Caracterização morfológica de piperáceas nativas conservadas em casa de vegetação

Rito, Danielle Santana; VIEIRA, Eduardo Filipe Torres; Menezes, I. C. de; Lameira, O. A.; Poltronieri, M. C.; Lemos, O. F. de; Rodrigues, S. de M.

doi:10.33448/rsd-v10i6.15686

Cited by 2 publications

(1 citation statement)

References 20 publications

(18 reference statements)

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“…The Piperaceae family comprises 5 known genera (Macropiper, Zippelia, Manekia, Peperomia and Piper) with approximately 3,700 species distributed around the world, occurring mainly throughout the tropical region, usually in shady places (Brito and Pereira, 2019). In Brazil, the Piperaceae family is represented by the genera Manekia, Peperomia and Piper, the latter two having the highest number of known species (RITO et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

FRAGMENTATION EFFECT OF GREEN LEAVES AND SEEDS BLACK PEPPER (Pipernigrum) ON ESSENTIAL OIL INDEX

Bandiera¹,

Krinski²

2022

JASR

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The Piperaceae family comprises 5 known genera (Macropiper, Zippelia, Manekia, Peperomia, and Piper). The species PipernigrumL is known as black pepper or black pepper and in the Brazilian market it is widely used in the sausage, perfumery and pharmaceutical industries. In addition to industrial, pharmaceutical and food use, the essential oil (EO) of P.nigrum stands out due to its biological properties. Therefore, this work aimed to extract and quantify green black pepper leaves and seeds and compare the content and yield of extractions using different processing of these plant parts (whole and crushed).). For this, leaves and green peppers of P. nigrum were collected in the municipality of Tangará da Serra/MT for hydrodistillation of their EO using Clevenger apparatus for 4 h. As a result, it was found that theThe values of content and average yields extracted from seeds were almost five times higher when whole seeds were used. The amount of EO extracted from the leaves did not show significant differences between the extractions performed with whole and crushed leaves.

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Section: Introductionmentioning

confidence: 99%

FRAGMENTATION EFFECT OF GREEN LEAVES AND SEEDS BLACK PEPPER (Pipernigrum) ON ESSENTIAL OIL INDEX

Bandiera¹,

Krinski²

2022

JASR

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Computational Predictive and Electrochemical Detection of Metabolites (CP-EDM) of Piperine

Asra,

Povinelli,

Zazeri

et al. 2024

Molecules

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In this article, we introduce a proof-of-concept strategy, Computational Predictive and Electrochemical Detection of Metabolites (CP-EDM), to expedite the discovery of drug metabolites. The use of a bioactive natural product, piperine, that has a well-curated metabolite profile but an unpredictable computational metabolism (Biotransformer v3.0) was selected. We developed an electrochemical reaction to oxidize piperine into a range of metabolites, which were detected by LC-MS. A series of chemically plausible metabolites were predicted based on ion fragmentation patterns. These metabolites were docked into the active site of CYP3A4 using Autodock4.2. From the clustered low-energy profile of piperine in the active site, it can be inferred that the most likely metabolic position of piperine (based on intermolecular distances to the Fe-oxo active site) is the benzo[d][1,3]dioxole motif. The metabolic profile was confirmed by comparison with the literature, and the electrochemical reaction delivered plausible metabolites, vide infra, thus, demonstrating the power of the hyphenated technique of tandem electrochemical detection and computational evaluation of binding poses. Taken together, we outline a novel approach where diverse data sources are combined to predict and confirm a metabolic outcome for a bioactive structure.

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Caracterização morfológica de piperáceas nativas conservadas em casa de vegetação

Cited by 2 publications

References 20 publications

FRAGMENTATION EFFECT OF GREEN LEAVES AND SEEDS BLACK PEPPER (Pipernigrum) ON ESSENTIAL OIL INDEX

FRAGMENTATION EFFECT OF GREEN LEAVES AND SEEDS BLACK PEPPER (Pipernigrum) ON ESSENTIAL OIL INDEX

Computational Predictive and Electrochemical Detection of Metabolites (CP-EDM) of Piperine

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