Our investigations into the stability of tincture preparations of milk thistle fruit [ Silybum marianum L. Gaertn. (Asteraceae)] have led to the characterization of a new flavonolignan 4-(4-hydroxy-3-methoxyphenyl)-7-[(2 R,3 R)-3,5,7-trihydroxy-4-oxochroman-2-yl]-1-oxo-1,3,3a,4,5,7a-hexahydro-2-benzofuran-5-carboxylic acid called silyamandin (1). Incubation of the tincture at 40 degrees C for 3 months resulted in an increase in the level of this compound, as observed in the LC/DAD silymarin profile.
Plants belonging to the family Agavaceae are used in folkloric medicinal practices worldwide and chemical investigations of these plants have shown that they are an abundant source of steroidal saponins and sapogenins. Despite the large number of secondary metabolites isolated from this family so far, there have been few reports on the bioactivity of these compounds. This article provides a comprehensive review of the steroidal constituents of plants from the genera Agave, Cordyline, Dracaena, Furcraea, Nolina, Sansevieria and Yucca up to June 2006, and reports on the bioactivity of these compounds where available.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.