“…Subclinical hypothyroidism is characterized by abnormal lipid metabolism, cardiac dysfunction, diastolic hypertension conferring an elevated risk of atherosclerosis, and ischemic heart disease [1]. It has been reported that subclinical hypothyroidism is associated with both, a significant risk of coronary heart disease [20] at baseline and at followup and that mortality from cardiovascular causes is significantly higher at follow-up [21][22][23][24]. However subclinical thyroid dysfunction is currently the subject of numerous studies and remains controversial, particularly as it relates to cardiovascular morbidity and mortality and clinical applications [1,25,26,27].…”