Hyperoestrogenism and mammary adenosis associated with a metastatic Sertoli cell tumour in a male Pekingese dog

Warland, James; Constantino‐Casas, Fernando; Dobson, J. M.

doi:10.1080/01652176.2011.653593

Cited by 6 publications

(13 citation statements)

References 14 publications

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“…Some animals suffer from pyrexia, as happened in this case. This is mostly due to secondary infections, for example of the urinary tract, due to the presence of neutropenia (Dhaliwal et al, 1999;Sanpera et al, 2002;Kim and Kim, 2005;Plavec et al, 2007;De Bosschere and Deprest, 2010;Hong et al, 2011;Kang et al, 2011;Warland et al, 2011;Carreira et al, 2012;Herndon et al, 2012;Quartuccio et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Myelotoxicosis occurs in 15% of the individuals with Sertoli cell tumors (Sanpera et al, 2002). Most of the time a moderate non-regener- ative anemia, leukopenia, neutropenia and/or severe thrombocytopenia are detected (Sanpera et al, 2002;Plavec et al, 2007;Warland et al, 2011;Quartuccio et al, 2012). In cases of testicular neoplasia presenting with signs of myelotoxicosis, it is therefore useful to determine the concentration of circulating estrogens (estradiol 17β), which is often elevated.…”

Section: Discussionmentioning

confidence: 99%

“…In cases of testicular neoplasia presenting with signs of myelotoxicosis, it is therefore useful to determine the concentration of circulating estrogens (estradiol 17β), which is often elevated. Many, but not all, of these dogs also show external symptoms of feminization (Sanpera et al, 2002;Plavec et al, 2007;Warland et al, 2011;Quartuccio et al, 2012). De Bosschere and Deprest (2010) reported a case of a nine-year-old Beauceron with estrogen-induced pancytopenia without obvious clinical signs related to feminization.…”

Section: Discussionmentioning

confidence: 99%

“…Abdominal radiographs were not performed in this case, because ultrasonography was available and is considered to be more sensitive in the detection of neoplastic cryptorchid testicles and abdominal metastases. Sometimes, fine needle aspirates are taken from the abdominal mass, mostly to confirm its neoplastic origin (Dhaliwal et al, 1999;Barrand and Scudamore, 2001;Sanpera et al, 2002;Kim and Kim, 2005;De Bosschere and Deprest, 2010;Hong et al, 2011;Warland et al, 2011;Lawrence and Saba , 2013).…”

Section: Discussionmentioning

confidence: 99%

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Feminisatie en ernstige pancytopenie veroorzaakt door testiculaire neoplasie in een cryptorche hond

Paepe¹,

Hebbelinck²,

Kitshoff³

et al. 2016

Vlaams Diergeneeskundig Tijdschrift

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In this case report, a paraneoplastic syndrome caused by testicular neoplasia in a ten-year-old cryptorchid dog is described. Feminization and pancytopenia were observed, resulting from the testicular neoplastic production of estrogens. A diagnosis of testicular tumor and associated bone marrow suppression was made by ultrasonography and blood examination, with estrogen blood levels being severely elevated. Urinalysis revealed a urinary tract infection. Castration was performed together with a blood transfusion, and antibiotic treatment was started. After an initial improvement, the dog died suddenly after approximately three weeks. In this report, the importance is highlighted of identifying clinical signs associated with feminization in intact male dogs at an early stage, to avoid severe, potentially irreversible, hematological consequences due to bone marrow suppression. Elective orchidectomy of both testes is highly recommended in cryptorchid dogs as neoplastic transformation of the undescended testis may occur, with potentially fatal outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Feminisatie en ernstige pancytopenie veroorzaakt door testiculaire neoplasie in een cryptorche hond

