Canine parvovirus 2c infection in a cat with severe clinical disease

Miranda, Carla; Parrish, Colin R.; Thompson, Gertrude

doi:10.1177/1040638714528502

Cited by 38 publications

(38 citation statements)

References 22 publications

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“…Despite the widespread circulation of CPV in Australia, this virus was not detected in any samples tested in these FPL outbreaks. Canine parvovirus causes approximately 5% of FPL cases globally, but these have been confined to sporadic individual cases, and there are no reports of FPL outbreaks caused by CPV in multi-cat environments [8,15,16]. Whether this is due to viral or to host factors is currently unknown and warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

Distinct Lineages of Feline Parvovirus Associated with Epizootic Outbreaks in Australia, New Zealand and the United Arab Emirates

Brussel

Carrai

Lin

et al. 2019

Viruses

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Feline panleukopenia (FPL), a frequently fatal disease of cats, is caused by feline parvovirus (FPV) or canine parvovirus (CPV). We investigated simultaneous outbreaks of FPL between 2014 and 2018 in Australia, New Zealand and the United Arab Emirates (UAE) where FPL outbreaks had not been reported for several decades. Case data from 989 cats and clinical samples from additional 113 cats were obtained to determine the cause of the outbreaks and epidemiological factors involved. Most cats with FPL were shelter-housed, 9 to 10 weeks old at diagnosis, unvaccinated, had not completed a primary vaccination series or had received vaccinations noncompliant with current guidelines. Analysis of parvoviral VP2 sequence data confirmed that all FPL cases were caused by FPV and not CPV. Phylogenetic analysis revealed that each of these outbreaks was caused by a distinct FPV, with two virus lineages present in eastern Australia and virus movement between different geographical locations. Viruses from the UAE outbreak formed a lineage of unknown origin. FPV vaccine virus was detected in the New Zealand cases, highlighting the difficulty of distinguishing the co-incidental shedding of vaccine virus in vaccinated cats. Inadequate vaccination coverage in shelter-housed cats was a common factor in all outbreaks, likely precipitating the multiple re-emergence of infection events.

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Section: Discussionmentioning

confidence: 99%

Distinct Lineages of Feline Parvovirus Associated with Epizootic Outbreaks in Australia, New Zealand and the United Arab Emirates

Brussel

Carrai

Lin

et al. 2019

Viruses

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“…CPV-2a and -2b viruses have been also isolated in feline cells in vitro and in domestic cats in vivo from Japan, USA, Taiwan and Vietnam (Truyen et al, 1995(Truyen et al, , 1996aMochizuki et al, 1996;Ikeda et al, 2000). Diseased cats have also been detected with CPV-2c (Miranda et al, 2014) or co-infections by multiple CPV variants (Battilani et al, 2006) or mixed infections with FPV and CVP-2-like (Url et al, 2003;Battilani et al, 2011). Some studies have also reported the presence of CPV-2 variants in faecal and bone marrow samples of healthy cats (Clegg et al, 2012;Haynes & Holloway, 2012).…”

Section: Host Ranges For Antigenic Cpv-2 Variants Domestic Catsmentioning

confidence: 99%

Canine parvovirus: the worldwide occurrence of antigenic variants

Miranda

Thompson

2016

Journal of General Virology

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“…This variant was subsequently shown to affect adult and immunized dogs, and also cats (Buonavoglia et al 2001, Decaro & Buonavoglia 2012, Miranda et al 2014, quickly spread out and became established in dog populations throughout the world (Cotmore & Tattersall 1996, Buonavoglia et al 2001, Pérez et al 2007, Streck et al 2009, Nandi & Kumar 2010, Parthiban et al 2010. Up to the present, the CPV-2c variant has been detected in high frequencies in many countries.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological, clinical and pathological features of canine parvovirus 2c infection in dogs from southern Brazil

et al. 2018

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Canine parvovirus type 2c (CPV-2c) emerged in Europe in the early 2000’s and rapidly spread out worldwide. Clinical and molecular data have demonstrated its circulation in Brazilian dogs, yet detailed descriptions of cases are still lacking. This article describes the epidemiological, clinical and pathological features of 24 cases of CPV-2c-associated disease in dogs submitted to veterinary clinics and laboratory diagnosis in southern Brazil (2014-2016). Most affected dogs presented signs/lesions suggestive of parvovirus enteritis: diarrhea, vomiting, hyperemia and hemorrhage of the serous membrane of the small intestine, diffuse segmental granulation, atrophy of the villi, necrosis and fusion of crypts, squamous metaplasia and epithelial syncytia. A number of cases presented features divergent from the classical presentations, including a wide variation in the color of feces (reddish and/or yellowish, light-brownish, orange-brown and brownish), involvement of adults (4/24) and vaccinated dogs (12/24), extensive involvement of the small intestine (8/20) and the presence of pulmonary edema (7/24) and convulsions (3/24). Feces and intestinal fragments submitted to PCR for the CPV-2 VP2 gene and to virus isolation in cell culture yielded positive results in 100% and 58.3% (14/24) of the cases, respectively. Nucleotide sequencing revealed a high nucleotide identity in VP2 (99.4 to 100%) and a consistent mutation at amino acid 426 (asparagine to glutamic acid), considered a signature of CPV-2c. These results confirm the involvement of CPV-2c in the described cases and demonstrate the importance of CPV-2c infection among Brazilian dogs, calling attention of veterinarians to correctly diagnose the disease, mainly considering the frequent atypical presentations.

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Canine parvovirus 2c infection in a cat with severe clinical disease

Cited by 38 publications

References 22 publications

Distinct Lineages of Feline Parvovirus Associated with Epizootic Outbreaks in Australia, New Zealand and the United Arab Emirates

Distinct Lineages of Feline Parvovirus Associated with Epizootic Outbreaks in Australia, New Zealand and the United Arab Emirates

Canine parvovirus: the worldwide occurrence of antigenic variants

Epidemiological, clinical and pathological features of canine parvovirus 2c infection in dogs from southern Brazil

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