Canine Testicular Tumours: a Study on 232 Dogs

Grieco, Valeria; Riccardi, Elena; Greppi, G.F.; Teruzzi, F.; Iermanò, V.; Finazzi, M.

doi:10.1016/j.jcpa.2007.11.002

Cited by 97 publications

(96 citation statements)

References 14 publications

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“…The fact that the Leydig cell tumours showed a strong expression of the von Willebrand factor, a marker of vascular endothelial cells (5,14,20), suggests that these neoplasms may show an enhanced angiogenesis. This seems to be consistent with frequent macroscopic evidence of haemorrhagic foci in these tumours, and point to the presence of structural abnormalities in the tumour vessels (6). The expression of the von Willebrand factor in the remaining neoplasms was weaker than in the Leydig cell tumours.…”

Section: Resultssupporting

confidence: 81%

Expression of Selected Markers in Immunohistochemical Diagnosis of Canine and Human Testicular Tumours

Ciaputa

Nowak

Madej

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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Immunohistochemical profiles of the most common canine testicular tumours, including the Leydig cell tumours, seminomas, and Sertoli cell tumours were analysed, and the results were compared with those obtained in the corresponding types of human testicular neoplasms. The expressions of vimentin, von Willebrand factor (FVIII), chromogranin A, synaptophysin, and MCM3 were quantified. In the case of Sertoli cell tumours, only canine ones were analysed, since this type of tumour is very rarely diagnosed in men. The expression of the analysed proteins in the testicular tumours was similar. The von Willebrand factor exhibited the strongest expression in Leydig cell tumours in dogs and men, while vimentin was expressed more strongly in dogs (96.7% had an intensity at +++) than in men (62.5% had +++) in the Leydigioma. The immunoexpression of MCM3 in seminomas was high in both men and dogs -90% +++ and 100% +++ respectively. The lack of chromogranin A and synaptophysin was observed in almost 100% of seminomas in men and dogs. This differed from the results obtained for Leydigioma, where chromogranin A was expressed in 70% of dogs at +++ and in 100% of men at ++++. The results may indicate that the antibodies were selected correctly. Their analysis and interpretation provides valuable information concerning the nature of the studied tumours.

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Section: Resultssupporting

confidence: 81%

Expression of Selected Markers in Immunohistochemical Diagnosis of Canine and Human Testicular Tumours

Ciaputa

Nowak

Madej

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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“…Interestingly, most of SEMs and SCTs were specified before the age of 10 years old, while over 60% of ICTs were identified in the older ages with tumor appearance. In addition, ICTs were the most common tumors (> 50%) identified in clinically normal testes (no signs of testicular tumor, feminization, or cryptorchidism) in the earlier reports [2,10]. This implies that the tumorigenesis of ICTs may appear more slowly than other tumor types, and will therefore not be identified until tumors have grown large enough to draw attention during older age.…”

Section: Discussionmentioning

confidence: 97%

“…Mixed germ cell-sex stromal cell tumors (MGCSCTs; two or more different tumor types from germ cell or sex cord stromal cell in one testis) consist of intimately associated germ cells and Sertoli cells, but not interstitial cells [12,19]. However, a previous study on 110 tumors from 62 tumor-affected dogs demonstrated that ICTs and SEMs share equally over 90% of testicular tumors and the prevalence of SCTs is extremely low (8%) [2]. It is rarely reported that testicular tumors arising from other cell lineages and giving raise to tumors, including hemangiomas, granulose cell tumors, teratomas, sarcomas, embryonal carcinomas, gonadoblastomas, lymphomas, and rete testis mucinous adenocarcinomas [12,15,19].…”

mentioning

confidence: 99%

“…Another study demonstrated that cryptorchid dogs older than 10 years were more likely to develop tumors than younger dogs under 6 years [17]. Certain breeds seemed to have an increased risk of developing primary testicular tumors, including the Boxer, German Shepherd, Afghan Hound, Weimaraner, and Shetland Sheepdog [2,10,14,16,21]. Epidemiological studies on military working dogs serving in the Vietnam War implied that exposure to phenoxy herbicide, dioxin, or tetracycline may have promoted the development of testicular tumors [4,5].…”

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confidence: 99%

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A 12-Year Retrospective Study of Canine Testicular Tumors

et al. 2009

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ABSTRACT. To provide up-to-date information on the incidence and risk factors of canine testicular tumors, 476 pathological reports of male canine tumors from two institutes of veterinary medicine in Taiwan Cryptorchidism was significantly associated with development of MGCSCTs, SCTs, and SEMs, but not ICTs (p<0.01). The detection rate of testicular tumors in the dog younger than 10-years-old was significantly associated with cryptorchidism (p<0.01). Except for mixed breed dogs, the Maltese breed had high detection rate of testicular tumors, and may have high risk in cryptorchidism in this study.In conclusion, our results indicate that cryptorchidism alone or in addition to age will significantly affect the incidence and type of canine testicular tumors, and a high detection rate of testicular tumors in Maltese dogs is documented for the first time.

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“…These represent the third most common neoplasm of canine testes, after interstitial cell tumours and seminomas (Grieco et al 2008). The usual clinical course is a solitary, benign mass; metastatic tumours occur in less than 10% of cases.…”

mentioning

confidence: 99%