Canine pyoderma gangrenosum: a case series of two dogs

Abstract

Pyoderma gangrenosum is a rare disease distinguished by rapid progression of painful, necrolytic, cutaneous ulcers with irregular, violaceous undermined borders. Azathioprine with glucocorticoids may lead to a better outcome than ciclosporin and glucocorticoids (currently the first-line treatment in humans and the only reported treatment in dogs).

Canine pyoderma gangrenosum with recurring skin lesions of unknown origin and splenic involvement

“…A repeat skin biopsy was not performed at the time of relapse, so the observed skin lesion was presumed to be due to PG. Evidence to support this includes marked similar appearance, rapid remission with re‐institution of high‐dose ciclosporin therapy and multiple violaceous plaques being reported at the start of ciclosporin monotherapy in a previously reported case of canine PG (plaques were erythematous in the present case) …”

“…Evidence to support this includes marked similar appearance, rapid remission with re-institution of highdose ciclosporin therapy and multiple violaceous plaques being reported at the start of ciclosporin monotherapy in a previously reported case of canine PG (plaques were erythematous in the present case). 5 Clinical insights of internal organ involvement in canine PG are very limited. This case report would suggest that veterinarians should consider screening for internal organ involvement in the management of canine PG.…”

“…After ruling out other causes of cutaneous ulceration and applying the diagnostic criteria for human pyoderma gangrenosum (PG) and criteria used in another case of canine PG, a presumptive diagnosis of PG was made. The dog was treated with prednisolone 1.5 mg/kg twice daily p.o.…”

Een atypisch geval van pyoderma gangrenosum bij een hond

“…ulcerative, pustular, bullous and vegetative (Weedon, 2002;Ruocco et al,2009). There is still little information available regarding the characteristics of PG in dogs as only a few cases have been reported in the peer-reviewed literature (Bardagi et al, 2007;Simpson et al, 2013;Declercq, 2015;Nagata et al, 2016). Affected dogs may be febrile and have malaise (Gross et al, 2005).…”

“…The phenomenon of pathergy or Koebner phenomenon, i.e. new lesions forming in response to minor trauma (Simpson et al,2013;Nagata et al, 2016) and the clinical finding of cribriform scarring (Simpson et al, 2013), minor human diagnostic criteria, have been documented. Reported effective treatments in the dog include oral prednisolone alone (Declercq, 2015;Nagata et al, 2016) or in conjunction with ciclosporin (Bardagi et al, 2007) or with azathioprine (Simpson et al,2013).…”