Capsaicin and arterial hypertensive crisis

Patanè, Salvatore; Marte, Filippo; Rosa, Felice Carmelo La; Rocca, Roberto La

doi:10.1016/j.ijcard.2008.12.080

Cited by 17 publications

(11 citation statements)

References 6 publications

(6 reference statements)

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“…Table 2A shows comparisons with day 1 whereas Table 2B compares the groups. In a recent case report, patient consuming pepper in a large quantity manifested with hypertensive crisis [2]. Pepper contains an active ingredient, capsaicin and the hypertensive crisis in this report has been attributed to it.…”

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confidence: 55%

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Mechanisms underlying the hypertensive response induced by capsaicin

Dutta

Deshpande

2010

International Journal of Cardiology

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confidence: 55%

“…The authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International Journal of Cardiology [2]. Table 2 Comparison of artrial fibrillation (AF) and sinus rhythm (SR) subjects after 26 ± 8(SD) months with respect to platelet reactivity and activity.…”

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confidence: 99%

Mechanisms underlying the hypertensive response induced by capsaicin

Dutta

Deshpande

2010

International Journal of Cardiology

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“…Evidence has been also provided that the activation of the sympathetic nervous system is peculiar to the essential hypertensive state, parallels the degree of the blood pressure elevation, is triggered by reflex and humoral mechanisms, and may exert deleterious metabolic and cardiovascular effects, accelerating the progression of the end organ damage accompanying hypertension [3]. Cases of hypertensive crisis due to ingestion of capsaicin have been previously reported [7,8]. Cases of myocardial infarction due to ingestion of capsaicin have also been previously reported [8,9].…”

Section: Discussionmentioning

confidence: 99%

A case of acute myocardial infarction due to the use of cayenne pepper pills

Sayın

Karabağ

Dogan

et al. 2012

Wien Klin Wochenschr

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The use of weight loss pills containing cayenne pepper has ever been increasing. The main component of cayenne pepper pills is capsaicin. There are conflicting data about the effects of capsaicin on the cardiovascular system. In this paper, we present the case of a 41 year old male patient with no cardiovascular risk factors who took cayenne pepper pills to lose weight and developed acute myocardial infarction.

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“…Several case histories of acute hypertensive crisis provoked by very high intakes of chilli peppers have appeared; down-regulated function of CGRP-producing neurons owing to acute high capsaicin exposure has been suggested as an explanation for this effect. 37 38 On the other hand, a more moderate capsaicin exposure associated with the use of capsaicin patches—sufficient to alleviate angina pain—did not alter plasma levels of CGRP, but plasma levels of NO metabolites increased. 31 Whether and how moderate, clinically tolerable dosing with capsaicin would influence human hypertension has not yet been assessed.…”

Section: Capsaicin Can Increase Expression and Activation Of Enosmentioning

confidence: 95%

Capsaicin may have important potential for promoting vascular and metabolic health

2015

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Capsaicin, the phytochemical responsible for the spiciness of peppers, has the potential to modulate metabolism via activation of transient receptor potential vanilloid 1 (TRPV1) receptors, which are found not only on nociceptive sensory neurons, but also in a range of other tissues. TRPV1 activation induces calcium influx, and in certain tissues this is associated with increased activation or expression of key proteins such as endothelial nitric oxide synthase (eNOS), uncoupling protein 2 (UCP2), KLF2, PPARdelta, PPARgamma, and LXRα. The calcium influx triggered by TRPV1 activation in endothelial cells mimics the impact of shear stress in this regard, activating and increasing the expression of eNOS—but also increasing expression of cox-2, thrombomodulin, and nrf2-responsive antioxidant enzymes, while decreasing expression of proinflammatory proteins. Hence, dietary capsaicin has favourably impacted endothelium-dependent vasodilation in rodents. TRPV1-mediated induction of LXRα in foam cells promotes cholesterol export, antagonising plaque formation. Capsaicin-mediated activation of TRPV1-expressing neurons in the gastrointestinal tract promotes sympathetically mediated stimulation of brown fat, raising metabolic rate. The increased expression of UCP2 induced by TRPV1 activation exerts a protective antioxidant effect on the liver in non-alcoholic fatty liver disease, and on vascular endothelium in the context of hyperglycaemia. In rodent studies, capsaicin-rich diets have shown favourable effects on atherosclerosis, metabolic syndrome, diabetes, obesity, non-alcoholic fatty liver, cardiac hypertrophy, hypertension and stroke risk. Clinically, ingestion of capsaicin—or its less stable non-pungent analogue capsiate—has been shown to boost metabolic rate modestly. Topical application of capsaicin via patch was found to increase exercise time to ischaemic threshold in patients with angina. Further clinical studies with capsaicin administered in food, capsules, or via patch, are needed to establish protocols that are tolerable for most patients, and to evaluate the potential of capsaicin for promoting vascular and metabolic health.

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Capsaicin and arterial hypertensive crisis

Cited by 17 publications

References 6 publications

Mechanisms underlying the hypertensive response induced by capsaicin

Mechanisms underlying the hypertensive response induced by capsaicin

A case of acute myocardial infarction due to the use of cayenne pepper pills

Capsaicin may have important potential for promoting vascular and metabolic health

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