Cantalanin-A, A New Saponin From the Leaves of Agave cantala

Varshney, I. P.; Jain, D. C.; Srivastava, H. C.

doi:10.1021/np50018a005

Cited by 11 publications

(3 citation statements)

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“…Many species from Agave genus have been extensively investigated in chemical constituents, such as A. ghiesbrechtii (Blunden et al, 1974), A. cantala (Varshney et al, 1981(Varshney et al, , 1982Sharma and Sati, 1982;Pant et al, 1986;Sati et al, 1985Sati et al, , 1987Jain, 1987;Uniyal et al, 1990Uniyal et al, , 1991a, A. sisalana (Blunden et al, 1986;Ding et al, 1989Ding et al, , 1993Zou et al, 2006;Chen et al, 2009Chen et al, , 2011, A. utahensis Mimaki, 2007, 2009), A. shrevei (Pereira da Silva et al, 2006a), A. americana (Jin et al, 2002a(Jin et al, ,b, 2003b(Jin et al, , 2004Jin and Yang, 2003a;Yokosuka et al, 2000;Tinto et al, 2005), A. fourcroydes (Ohtsuki et al, 2004), A. attenuata Salm-Dyck (Paz Mendes et al, 2004;Pereira da Silva et al, 2002), A. macroacantha Zucc (Eskander et al, 2010), A. dicipiens Baker (Abdel Gawad et al, 1999), A. brittoniana Trel. Spp Brachypus (Macías et al, 2007(Macías et al, , 2010, A. barbadensis (Tinto et al, 2005) and A. tequilana Weber (Morales Serna et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Bioactive steroidal saponins from Agave offoyana flowers

et al. 2013

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Bioguided studies of flowers of Agave offoyana allowed the isolation of five steroidal saponins never described previously, Magueyosides A-E (1-5), along with six known steroidal saponins (6-11). The structures of compounds were determined as (25R)-spirost-5-en-2α,3β-diol-12-one 3-O-{β-d-xylopyranosyl-(1→3)-O-β-d-glucopyranosyl-(1→2)-O-[β-d-xylopyranosyl-(1→3)]-O-β-d-glucopyranosyl-(1→4)-O-β-d-galactopyranoside} (1), (25R)-spirost-5-en-2α,3β-diol-12-one 3-O-{β-d-glucopyranosyl-(1→2)-O-[β-d-xylopyranosyl-(1→3)]-O-β-d-glucopyranosyl-(1→4)-O-β-d-galactopyranoside} (2), (25R)-spirost-5-en-2α,3β,12β-triol 3-O-{β-d-glucopyranosyl-(1→2)-O-[β-d-xylopyranosyl-(1→3)]-O-β-d-glucopyranosyl-(1→4)-O-β-d-galactopyranoside} (3), (25R)-5α-spirostan-2α,3β-diol-12-one 3-O-{β-d-xylopyranosyl-(1→3)-O-β-d-glucopyranosyl-(1→2)-O-[β-d-xylopyranosyl-(1→3)]-O-β-d-glucopyranosyl-(1→4)-O-β-d-galactopyranoside} (4), and (25R)-5α-spirostan-2α,3β-diol-9(11)-en-12-one 3-O-{β-d-xylopyranosyl-(1→3)-O-β-d-glucopyranosyl-(1→2)-O-[β-d-xylopyranosyl-(1→3)]-O-β-d-glucopyranosyl-(1→4)-O-β-d-galactopyranoside} (5), by comprehensive spectroscopic analysis, including one- and two-dimensional NMR techniques, mass spectrometry and chemical methods. The bioactivities of the isolated compounds on the standard target species Lactuca sativa were evaluated. A dose-dependent phytotoxicity and low dose stimulation were observed.

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Section: Introductionmentioning

confidence: 99%

Bioactive steroidal saponins from Agave offoyana flowers

et al. 2013

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“…The leaves of A. shrevei yielded 5, which inhibited capillary permeability activity (IC 50 = 55 mg/kg for each animal), a typical response that occurs in the first stage of an inflammatory reaction [13]. The chemical investigation of A. cantala yielded the agavesides A-D (8-11) [14][15][16], 13 and 14 [17][18], the cantalasaponins-1 to 4 (15-18) [19][20][21], 19, 21 and cantalanin-A ( 22) [10,[22][23]. Hydrolysis of agaveside C (10) with β-glucosidase afforded 12 [15], while methylation of 19 afforded the methyl ether 20 [22].…”

Section: Agavementioning

confidence: 99%

Steroidal Saponins and Sapogenins from the Agavaceae Family

Simmons-Boyce

Tinto

2007

Natural Product Communications

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Plants belonging to the family Agavaceae are used in folkloric medicinal practices worldwide and chemical investigations of these plants have shown that they are an abundant source of steroidal saponins and sapogenins. Despite the large number of secondary metabolites isolated from this family so far, there have been few reports on the bioactivity of these compounds. This article provides a comprehensive review of the steroidal constituents of plants from the genera Agave, Cordyline, Dracaena, Furcraea, Nolina, Sansevieria and Yucca up to June 2006, and reports on the bioactivity of these compounds where available.

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“…reputation in the Indian system of medicine (1) and have recently been reported to exhibit anticancer activity (2). Different spirostanol glycosides have been reported (3)(4)(5) from the leaves and rhizomes, and a hecogenin-based triglucoside has been characterized (6) from the fruits of Agave cantala Roxb.…”

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confidence: 99%