for Culturing Invertebrate <i>Helix aspersa</i> Neurons

Bernal-Martínez¹,

Godínez-Fernández²,

Aguilar-Elguézabal³

2017

MSCE

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“…Other materials proposed with this aim are carbon nanotubes and fibers (61,62). According with their excellent…”

Section: Canillas B Moreno-burriel E Chinarromentioning

confidence: 99%

Materials directed to implants for repairing Central Nervous System

Canillas¹,

Moreno²,

Chinarro³

2014

Bol. Soc. Esp. Ceram. Vidr.

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“…In general, the strategies for neuroregeneration should address the regrowth of injury neurites, the plastic remodelling of neuronal circuitry and/or the regeneration of new nerve cells [90] .…”

Section: Interfacial Surface Guidance Of Cps In Neuroregenerationmentioning

confidence: 99%

Bio‐Interface of Conducting Polymer‐Based Materials for Neuroregeneration

Weng

Diao

et al. 2015

Adv Materials Inter

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Nerve system diseases like Parkinson's disease, Huntington's disease, Alzheimer's disease, etc. seriously affect thousands of patients' lives every year, making them suffer from pains and inconvenience. Recently, biointerfaces between neural cells/tissues and polymer based biomaterials attracted worldwide attention due to the ability of polymer based biomaterials to serve as nerve conduits, drug carriers and neurites guidance platform in neuroregeneration. The role that bio-interface played and the way it interacted with neural tissues and cells have been thoroughly investigated by the researchers. In this paper we mainly focus on reviewing the bio-interface between nerve tissues/cells and advanced functional biocompatible polymers, such as conducting polymers and advanced carbon composite materials. These advanced polymers can provide combined interfacial stimulations including interfacial external neurotrophic factors (NTFs) delivery, electrical stimulation, surface guidance and molecules decoration to lesion cells and tissues to promote neuroregeneration in vitro and in vivo, and have contributed greatly to nerve diseases therapy. At the end of this review, the criteria of polymer based biomaterials utilized in neuroregeneration are summarized and the perspectives for future development of bio-interfaces are also discussed. Nerve system diseases like Parkinson's disease, Huntington's disease and Alzheimer's disease etc. seriously affect thousands of patients' lives every year, making the patients suffer from pains and inconvenience brought about by these diseases. Recently, bio-interface between neural cells/tissues and polymer based biomaterials attracted worldwide attention due to the ability of polymer based biomaterials to serve as nerve conduits, drug carrier and neurites guidance platform in neuroregeneration. The role that bio-interface played and the way it interacted with neural tissues and cells have been thoroughly investigated by the researchers.In this paper we mainly focus on reviewing bio-interface between nerve tissues/cells and advanced functional biocompatible polymers, such as conducting polymers and advanced carbon composites materials.. These advanced polymers can provide combined interfacial stimulations including interfacial NTFs delivery, electrical stimulation, surface guidance and molecules decoration to lesion cells and tissues to promote neuroregeneration in vitro and in vivo, and have contributed greatly to nerve diseases therapy. At the end of this review, the criteria of polymer based biomaterials utilized in neuroregeneration are summarized and the perspectives for future development of bio-interfaces are also discussed.

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Carbon nanotubes in neuroregeneration and repair

Cited by 145 publications

References 118 publications

Suitability of the Composite Made of Multi Wall Carbon Nanotubes-Polyvinylpyrrolidone for Culturing Invertebrate <i>Helix aspersa</i> Neurons

Suitability of the Composite Made of Multi Wall Carbon Nanotubes-Polyvinylpyrrolidone for Culturing Invertebrate <i>Helix aspersa</i> Neurons

Materials directed to implants for repairing Central Nervous System

Bio‐Interface of Conducting Polymer‐Based Materials for Neuroregeneration

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Carbon nanotubes in neuroregeneration and repair

Cited by 145 publications

References 118 publications

Suitability of the Composite Made of Multi Wall Carbon Nanotubes-Polyvinylpyrrolidone for Culturing Invertebrate &lt;i&gt;Helix aspersa&lt;/i&gt; Neurons

Suitability of the Composite Made of Multi Wall Carbon Nanotubes-Polyvinylpyrrolidone for Culturing Invertebrate &lt;i&gt;Helix aspersa&lt;/i&gt; Neurons

Materials directed to implants for repairing Central Nervous System

Bio‐Interface of Conducting Polymer‐Based Materials for Neuroregeneration

Contact Info

Product

Resources

About

Suitability of the Composite Made of Multi Wall Carbon Nanotubes-Polyvinylpyrrolidone for Culturing Invertebrate <i>Helix aspersa</i> Neurons

Suitability of the Composite Made of Multi Wall Carbon Nanotubes-Polyvinylpyrrolidone for Culturing Invertebrate <i>Helix aspersa</i> Neurons