Cannabidiol—transdermal delivery and anti-inflammatory effect in a murine model

Lodzki, M.; Godin, Biana; Rakou, L.; Mechoulam, Raphael; Gallily, Ruth; Touítou, Elka

doi:10.1016/j.jconrel.2003.09.001

Cited by 213 publications

(112 citation statements)

References 20 publications

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“…[2][3][4][5][6] vesicular formulations have demonstrated an impressive ability to enhance the permeability of RA drugs. 13 Studies have previously reported that liposomal encapsulation of RA drugs may improve drug accumulation in inflamed synovial tissue, but conventional liposomes often suffer from the shortcomings of instability, low encapsulation efficiency (EE), and limited drug delivery efficiency. 14 Ethosomes are a novel type of liposomes containing a high concentration of shortchain alcohols, including ethanol, propylene glycol, or even a mixture of ethanol and propylene glycol.…”

Section: Introductionmentioning

confidence: 99%

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Zhang

et al. 2017

IJN

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In this study, a novel glycerosome carrier containing essential oils was prepared for topical administration of paeoniflorin (PF) to enhance its transdermal drug delivery and improve drug absorption in the synovium. The formulation of glycerosomes was optimized by a uniform design, and the final vehicle was composed of 5% (w/v) phospholipid, 0.6% (w/v) cholesterol, and 10% (v/v) glycerol, with 2% (v/v) Speranskia tuberculata essential oil (STO) as the transdermal enhancer. The in vitro transdermal flux of PF loaded in the STO-glycerosomes was 1.4-fold, 1.6-fold, and 1.7-fold higher than those of glycerosomes, liposomes, and tinctures, respectively. In vivo studies showed that the use of STO-glycerosomes was associated with a 3.1-fold greater accumulation of PF in the synovium than that of common glycerosomes. This finding was confirmed by in vivo imaging studies, which found that the fluorescence intensity of Cy5.5-loaded STO-glycerosomes in mice knee joints was 1.8-fold higher than that of the common glycerosomes 5 h after administration. The glycerosomes mediated by STO exhibited considerable skin permeability as well as improved drug absorption in the synovium, indicating that STO-glycerosomes may be a potential PF transdermal delivery vehicle for the treatment of rheumatoid arthritis caused by synovium lesions.

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Section: Introductionmentioning

confidence: 99%

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Zhang

et al. 2017

IJN

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“…There was no significant difference in vesicle size of empty and capsaicin-loaded ethosomes with acceptable uniformity index and other physical characterization parameter. Viscosity of drug ethosomes was less than empty vesicle, indicating enhancement of flexibility by synergistic effect of ethanol as well as capsaicin on the lipid membrane, composed of phospholipid (Lodzki et al, 2003). On the other hand, both ethanol and capsaicin may also affect the fluidity of epidermis lipid; it would induce membrane fluidization effect which further enhances the drug Ethosomal capsaicin, despite better results, is statistically significant compared to control group (p50.001).…”

Section: Discussionmentioning

confidence: 94%

Topical ethosomal capsaicin attenuates edema and nociception in arthritic rats

2014

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In this study, topical ethosomal formulation of capsaicin was prepared and evaluated for bioefficacy in arthritic rats. Physical and biological characterizations of prepared capsaicin-loaded nano vesicular systems were also carried out. Ethosomal capsaicin showed significant reduction of rat paw edema along with promising antinociceptive action. The topical antiarthritic efficacy of prepared formulation of capsaicin was found more than that of Thermagel, a marketed gel of capsaicin. From toxicological study, no predictable signs of toxicity such as skin irritation (of experimental rats) were observed. Based on this finding, ethosomal capsaicin could be proposed as an effective as well as a safe topical delivery system for the long-term treatment of arthritis and associated inflammo-musculoskeletal disorders. Such exciting result would eventually enlighten the analgesic and anti-inflammatory potential of capsaicin for topical remedy.

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“…Moreover, the anti-inflammatory activity was also higher from ethosomes. Lodzki et al [63] and Touitou et al, developed cannabidiol loaded ethosomes for transdermal delivery. They reported that 49% of the loaded (845 g/cm 2 ) accumulated in within the viable skin tissue over 24-h period.…”

Section: Phospholipidsmentioning

confidence: 99%

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Madhavi

2016

AJP

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Aim: The aim of the present work was to focus on the applicability of liposomes and ethosomes for transdermal delivery. In the current review, we had focused on transdermal delivery transdermal delivery of vesicular system vesicular systems, i.e., liposome and ethosomes, factors affecting their permeation and penetration efficiency, limitations, applications, method of preparations, evaluation parameters, and selection of lipids. In this review, we considered the mechanism of controlled drug release of vesicles by transdermal delivery and the impact of their physicochemical properties. Rheumatoid arthritis (RA) is most frequently suffering disease in the geriatric population. By transdermal delivery, conventional anti-RA (ARA) therapy associated with several disadvantages. The modern ARA therapy; disease-modifying antirheumatic drugs (DMARDs) are more effective in reducing down disease progression. The basic mechanism of action of DMARDs in RA is not clear. The vesicles have a potential role in RA; especially, we focused on the impact of liposomes and ethosomes on RA by transdermal delivery, vesicular mechanism to justification in ARA therapy. Conclusion: The liposomes and ethosomes were beneficial tools for transdermal delivery. They have a potential role to control RA by transdermal delivery.

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Cannabidiol—transdermal delivery and anti-inflammatory effect in a murine model

Cited by 213 publications

References 20 publications

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Topical ethosomal capsaicin attenuates edema and nociception in arthritic rats

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