Graphene as an Enabling Strategy for Dental Implant and Tissue Regeneration

Park, Chan; Park, Sunho; Lee, Dohyeon; Choi, Kyoung Soon; Lim, Hyun-Pil; Kim, Jangho

doi:10.1007/s13770-017-0052-3

Cited by 37 publications

(27 citation statements)

References 100 publications

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“…However, in the sintered samples, this correlation did not hold up, since the higher y -carbon level in sample LTS SPS (0.0114) than in the sample LTS + (hBN) 0.01 SPS (0.0076) induced a lower microstrain of 0.12% vs. 0.14%, respectively. The amount of carbon, a biocompatible material, was very low in the sintered samples [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

Sintered and 3D-Printed Bulks of MgB2-Based Materials with Antimicrobial Properties

et al. 2021

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Pristine high-density bulk disks of MgB2 with added hexagonal BN (10 wt.%) were prepared using spark plasma sintering. The BN-added samples are machinable by chipping them into desired geometries. Complex shapes of different sizes can also be obtained by the 3D printing of polylactic acid filaments embedded with MgB2 powder particles (10 wt.%). Our present work aims to assess antimicrobial activity quantified as viable cells (CFU/mL) vs. time of sintered and 3D-printed materials. In vitro antimicrobial tests were performed against the bacterial strains Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 25923, Enterococcus faecium DSM 13590, and Enterococcus faecalis ATCC 29212; and the yeast strain Candida parapsilosis ATCC 22019. The antimicrobial effects were found to depend on the tested samples and microbes, with E. faecium being the most resistant and E. coli the most susceptible.

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Section: Resultsmentioning

confidence: 99%

Sintered and 3D-Printed Bulks of MgB2-Based Materials with Antimicrobial Properties

et al. 2021

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“…Graphene was used as coating in a titanium implant, enhancing calcium deposition and osteoinduction, and as a stem cell recruitment agent, improving quality and quantity of bone around and in contact with the implant [ 33 ]. Graphene coating also improved the anti-corrosion properties of titanium [ 34 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Graphene-Doped Poly (Methyl-Methacrylate) (Pmma) Implants: A Micro-CT and Histomorphometrical Study in Rabbits

Orsini

Carlo

Valbonetti

et al. 2021

IJMS

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Background—the graphene-doping procedure represents a useful procedure to improve the mechanical, physical and biological response of several Polymethyl methacrylate (PMMA)-derived polymers and biomaterials for dental applications. The aim of this study was to evaluate osseointegration of Graphene doped Poly(methyl methacrylate) (GD-PMMA) compared with PMMA as potential materials for dental implant devices. Methods—eighteen adult New Zealand white male rabbits with a mean weight of approx. 3000 g were used in this research. A total of eighteen implants of 3.5 mm diameter and 11 mm length in GD-PMMA and eighteen implants in PMMA were used. The implants were placed into the articular femoral knee joint. The animals were sacrificed after 15, 30 and 60 days and the specimens were evaluated by µCT and histomorphometry. Results—microscopically, all 36 implants, 18 in PMMA and 18 in DG-PMMA were well-integrated into the bone. The implants were in contact with cortical bone along the upper threads, while the lower threads were in contact with either newly formed bone or with marrow spaces. The histomorphometry and µCT evaluation showed that the GP-PMMA and PMMA implants were well osseointegrated and the bone was in direct contact with large portions of the implant surfaces, including the space in the medullary canal. Conclusions—in conclusion, the results suggest that GD-PMMA titanium surfaces enhance osseointegration in rabbit femurs. This encourages further research to obtain GD-PMMA with a greater radiopacity. Also, further in vitro and vivo animal studies are necessary to evaluate a potential clinical usage for dental implant applications.

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“…The properties of GO/PMMA make this material advantageous for potential applications as screws or implants fixation. Previous studies [ 25 , 40 ] showed that PMMA filled with GO conforms to physicochemical and mechanical demands of these clinical applications. In this study, we have shown that incorporation of GO into PMMA matrix may provide an additional functionality to the resulting composite material, enhancing its biocompatibility through facilitating osteogenesis.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Osteogenic Differentiation of Human Primary Mesenchymal Stem and Progenitor Cultures on Graphene Oxide/Poly(methyl methacrylate) Composite Scaffolds

et al. 2020

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Due to its versatility, small size, large surface area, and ability to interact with biological cells and tissues, graphene oxide (GO) is an excellent filler for various polymeric composites and is frequently used to expand their functionality. Even though the major advantage of the incorporation of GO is the enhancement of mechanical properties of the composite material, GO is also known to improve bioactivity during biomineralization and promote osteoblast adhesion. In this study, we described the fabrication of a composite bone cement made of GO and poly(methyl methacrylate) (PMMA), and we investigated its potential to enhance osteogenic differentiation of human primary mesenchymal stem and progenitor cells. Through the analysis of three differentiation markers, namely alkaline phosphatase, secreted protein acidic and rich in cysteine, and bone morphogenetic protein-2 in the presence and in the absence of an osteogenic differentiation medium, we were able to indicate a composite produced manually with a thick GO paper as the most effective among all investigated samples. This effect was related to its developed surface, possessing a significant number of voids and pores. In this way, GO/PMMA composites were shown as promising materials for the applications in bone tissue engineering.

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Graphene as an Enabling Strategy for Dental Implant and Tissue Regeneration

Cited by 37 publications

References 100 publications

Sintered and 3D-Printed Bulks of MgB2-Based Materials with Antimicrobial Properties

Sintered and 3D-Printed Bulks of MgB2-Based Materials with Antimicrobial Properties

Graphene-Doped Poly (Methyl-Methacrylate) (Pmma) Implants: A Micro-CT and Histomorphometrical Study in Rabbits

Enhanced Osteogenic Differentiation of Human Primary Mesenchymal Stem and Progenitor Cultures on Graphene Oxide/Poly(methyl methacrylate) Composite Scaffolds

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