Carbon monoxide-triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes

Chen, Rong Jane; Lee, Yu-Hsuan; Chen, Tzu Hao; Chen, Yu Ying; Yeh, Ya Ling; Chang, Ching‐Ping; Huang, Chun‐Yen; Guo, How‐Ran; Wang, Ying Jan

doi:10.1007/s00204-021-02976-7

Cited by 18 publications

(17 citation statements)

References 148 publications

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“…Carbon monoxide (CO) exposure is an established approach to reduce tissue oxygenation, which has been linked to cytoprotective effects as well as oxidative stress induction. 138 , 139 Although various positive effects were observed ( Supplementary Table 2 ), chronic CO exposure induced hyperintense lesions in the caudoputamen region of the brain in Ndufs4 −/− -WB mice, indicative of adverse effects. 137 Similarly, hypoxic conditions prevented/mitigated part of the disease phenotype in Ndufs4 −/− -WB mice (prolonged lifespan, no loss of body weight, improved motor function, prevention of hypothermia).…”

Section: Intervention Studies In Ndufs4 Mouse Modelsmentioning

confidence: 99%

Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention

Wal

Adjobo‐Hermans

Keijer

et al. 2021

Brain

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Mitochondria are small cellular constituents that generate cellular energy (ATP) by oxidative phosphorylation (OXPHOS). Dysfunction of these organelles is linked to a heterogeneous group of multisystemic disorders, including diabetes, cancer, ageing-related pathologies and rare mitochondrial diseases (MDs). With respect to the latter, mutations in subunit-encoding genes and assembly factors of the first OXPHOS complex (CI) induce isolated CI deficiency and Leigh syndrome (LS). This syndrome is an early-onset, often fatal, encephalopathy with a variable clinical presentation and poor prognosis due to the lack of effective intervention strategies. Mutations in the nuclear DNA (nDNA)-encoded NDUFS4 gene, encoding the NADH: Ubiquinone oxidoreductase subunit S4 (NDUFS4) of CI induce “mitochondrial complex I deficiency, nuclear type 1” (MC1DN1) and LS in pediatric patients. A variety of (tissue-specific) Ndufs4 knockout mouse models were developed to study the LS pathomechanism and intervention testing. Here, we review and discuss the role of CI and NDUFS4 mutations in human MD, and review how the analysis of Ndufs4 knockout mouse models has generated new insights into the MC1ND1/LS pathomechanism and its therapeutic targeting.

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Section: Intervention Studies In Ndufs4 Mouse Modelsmentioning

confidence: 99%

Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention

Wal

Adjobo‐Hermans

Keijer

et al. 2021

Brain

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“…Carbon monoxide can activate the NLRP3 pathway and the secretion of exosomes (Chen et al, 2021). Betaine inhibits the extracellular secretion of secretory lysosomes containing IL-1β, then inhibits the extracellular secretion of IL-1β-containing exosomes, thereby inhibiting IL -1β release (Xia et al, 2018).…”

Section: Nlrp3 Downstream Exosomes Release-inflammation and More Than Inflammationmentioning

confidence: 99%

“…Sarkar et al found that Mn 2+ can induce cell-to-cell transfer of the inflammasome adaptor protein ASC in exosomes, which might be a potential mechanism in neurodegenerative diseases ( Sarkar et al, 2019 ). Carbon monoxide can activate the NLRP3 pathway and the secretion of exosomes ( Chen et al, 2021 ). Betaine inhibits the extracellular secretion of secretory lysosomes containing IL-1β, then inhibits the extracellular secretion of IL-1β-containing exosomes, thereby inhibiting IL -1β release ( Xia et al, 2018 ).…”

Section: Exosome and Nlrp3 Inflammasome Activation Pathwaysmentioning

confidence: 99%

Exosomes Regulate NLRP3 Inflammasome in Diseases

Chen

Tao

et al. 2022

Front. Cell Dev. Biol.

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Emerging evidence has suggested the unique and critical role of exosomes as signal molecules vector in various diseases. Numerous researchers have been trying to identify how these exosomes function in immune progression, as this could promote their use as biomarkers for the disease process and potential promising diagnostic tools. NOD-like receptor (NLR) family, pyrin domain containing 3 (NLRP3), a tripartite protein, contains three functional domains a central nucleotide-binding and oligomerization domain (NACHT), an N-terminal pyrin domain (PYD), and a leucine-rich repeat domain (LRR). Of note, existing studies have identified exosome as a novel mediator of the NLRP3 inflammasome, which is critical in diseases progression. However, the actual mechanisms and clinical treatment related to exosomes and NLRP3 are still not fully understood. Herein, we presented an up-to-date review of exosomes and NLRP3 in diseases, outlining what is known about the role of exosomes in the activation of NLRP3 inflammasome and also highlighting areas of this topic that warrant further study.

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“…CO can interfere the oxygen-carrying by Hb to vital organs and tissues, causing stress that lead to organ's malfunction and failure (Chen et al, 2021;Röhrig, 2016) and O 2 compete for binding to hemoglobin. CO binds longer than oxygen, which easy to break away from hemoglobin (Dewanti, 2018).…”

Section: The Effect Of Anti-mosquitos On Co-hbmentioning

confidence: 99%

Toxicology properties of commercial anti‐mosquitos and their effects on carboxyhemoglobin and malondialdehyde levels

Andini

Sunaryo

Ayu

et al. 2022

Environmental Quality Mgmt

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Exposure of carbon monoxide (CO) released by insect repellent has a negative impact on health by forming carboxyhemoglobin (CO-Hb) as a trigger for oxidative stress in the human body. Therefore, the objective of the study was to investigate the effect of commercial anti-mosquitos on CO-Hb and malondialdehyde (MDA) levels in the blood.Effect of electric spray, coils, and electric mats on CO-Hb and MDA levels in blood was evaluated using male Wistar rats (8 h per day) and monitored for 20 days. The study found that the highest increase in CO-Hb and CO-Hb levels in the blood was observed when exposed to electric spray formula compared to other anti-mosquitos. In addition, the highest increase in MDA levels also occurred when exposed to the electric spray.Statistical analysis revealed that there was a significant relationship between CO-Hb and MDA levels in the blood (p-value = 0.000). High CO-Hb levels in the blood could stimulate oxidative stress and lead to cell damage in the body.

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Carbon monoxide-triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes

Cited by 18 publications

References 148 publications

Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention

Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention

Exosomes Regulate NLRP3 Inflammasome in Diseases

Toxicology properties of commercial anti‐mosquitos and their effects on carboxyhemoglobin and malondialdehyde levels

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