Canine pyoderma gangrenosum with recurring skin lesions of unknown origin and splenic involvement

Abstract

Background Reports of canine pyoderma gangrenosum (PG) are uncommon in the veterinary literature. Rarer still are cases describing dogs with both skin lesions and internal organ involvement. Objective To describe a case of canine PG with skin and internal organ involvement. Animals A client‐owned dog. Methods and materials Complete blood count, serum chemistry, C‐reactive protein and SNAP cPL tests, and abdominal ultrasonography and fine‐needle aspiration of the spleen were performed. Results The dog was treated with oral prednisolone and ciclosporin. After three months of therapy, ultrasonography revealed normalization of the spleen and resolution of skin lesions. Conclusion and clinical importance Dogs with skin lesions compatible with PG should be screened carefully for internal organ involvement. Ciclosporin may be a useful treatment for the immediate and long‐term management of canine PG.

Ulcerative neutrophilic dermatitis resembling human bromoderma in a dog

“…The findings in this case pointed to a disorder of the "sterile neutrophilic dermatoses" group, the main clinical forms of which are PG and sterile neutrophilic dermatitis resembling human Sweet's syndrome. Unlike the case with PG (Kang et al 2019;Simpson et al 2013), no improvement was observed here following the use of glucocorticoids.…”

“…Unlike the case with PG (Kang et al . 2019; Simpson et al . 2013), no improvement was observed here following the use of glucocorticoids.…”

Extensive fatal Pyoderma gangrenosum in a dog after drug exposure

“…A likely reason for the unfavorable outcome is the wide distribution of the lesions with an estimated 30 % of the body surface aff ected by deep ulcerations and the involvement of other organ systems. Most of the cases described did not seem to be that severe, except the one reported by Kang et al [ 7 ] with multifocal painful ulcers all over the body. An important factor in the prognosis of such a severe case could be the timing of initiation of immunosuppressive therapy.…”

“…Dogs may be pyretic and systemically ill, presenting with lethargy and anorexia. Gastrointestinal signs [ 7 ] and sneezing, bubble blowing and nasal stridor due to mucosal involvement have also been described [ 3 ] . Therefore, neither the pathogenesis in dogs is known, nor is there a classifi cation of clinical subtypes or standardized diagnostic criteria in veterinary medicine.…”

“…Pyoderma gangrenosum (PG) is a rare inflammatory neutrophilic dermatosis that has been described in humans 1 and dogs 2 3 4 5 6 7 . In humans, PG presents clinically as localized or multifocal, severely painful ulcers with violaceous, undermined margins, typically located on extremities, head and neck 1 .…”