Carbapenem-resistant Klebsiella pneumoniae is associated with poor outcome in hemodialysis patients

Bleumin, Dina; Cohen, Matan J.; Moranne, Olivier; Esnault, Vincent; Benenson, Shmuel; Paltiel, Ora; Tzukert, Keren; Levi, Irit Mor‐Yosef; Ben‐Dov, Iddo Z.; Levi, R.; Bloch, Aharon; Haviv, Yosef S.

doi:10.1016/j.jinf.2012.06.005

Cited by 31 publications

(26 citation statements)

References 48 publications

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“…In other studies, mortality ranged from 14% up to 88% depending on the presence of the aforementioned factors. 26,27 Treatment failure was the only independent predictor of mortality in the multivariate analysis. Common predictors of mortality reported in other studies (mainly co-morbidity, severity scores, specific antibiotic classes, MDR or XDR bacteria, and ICU stay) were not associated with mortality in the present study.…”

Section: Discussionmentioning

confidence: 90%

Characteristics, risk factors and outcomes of carbapenem-resistant Klebsiella pneumoniae infections in the intensive care unit

Vardakas

Matthaiou

Falagas

et al. 2015

Journal of Infection

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Section: Discussionmentioning

confidence: 90%

Characteristics, risk factors and outcomes of carbapenem-resistant Klebsiella pneumoniae infections in the intensive care unit

Vardakas

Matthaiou

Falagas

et al. 2015

Journal of Infection

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“…A methodological concern in studies that compare the mortality and morbidity of patients infected with resistant bacteria to other patients is that the former group tends to have additional risk factors, such as more severe underlying illness and longer hospitalization, which make them more likely to have worse outcomes. Most well‐designed studies that controlled for these potential confounders found 3–6 times higher mortality among CRE‐infected patients than those either infected with carbapenem‐susceptible Enterobacteriaceae or without CRE infection, although another study found no difference …”

Section: Clinical Manifestations Of Crementioning

confidence: 99%

Carbapenem‐resistant Enterobacteriaceae: biology, epidemiology, and management

Temkin

Adler

Lerner

et al. 2014

Annals of the New York Academy of Sciences

194

167

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Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug-resistant Gram-negative organisms. Over the last decade, carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat. This review summarizes the molecular genetics, natural history, and epidemiology of CRE and discusses approaches to prevention and treatment.

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“…is among the most common pathogens isolated in ICUs [2]. It is currently the fourth most common cause of pneumonia and the fifth most common cause of bacteraemia in intensive care patients [3]. Its principal nosocomial reservoirs are contaminated medical equipment, the hands of hospital staff and the gastrointestinal tract of patients [4].…”

Section: Introductionmentioning

confidence: 99%

An overview of carbapenem-resistant Klebsiella pneumoniae

Spagnolo

Orlando

Panatto

et al. 2014

Reviews in Medical Microbiology

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The emergence and dissemination of carbapenem resistance among Enterobacteriaceae, especially Klebsiella pneumoniae, constitute a serious threat to public health, since carbapenems are the agents of last resort in the treatment of life-threatening infections caused by drug-resistant Enterobacteriaceae. In K. pneumoniae, carbapenem resistance was first reported a decade ago and has subsequently emerged in several countries. One particular group of transmissible plasmid-encoded carbapenemase enzymes, designated K. pneumoniae carbapenemase (KPC), confers carbapenem resistance to K. pneumoniae strains and is rapidly spreading worldwide.In addition to KPC-producing K. pneumoniae, several different metallo-b-lactamaseproducing strains have been identified. These include New Delhi metallo-b-lactamase, Verona integron-encoded metallo-b-lactamase and imipenemase metallo-b-lactamase. Finally, class D carbapenemases, including oxacillin-type carbapenemases, also occur in K. pneumoniae.Carbapenem-resistant K. pneumoniae (CRKP) can cause several types of healthcareassociated infections, including pneumonia, bloodstream infections, wound or surgical site infections, urinary tract infections and meningitis, and is associated with high mortality rates.Multifactorial intervention, including hand hygiene, contact precautions, patient and staff cohorting, minimizing invasive device use, promoting antimicrobial stewardship, screening, active surveillance testing and chlorhexidine bathing, may be an effective strategy for reducing the nosocomial transmission of CRKP. Moreover, the rapid notification of clinical infection whenever CRKP are identified from clinical specimens allows the timely implementation of control measures. ß

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Carbapenem-resistant Klebsiella pneumoniae is associated with poor outcome in hemodialysis patients

Cited by 31 publications

References 48 publications

Characteristics, risk factors and outcomes of carbapenem-resistant Klebsiella pneumoniae infections in the intensive care unit

Characteristics, risk factors and outcomes of carbapenem-resistant Klebsiella pneumoniae infections in the intensive care unit

Carbapenem‐resistant Enterobacteriaceae: biology, epidemiology, and management

An overview of carbapenem-resistant Klebsiella pneumoniae

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