BRANEMARK et colI. (1969) reported that all contrast media currently in use cause microcirculatory disturbances to a varying degree to the hamster's cheek pouch after their local application. Signs of damage to the endothelium were demonstrated by an increasing number of white cells adhering to the vessel wall and sometimes thrombus formation. The present investigation was therefore undertaken to find out whether these microcirculatory changes may be associated with an increase in vascular permeability. As all contrast media are hypertonic solutions special consideration was given to the possible relation between the osmolarity of the media and changes in the vascular permeability. The significance of the hypertonicity of the contrast media was also analysed in simultaneously performed vital microscopy investigations.Material and Methods. The contrast media and equimolar chloride solutions investigated appear in Table 1. The change in permeability caused by a pure
A phlebographic study in 32 children has shown that i.v. infusion of invertose, glucose, Vamine and Intralipid but not saline, damages the tissues as judged from changes in the vessel walls, oedema and disturbances in the venous circulation. The addition of Heparin to the solutions markedly reduced the frequency of these untoward reactions. The toxicity of invertose, glucose, Vamine and Intralipid was studied experimentally in a biologic tissue: the cheek pouch of the hamster. All solutions particularly Vamine caused some damage to the microcirculation. In this study the factor mainly responsible for thrombophlebitis was the toxicity of the solution infused. Other factors such as surgical trauma, site of entry, local infection, temperature of solutions etc. played only a minor role.
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