Steroidal Saponins and Sapogenins from the Agavaceae Family

Abstract

Plants belonging to the family Agavaceae are used in folkloric medicinal practices worldwide and chemical investigations of these plants have shown that they are an abundant source of steroidal saponins and sapogenins. Despite the large number of secondary metabolites isolated from this family so far, there have been few reports on the bioactivity of these compounds. This article provides a comprehensive review of the steroidal constituents of plants from the genera Agave, Cordyline, Dracaena, Furcraea, Nolina, Sansevieria and Yucca up to June 2006, and reports on the bioactivity of these compounds where available.

Characterization of antioxidant properties and metabolite profile of Agave atrovirens extracts

“…Caco-2 cells [19]. Additionally, several authors have described that saponins from different sources are also NRF2 activators [20][21][22] and Agave plants are important sources of saponins and the occurrence of steroidal saponins is well documented [23,24]. On the other hand, it is worthy to mention that cytotoxic properties have been described for agave saponins [7,25].…”

Structures and Bioactivities of Steroidal Saponins Isolated from the Genera Dracaena and Sansevieria

“…The structures and bioactivities of phenolic constituents, flavonoids and stilbenoids have been reported in recent reviews [ 8 , 22 ]. On the other hand, there is great interest in saponins due to their intriguing structures and the potent analgesic, anti-inflammatory, antimicrobial, antioxidant, antiproliferative, hypocholesterolemic, and cytotoxic activities [ 23 , 24 , 25 ]. This paper describes the about 180 different saponins isolated from 14 Dracaena and 3 Sansevieria species that have been investigated so far for these metabolites.…”

“…The literature has been retrieved from the databases Reaxys ® , Scifinder ® , and Google Scholar until the end 2020. A partial list of saponins isolated from Dracaena and Sansevieria species has been included in an earlier review on the Agavaceae family [ 23 ].…”

Isolamento de compostos fenólicos a partir do resíduo de Agave sisalana Perrine (sisal) e atividade anticolinesterásica

“…Muitas espécies de Agave apresentam diversas aplicações comerciais, desde fornecedoras de fibras duras e bebidas alcoólicas, à fonte de matéria-prima esteroidal para indústria farmacêutica (DING et al, 1993;PEÑA-ALVAREZ et al, 2004). Do ponto de vista biosintético, este gênero produz compostos fenólicos, hidrocarbonetos, esteróides, sacarídeos e saponinas (SIMMONS-BOYCE;TINTO, 2007;CHEN et al, 2009). Entre estas espécies, Agave sisalana Perrine se destaca pelo fornecimento de fibras duras, sendo o Brasil responsável por mais de 50 % da produção mundial de sisal.…”