Carbon Nanotubes/Carboxymethyl Chitosan/Mineralized Hydroxyapatite Composite Coating on Ti-6Al-4V Alloy for Improved Mechanical and Biological Properties

Abstract

Hydroxyapatite (HAP) is the most suitable nontoxic, biocompatible material increasingly used for bone implant coatings. However, its brittle nature is a major obstacle for such applications and this leads to the focus on developing composite coatings with the incorporation of various biopolymers and reinforcing material. In this study, mineral-substituted hydroxyapatite (M-HAP) and carboxymethyl chitosan (CMC), a biopolymer, are made into a composite (CMC/M-HAP) for enhanced biological properties of HAP. Furthermore, carbon nanotubes (CNTs) are incorporated in the composite to improve the mechanical and anticorrosive properties of HAP. The present work investigates the development of CNTs/CMC/M-HAP composite coating on piranha-treated Ti-6Al-4V alloy for improved biological and mechanical properties, which is anticipated to be the most suited alternative material for orthopedic implants.

Ball flower like manganese, strontium substituted hydroxyapatite/cerium oxide dual coatings on the AZ91 Mg alloy with improved bioactive and corrosion resistance properties for implant applications

“…19 This disadvantage has seriously restricted the medical application of Mg alloys in various elds of research. [24][25][26][27][28][29][30] More recently, the possibility to realize the substitution with at least two distinct elements has been put forward. 17 In response to this, calcium phosphate based bioceramic coatings have been suggested as a mean of preventing exposure to the corrosive environment.…”

Graphene as an Enabling Strategy for Dental Implant and Tissue Regeneration

“…Improved adhesion, cell viability, and good biocompatibility [56] Detonation nanodiamonds of each other using the LbL assembly, with the substrate composed of 15 bilayers. The BMP-2 could then be loaded on the outermost coating layer of GO-COO -, and sustainably released.…”

Polymeric nanobiocomposites for biomedical applications

“…Among these fillers, carbon nanotubes have extensively been used for dental and orthopedic application owing to their superior ability to enhance mechanical properties, such as elastic modulus, young modulus, tensile strength upon addition of only minimal amount as less as 0.1% to the composites. 162,169,170 Similarly, other metal oxides, such as titanium dioxide and silver bromide are considered as dual actions tunable nanomaterials due to their ability to not only increase mechanical properties but also to act as excellent anti-microbial agents. 95,162 Another such example would be hydroxyapatite whiskers or nanofibers, which are to be incorporated into dental resins in order to enhance the biocompatibility of the nanobiocomposites.…”