Capillary‐permeability factors, nucleosides and histamine release

Spector, W. G.; Willoughby, D. A.

doi:10.1002/path.1700730116

Cited by 28 publications

(7 citation statements)

References 9 publications

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“…The estimation of the effect of substances on the capillary permeability by determining protein-bound dye leakage into the tissues in the deposit area was a method originally described by RAMSDELL (1928). The technique is most widely used in investigating disturbances in capillary permeability (SPECTOR 1958). The test has been used in rabbits, mice, guinea pigs, rats and even man (MENKIN 1936, MILES & MILES 1952, SPECTOR & WILLOUGHBY 1957, SPARROW & WILHELM 1957, STEWART & BLISS 1957, JUDAH & WILLOUGHBY 1962, WILHELM 1962.…”

Section: Discussionmentioning

confidence: 99%

Changes in Vascular Permeability after Local Application of Roentgen Contrast Media in the Hamster Cheek Pouch

Sørensen¹

1971

Acta Radiologica. Diagnosis

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BRANEMARK et colI. (1969) reported that all contrast media currently in use cause microcirculatory disturbances to a varying degree to the hamster's cheek pouch after their local application. Signs of damage to the endothelium were demonstrated by an increasing number of white cells adhering to the vessel wall and sometimes thrombus formation. The present investigation was therefore undertaken to find out whether these microcirculatory changes may be associated with an increase in vascular permeability. As all contrast media are hypertonic solutions special consideration was given to the possible relation between the osmolarity of the media and changes in the vascular permeability. The significance of the hypertonicity of the contrast media was also analysed in simultaneously performed vital microscopy investigations.Material and Methods. The contrast media and equimolar chloride solutions investigated appear in Table 1. The change in permeability caused by a pure

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Section: Discussionmentioning

confidence: 99%

Changes in Vascular Permeability after Local Application of Roentgen Contrast Media in the Hamster Cheek Pouch

Sørensen¹

1971

Acta Radiologica. Diagnosis

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“…The rational approach in the man agement of diffuse peritonitis is to eliminate the source of peritoneal contamination and to remove the infected debris. Removal of infected debris involves the host response comprising of antibody production, comple ment activation, cellular immunity and bac terial clearing by polymorphonuclear leuco cytes and macrophges [4,17], After an injury to the peritoneal serosa, peritoneal mast cells release histamine and other permeability factors such as nucleo sides and polypeptides [22], These substances cause an increase in vascular permeability, and a protein-rich fibrinogen-containing plasma is exuded into the peritoneal cavity [1]. Since the injured cells also release throm boplastin, fibrinogen is converted into fibrin.…”

Section: Discussionmentioning

confidence: 99%

Low-Dose Heparin in Experimental Peritonitis

Gupta

Jain

1985

Eur Surg Res

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The aim of this investigaton was to study the beneficial role of low-dose heparin in peritonitis. Peritonitis was induced in 20 dogs by the technique of Rosato and co-authors, 10 of which received low-dose heparin subcutaneously for 5 days in a dose of 100 units/kg body weight. Decreased mortality as well as decrease in the formation of intra-abdominal abscesses and adhesions were observed in the heparin-treated dogs. Some of the possible underlying mechanisms for beneficial effects of heparin in peritonitis are discussed.

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“…This subject has been extensively reviewed by Spector (1958). An embarrassingly large number of substances have been described that could produce the increase in capillary permeability which is observed in the inflammatory reaction.…”

Section: Reninmentioning

confidence: 99%

“…These recent developments eliminate the need to prepare dextran fractions of 'narrow' molecular weight distribution and enable more precise work to be done with dextran (Hardwicke, Hulme, Jones and Ricketts, 1964). Grotte Lewis (1927), Gaddum (1948), Spector and Willoughby (1957), Majno and Palade (1961).…”

mentioning

confidence: 99%

Capillary Permeability to Plasma Proteins

1965

Postgraduate Medical Journal

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Capillary‐permeability factors, nucleosides and histamine release

Cited by 28 publications

References 9 publications

Changes in Vascular Permeability after Local Application of Roentgen Contrast Media in the Hamster Cheek Pouch

Changes in Vascular Permeability after Local Application of Roentgen Contrast Media in the Hamster Cheek Pouch

Low-Dose Heparin in Experimental Peritonitis

Capillary Permeability to Plasma Proteins

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