Capsiate improves glucose metabolism by improving insulin sensitivity better than capsaicin in diabetic rats

The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial

“…In agreement with our study, the consumption of green tea for 6 months resulted in improved glucose homeostasis in overweight breast cancer survivors [34]. Furthermore, capsaicin intake improved glucose homeostasis in diabetic rats [35]. A 3-month supplementation with 3 g/day ginger also improved glycemic indices in patients with T2DM [36].…”

“…Insulin resistance is considered to be responsible for the development of all constituents of the metabolic syndrome, which in turn may have cardiovascular and metabolic consequences [39]. Green tea, capsaicin and ginger intake may improve markers of insulin metabolism through increased AMP-activated protein kinase activation, modulating the expression of genes involved in metabolism, particularly in adipose tissue [40] and decreasing apoptosis of β-cells by potentiating insulin/IGF-1 signaling [35]. The discrepancies between findings of this study and those of previous reports might be explained by doses of green tea, capsaicin and ginger supplements used, the intervention time, clinical characteristics of the participants such as variation in baseline levels of metabolic profiles.…”

<b><i>TRPV1</i></b> Gene Polymorphisms Are Associated with Type 2 Diabetes by Their Interaction with Fat Consumption in the Korean Genome Epidemiology Study

“…However, there have been no studies of transient receptor potential vanilloid 1 (TRPV1) genotypes and type 2 diabetes, even though TRPV1 is involved in energy and glucose metabolism [8,9]. TRPV1 transduction delivers the signals of noxious stimuli, including heat, acids, pollutants with negative charges, and endogenous proinflammatory substances [10,11,12].…”

“…TRPV1 is expressed in most tissues such as adipocytes, hepatocytes, skeletal muscles, and β-cells [13]. The activation of TRPV1 by capsaicin increases energy expenditure and fat oxidation, thereby suppressing the storage of energy as fat mass [9,14]. In addition, TRPV1 activation increases insulin sensitivity and potentiates glucose-stimulated insulin secretion, thereby compensating for insulin resistance in type 2 diabetic animal models [9,10].…”

“…The activation of TRPV1 by capsaicin increases energy expenditure and fat oxidation, thereby suppressing the storage of energy as fat mass [9,14]. In addition, TRPV1 activation increases insulin sensitivity and potentiates glucose-stimulated insulin secretion, thereby compensating for insulin resistance in type 2 diabetic animal models [9,10]. Acute capsaicin administration increases glucagon-like peptide-1 (GLP-1) and insulin secretion in wild-type mice but not in TRPV1 -/- mice, whereas chronic consumption of capsaicin improves glucose tolerance with potentiated GLP-1 and insulin secretion in normal and diabetic mice [9,15].…”