“…The estimation of the effect of substances on the capillary permeability by determining protein-bound dye leakage into the tissues in the deposit area was a method originally described by RAMSDELL (1928). The technique is most widely used in investigating disturbances in capillary permeability (SPECTOR 1958). The test has been used in rabbits, mice, guinea pigs, rats and even man (MENKIN 1936, MILES & MILES 1952, SPECTOR & WILLOUGHBY 1957, SPARROW & WILHELM 1957, STEWART & BLISS 1957, JUDAH & WILLOUGHBY 1962, WILHELM 1962.…”