A case of acute myocardial infarction due to the use of cayenne pepper pills

Sayın, Muhammet Raşit; Karabağ, Turgut; Dogan, Sait Mesut; Akpınar, İbrahim; Aydın, Mustafa

doi:10.1007/s00508-012-0163-8

Cited by 15 publications

(12 citation statements)

References 10 publications

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“…For example, cinnamon ingestion 12 h before the blood sampling or even simultaneous with blood sampling causes a significant decrease of blood glucose and improves insulin sensitivity [17]. Weight loss pills containing cayenne pepper, bitter orange and amphetamine have been demonstrated to lead to myocardial injury accompanied by an increase in concentrations of troponin and CK-MB through the activation of the sympathetic nervous system [18][19][20][21]. Consumption of red rice and green tea extract have been associated with liver enzyme abnormalities [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Patient’s knowledge and awareness about the effect of the over-the-counter (OTC) drugs and dietary supplements on laboratory test results: a survey in 18 European countries

Šimundić¹,

Filipi

Vrtarić

et al. 2018

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background Nowadays over-the-counter (OTC) drugs and dietary supplements are widely used. Their use can have a significant impact on the validity of laboratory results. The aim of this multicenter European study was to determine the frequency of consumption of various dietary products and OTC drugs among patients and explore their level of knowledge and awareness about the potential impact of various products on laboratory test results. Methods Eighteen European countries participated in this study. The survey was carried out anonymously on a subsequent series of outpatients (n=200) in each participating country. Included were patients who were referred to the laboratory for blood sampling and who voluntarily agreed to participate in the study. The survey included questions about the frequency of consumption of various products, awareness of the importance of informing physicians and laboratory staff about it and information about influence of preanalytical factors in general on laboratory test results. Results In total, 68% of patients were regularly taking at least one OTC drug or dietary supplement. The frequency of patients consuming at least one OTC drug or dietary supplement differed between countries (p=0.001). Vitamins (38%), minerals (34%), cranberry juice (20%), acetylsalicylic acid (ASA) (17%) and omega fatty acids (17%) were the most commonly used in our study. Conclusions The use of various OTC drugs and dietary supplements is highly prevalent in Europe and patients are often not willing to disclose this information to the laboratory staff and ordering physician. The education of both patients and healthcare staff is needed.

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Section: Discussionmentioning

confidence: 99%

Patient’s knowledge and awareness about the effect of the over-the-counter (OTC) drugs and dietary supplements on laboratory test results: a survey in 18 European countries

Šimundić¹,

Filipi

Vrtarić

et al. 2018

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…Even a small change in heart rate may be detrimental if a person is having an acute myocardial infarction. Case reports also suggest that excessive consumption of cayenne pepper (the active component of which is capsaicin) can result in myocardial infarction due to coronary vasospasm . Consequently, direct agonists and antagonists of the TRPV1 channel have substantial disadvantages over indirect modulation, as described with V1‐cal.…”

Section: Discussionmentioning

confidence: 99%

Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury

Hurt

Stary

et al. 2016

JAHA

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BackgroundThe transient receptor potential vanilloid 1 (TRPV1) mediates cellular responses to pain, heat, or noxious stimuli by calcium influx; however, the cellular localization and function of TRPV1 in the cardiomyocyte is largely unknown. We studied whether myocardial injury is regulated by TRPV1 and whether we could mitigate reperfusion injury by limiting the calcineurin interaction with TRPV1.Methods and ResultsIn primary cardiomyocytes, confocal and electron microscopy demonstrates that TRPV1 is localized to the mitochondria. Capsaicin, the specific TRPV1 agonist, dose‐dependently reduced mitochondrial membrane potential and was blocked by the TRPV1 antagonist capsazepine or the calcineurin inhibitor cyclosporine. Using in silico analysis, we discovered an interaction site for TRPV1 with calcineurin. We synthesized a peptide, V1‐cal, to inhibit the interaction between TRPV1 and calcineurin. In an in vivo rat myocardial infarction model, V1‐cal given just prior to reperfusion substantially mitigated myocardial infarct size compared with vehicle, capsaicin, or cyclosporine (24±3% versus 61±2%, 45±1%, and 49±2%, respectively; n=6 per group; P<0.01 versus all groups). Infarct size reduction by V1‐cal was also not seen in TRPV1 knockout rats.Conclusions TRPV1 is localized at the mitochondria in cardiomyocytes and regulates mitochondrial membrane potential through an interaction with calcineurin. We developed a novel therapeutic, V1‐cal, that substantially reduces reperfusion injury by inhibiting the interaction of calcineurin with TRPV1. These data suggest that TRPV1 is an end‐effector of cardioprotection and that modulating the TRPV1 protein interaction with calcineurin limits reperfusion injury.

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“…If ingested in large amounts, capsaicin can cause nausea, vomiting, abdominal pain, and burning diarrhea (Srinivasan, 2015). Although case studies have suggested a link with adverse cardiovascular events when consuming red pepper (Sayin et al, 2012), no adverse effects have ever been shown to be directly associated with capsaicin, and various studies have indicated cardioprotective and chemoprotective effects (Srinivasan, 2015).…”

Section: Capsaicin and Capsiatementioning

confidence: 99%

A Review of Natural Stimulant and Non‐stimulant Thermogenic Agents

Stohs

Badmaev

2016

Phytotherapy Research

104

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Obesity and overweight are major health issues. Exercise and calorie intake control are recognized as the primary mechanisms for addressing excess body weight. Naturally occurring thermogenic plant constituents offer adjunct means for assisting in weight management. The controlling mechanisms for thermogenesis offer many intervention points. Thermogenic agents can act through stimulation of the central nervous system with associated adverse cardiovascular effects and through metabolic mechanisms that are non‐stimulatory or a combination thereof. Examples of stimulatory thermogenic agents that will be discussed include ephedrine and caffeine. Examples of non‐stimulatory thermogenic agents include p‐synephrine (bitter orange extract), capsaicin, forskolin (Coleus root extract), and chlorogenic acid (green coffee bean extract). Green tea is an example of a thermogenic with the potential to produce mild but clinically insignificant undesirable stimulatory effects. The use of the aforementioned thermogenic agents in combination with other extracts such as those derived from Salacia reticulata, Sesamum indicum, Lagerstroemia speciosa, Cissus quadrangularis, and Moringa olifera, as well as the use of the carotenoids as lutein and fucoxanthin, and flavonoids as naringin and hesperidin can further facilitate energy metabolism and weight management as well as sports performance without adverse side effects. © 2016 The Authors Phytotherapy Research published by John Wiley & Sons Ltd.

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A case of acute myocardial infarction due to the use of cayenne pepper pills

Cited by 15 publications

References 10 publications

Patient’s knowledge and awareness about the effect of the over-the-counter (OTC) drugs and dietary supplements on laboratory test results: a survey in 18 European countries

Patient’s knowledge and awareness about the effect of the over-the-counter (OTC) drugs and dietary supplements on laboratory test results: a survey in 18 European countries

Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury

A Review of Natural Stimulant and Non‐stimulant Thermogenic Agents

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