Canine scent detection of human cancers: A review of methods and accuracy

Moser, E. Barry; McCulloch, Michael

doi:10.1016/j.jveb.2010.01.002

Cited by 101 publications

(76 citation statements)

References 13 publications

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“…The outstanding sensitivity of the canine olfactory system has been acknowledged by using sniffer dogs in military and civilian Inter-ratervariability k 0.436 service for detection of a variety of odours. Moreover, sniffer dogs have been employed in pre-clinical studies for cancer diagnosis [22,23]. In 2006, MCCULLOCH et al [14] reported a sensitivity and specificity of 99% for sniffer dogs to diagnose lung cancer from patients' breath samples.…”

Section: Discussionmentioning

confidence: 99%

Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon

Ehmann

Boedeker²,

Friedrich³

et al. 2011

European Respiratory Journal

182

144

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Patient prognosis in lung cancer largely depends on early diagnosis. The exhaled breath of patients may represent the ideal specimen for future lung cancer screening. However, the clinical applicability of current diagnostic sensor technologies based on signal pattern analysis remains incalculable due to their inability to identify a clear target. To test the robustness of the presence of a so far unknown volatile organic compound in the breath of patients with lung cancer, sniffer dogs were applied.Exhalation samples of 220 volunteers (healthy individuals, confirmed lung cancer or chronic obstructive pulmonary disease (COPD)) were presented to sniffer dogs following a rigid scientific protocol. Patient history, drug administration and clinicopathological data were analysed to identify potential bias or confounders.Lung cancer was identified with an overall sensitivity of 71% and a specificity of 93%. Lung cancer detection was independent from COPD and the presence of tobacco smoke and food odours. Logistic regression identified two drugs as potential confounders.It must be assumed that a robust and specific volatile organic compound (or pattern) is present in the breath of patients with lung cancer. Additional research efforts are required to overcome the current technical limitations of electronic sensor technologies to engineer a clinically applicable screening tool.

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Section: Discussionmentioning

confidence: 99%

Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon

Ehmann

Boedeker²,

Friedrich³

et al. 2011

European Respiratory Journal

182

144

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show abstract

“…Olfactory analysis, either in-vivo or by organoleptic analysis of chromatographic eluents [27], combined with analytical measurement have established levels of odour to correlate with VSCs and VFAs, with 3-methyl-2-hexenoic acid cited as a critical molecular factor [26][27][28]. Finally, the quantity of anecdotal evidence of canine olfaction of disease, increasingly supported by scientific studies [29][30][31][32], reinforces the proposition of non-invasive skin VOC profiling for diagnosis and condition monitoring.…”

Section: Introductionmentioning

confidence: 93%

High throughput volatile fatty acid skin metabolite profiling by thermal desorption secondary electrospray ionisation mass spectrometry

Martin

Reynolds

Riazanskaia

et al. 2014

Analyst

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“…The use of unusual body smell (odor sensation/human olfaction) to diagnose diseases was practiced by ancient physicians (1,31). In recent years, several reports have documented that dogs can be trained to detect various types of cancers based on cancerspecific odors (volatiles) from a patient's urine, tumor tissue, or breath (56). Furthermore, African giant pouched rats have been shown to detect Mycobacterium tuberculosis-positive sputum samples (57).…”

Section: Vocs and Diagnosis Of Infectious Diseasesmentioning

confidence: 99%

Clinical Application of Volatile Organic Compound Analysis for Detecting Infectious Diseases

2013

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SUMMARY This review article introduces the significance of testing of volatile organic compounds (VOCs) in clinical samples and summarizes important features of some of the technologies. Compared to other human diseases such as cancer, studies on VOC analysis in cases of infectious diseases are limited. Here, we have described results of studies which have used some of the appropriate technologies to evaluate VOC biomarkers and biomarker profiles associated with infections. The publications reviewed include important infections of the respiratory tract, gastrointestinal tract, urinary tract, and nasal cavity. The results highlight the use of VOC biomarker profiles resulting from certain infectious diseases in discriminating between infected and healthy subjects. Infection-related VOC profiles measured in exhaled breath as well as from headspaces of feces or urine samples are a source of information with respect to disease detection. The volatiles emitted in clinical matrices may on the one hand represent metabolites of the infecting pathogen or on the other hand reflect pathogen-induced host responses or, indeed, a combination of both. Because exhaled-breath samples are easy to collect and online instruments are commercially available, VOC analysis in exhaled breath appears to be a promising tool for noninvasive detection and monitoring of infectious diseases.

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Canine scent detection of human cancers: A review of methods and accuracy

Cited by 101 publications

References 13 publications

Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon

Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon

High throughput volatile fatty acid skin metabolite profiling by thermal desorption secondary electrospray ionisation mass spectrometry

Clinical Application of Volatile Organic Compound Analysis for Detecting Infectious Diseases

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