Involvement of prostanoids in cigarette smoking-induced pathophysiological effects in the lung

Lee, Lu-Yuan; Hong, Jeff

doi:10.1054/plef.1999.0084

Cited by 2 publications

(1 citation statement)

References 131 publications

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“…These results indicate that smoking (and not some mechanism specific for COPD) could be the single or most important stimulus for an inflammatory infiltrate with high levels of certain cyclooxygenase products. 11 Fluticasone propionate (FP) had no significant effect on BAL cellularity or on protein and albumin levels (Table 2). Apparently, the influx and the survival of cells were not affected by this potent topical glucocorticoid.…”

Section: Discussionmentioning

confidence: 98%

Effects of fluticasone propionate inhalation on levels of arachidonic acid metabolites in patients with chronic obstructive pulmonary disease

Verhoeven

Garrelds

Hoogsteden

et al. 2001

Mediators of Inflammation

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BACKGROUND: In smoking COPD patients the bronchoalveolar lavage (BAL) fluid contains high numbers of inflammatory cells. These cells might produce arachidonic acid (AA) metabolites, which contribute to inflammation and an increased bronchomotor tone. AIMS: To investigate levels of AA metabolites in BAL fluid, before and after inhaled glucocorticoid therapy: fluticasone propionate (FP) 1 mg per day, or placebo. METHODS: A double-blind placebo controlled trial lasting six months. COPD patients were selected by clinical criteria and the presence of bronchial hyper-responsiveness (BHR). Lung function was recorded and in BAL fluid we counted cell numbers and measured LTB4, LTC4/D4/E4, PGE2, 6kPGF1alpha, PGF2alpha and TxB2. A control group consisted of asymptomatic smokers (n=6). RESULTS: Paired data were obtained from 9 FP treated and 11 placebo patients. BAL cells were almost exclusively alveolar macrophages. In patients and controls both cellularity and levels of AA metabolites were equal Cell numbers did not change after treatment. Statistically significant decreases after FP therapy were noticed for PGE2 (30%), 6kPGF1alpha (41%) and PGF2alpha (54%). CONCLUSIONS: In COPD, the capability of inflammatory cells to produce certain AA metabolites was decreased after inhaled FP treatment. This result is discussed in its relation to clinical effects, the influence of smoking, and the results of an earlier, similar study in asthma patients.

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Section: Discussionmentioning

confidence: 98%

Effects of fluticasone propionate inhalation on levels of arachidonic acid metabolites in patients with chronic obstructive pulmonary disease

Verhoeven

Garrelds

Hoogsteden

et al. 2001

Mediators of Inflammation

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Perioperative Abstinence from Cigarettes

Warner¹,

Warltier²

2006

Anesthesiology

215

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Chronic exposure to cigarette smoke produces profound changes in physiology that may alter responses to perioperative interventions and contribute to perioperative morbidity. Because of smoke-free policies in healthcare facilities, all smokers undergoing surgery are abstinent from cigarettes for at least some period of time so that all are in various stages of recovery from the effects of smoke. Understanding this recovery process will help perioperative physicians better treat these patients. This review examines current knowledge regarding how both short-term (duration ranging from hours to weeks) and long-term smoking cessation affects selected physiology and pathophysiology of particular relevance to perioperative outcomes and how these changes affect perioperative risk. It will also consider current evidence regarding how nicotine replacement therapy, a valuable adjunct to help patients maintain abstinence, may affect perioperative physiology.

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Involvement of prostanoids in cigarette smoking-induced pathophysiological effects in the lung

Cited by 2 publications

References 131 publications

Effects of fluticasone propionate inhalation on levels of arachidonic acid metabolites in patients with chronic obstructive pulmonary disease

Effects of fluticasone propionate inhalation on levels of arachidonic acid metabolites in patients with chronic obstructive pulmonary disease

Perioperative Abstinence from Cigarettes

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