Abstract:Cigarette smoke is known to interfere with the pulmonary metabolism of arachidonic acid and prostaglandin E2 (PGE2). We investigated the possible role of carbon monoxide in these cigarette smoke‐induced alterations. 14C‐Arachidonic acid (50 nmol) was infused into the pulmonary circulation of isolated perfused hamster lungs, and the radioactive metabolites in the perfusion effluent, as well as the distribution of incorporated radioactive arachidonic acid within the lung lipids, were analysed. Carbon monoxide, a… Show more
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