Paepe¹,

Hebbelinck²,

Kitshoff³

et al. 2016

Vlaams Diergeneeskundig Tijdschrift

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“…8 A paraneoplastic feminization syndrome secondary to hyperestrogenism results, characterized by clinical signs which may include non-pruritic, bilateral symmetrical alopecia, hyperpigmentation, gynecomastia, prostatomegaly and preputial edemae. [7][8][9][10] A more serious concern with hypersecretion of oestrogen is myelotoxicity that can occur secondary to this paraneoplastic syndrome. Myelotoxicity can occur in up to 15% of dogs with Sertoli cell tumours and cause reversible or irreversible bone marrow hypoplasia resulting in pancytopenia and non-regenerative anaemia.…”

mentioning

confidence: 99%

Outcome of dogs with bone marrow suppression secondary to Sertoli cell tumour

Salyer

Lapsley

Palm

et al. 2021

Vet Comparative Oncology

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Sertoli cell tumours are one of the most common canine testicular neoplasia. These tumours are significantly more likely to arise in cryptorchid dogs and are often functional, oestrogen‐secreting tumours which can lead to fatal myelotoxicity. The goal of this study was to describe the outcome of dogs with oestrogen‐induced bone marrow suppression secondary to Sertoli cell tumours in seven client‐owned dogs. Medical records from April 1, 2011 through April 1, 2021 were reviewed to identify dogs that underwent surgical management of a Sertoli cell tumour with documented bone marrow suppression. Overall, 5/7 dogs required transfusion of blood products peri‐operatively. Cases 1 and 6 received a transfusion of packed red blood cells (RBC) prior to surgery and case 5 required a transfusion of whole blood. Case 1 also required a transfusion of platelets before surgery. Post‐operatively, cases 1 and 2 received packed RBC's and case 6 received two transfusions of whole blood. Case 3 required transfusions of both fresh frozen plasma and platelets post‐operatively. All dogs survived to discharge and 6/7 dogs had documented improvement in haematopoietic values. Two dogs remained chronically thrombocytopenic. The median hospital stay was 4 days. One dog died within 4 weeks of surgery from worsening pancytopenia. Survival for greater than 1 year was documented in 4/7 dogs, and one dog was lost to follow‐up 4 months post‐operatively. One dog remained severely pancytopenic 4 weeks post‐operatively and received oral lithium treatment. Improvements in all blood cell lines were observed within the 4 weeks and resolution of pancytopenia within 6 weeks. Historically, the prognosis for dogs with bone marrow suppression secondary to Sertoli cell tumours was guarded to poor. This report documented improved outcomes for dogs that underwent surgery, including one dog that received lithium chloride as treatment for Sertoli cell tumour‐induced bone marrow suppression.

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Occurrence of mammary gland tumours in male dogs and its weak association with development of testicular tumours: a review

Tkaczyk-Wlizło,

Kowal,

Śmiech

et al. 2023

J Appl Genetics

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Mammary gland tumours (MGTs) are commonly occurring neoplasms in female dogs. However, rare cases of MGTs in male dogs have been reported for years. Due to the low incidence of MGTs in male dogs in comparison to female dogs, veterinary oncology is mainly focused on mammary neoplasms diagnosed in female dogs and extensive research is conducted in this scientific area. Therefore, there are no sufficient epidemiological data on male dogs and the aetiology of their tumour development is still poorly understood.The aim of this literature review was to present cases of MGTs in male dogs for better understanding the scale of the problem over the years. The analyses of 74 affected male dogs with 92 tumours showed that the majority of MGTs in male dogs were benign tumours (54.3%), especially in form of adenomas, often developed in posterior canine mammary glands (58.1%).The increased number of canine MGTs in male dogs aged 7 -13 years with an age peak at 11 years was noted. The age of affected animals was not related to breed. Mammary gland neoplasms were diagnosed predominately in Crossbreeds (20.2%) followed by Cocker Spaniels (18.9%) and German Shepherds (10.8%).The association between MGT development in male dogs and co-occurrence of testicular tumours (TTs) has been discussed for years. Thus, cases of development of both tumours were included in this study. As a result, only in 12.7% cases of MGTs also history of TTs was described. Therefore, no general association between these tumours should be assumed.

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Hyperoestrogenism and mammary adenosis associated with a metastatic Sertoli cell tumour in a male Pekingese dog

Cited by 6 publications

References 14 publications

Feminisatie en ernstige pancytopenie veroorzaakt door testiculaire neoplasie in een cryptorche hond

Feminisatie en ernstige pancytopenie veroorzaakt door testiculaire neoplasie in een cryptorche hond

Outcome of dogs with bone marrow suppression secondary to Sertoli cell tumour

Occurrence of mammary gland tumours in male dogs and its weak association with development of testicular tumours: a review

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