Canine parvovirus: the worldwide occurrence of antigenic variants

Miranda, Carla; Thompson, Gertrude

doi:10.1099/jgv.0.000540

Cited by 171 publications

(209 citation statements)

References 117 publications

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“…Canine parvovirus has still been playing a main role in inducing severe and often fatal gastroenteritis in young or non‐immunized dogs. During years, CPV spread and evolution have been well documented in North and South America, Europe and Asia (Miranda & Thompson, ; Zhou, Zeng, Zhang, & Li, ). More recently, data about its spread were also obtained from Australia and Africa (Amrani et al, ; Castanheira et al, ; Chollom et al, ; Dogonyaro et al, ; Figuiredo et al, ; Folitse et al, ; Kapiya et al, ; Touhiri et al, ; Woolford et al, ).…”

Section: Discussionmentioning

confidence: 99%

Nearly full‐length genome characterization of canine parvovirus strains circulating in Nigeria

Ogbu

Mira

Purpari

et al. 2019

Transbound Emerg Dis

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Canine parvovirus type 2 (CPV‐2) emerged suddenly in the late 1970s as pathogen of dogs, causing a severe and often fatal gastroenteric disease. The original CPV‐2 was replaced by three antigenic variants, CPV‐2a, CPV‐2b and CPV‐2c, which to date have gained a worldwide distribution with different relative proportions. All previous studies conducted in Africa were based on partial VP2 gene sequences. The aim of this study was to provide a genome analysis to characterize the CPV strains collected in Nigeria, Africa. Rectal swab samples (n = 320) were collected in 2018 and tested by means of an immunochromatographic assay. Among the 144 positive samples, 59 were selected for further analyses using different molecular assays. The results revealed a high prevalence of CPV‐2c (91.5%) compared to the CPV‐2a variant (8.5%). The VP2 gene sequences showed a divergence from the strains analysed in 2010 in Nigeria and a closer connection with CPV strains of Asian origin. The non‐structural gene analysis evidenced amino acid changes never previously reported. The molecular analysis based on genomic sequences evidenced a geographical pattern of distribution of the analysed strains, suggesting a potential common evolutionary origin with CPV of Asian origin. This study represents the first CPV molecular characterization including all the encoding gene sequences conducted in the African continent and contributes to define the current geographical spread of the CPV variants worldwide.

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Section: Discussionmentioning

confidence: 99%

Nearly full‐length genome characterization of canine parvovirus strains circulating in Nigeria

Ogbu

Mira

Purpari

et al. 2019

Transbound Emerg Dis

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“…The oldest CPV‐2c sequence was obtained from a wildcat in 2001; this is five years after the first report of CPV‐2c in the literature (Decaro, Desario, et al, ), and 5 years before the first detection of CPV‐2c in Spain (Decaro et al, ). CPV‐2c appears to be the most recent clade of carnivore parvoviruses (Miranda & Thompson, ) and it might replace older clades in Spanish wild ecosystems.…”

Section: Discussionmentioning

confidence: 99%

Genetic characterization of Carnivore Parvoviruses in Spanish wildlife reveals domestic dog and cat‐related sequences

Calatayud

Esperón²,

Velarde

et al. 2019

Transbound Emerg Dis

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The impact of carnivore parvovirus infection on wild populations is not yet understood; disease signs are mainly developed in pups and assessing the health of litters in wild carnivores has big limitations. This study aims to shed light on the virus dynamics among wild carnivores thanks to the analysis of 213 samples collected between 1994 and 2013 in wild ecosystems from Spain. We determined the presence of carnivore parvovirus DNA by real‐time PCR and sequenced the vp2 gen from 22 positive samples to characterize the strains and to perform phylogenetic analysis. The presence of carnivore parvovirus DNA was confirmed in 18% of the samples, with a higher prevalence detected in wolves (Canis lupus signatus, 70%). Fourteen sequences belonging to nine wolves, three Eurasian badgers (Meles meles), a common genet (Genetta genetta) and a European wildcat (Felis silvestris) were classified as canine parvovirus 2c (CPV‐2c); five sequences from three wolves, a red fox (Vulpes vulpes) and a stone marten (Martes foina) as CPV‐2b; and three sequences from a badger, a genet and a stone marten as feline parvovirus (FPV). This was the first report of a wildcat infected with a canine strain. Sequences described in this study were identical or very close related to others previously found in domestic carnivores from distant countries, suggesting that cross‐species transmission takes place and that the parvovirus epidemiology in Spain, as elsewhere, could be influenced by global factors.

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“…Six of these samples, where longer PCR products were obtained, were definitively CPV-2a, the remaining nine for which only short sequences were obtained were CPV-2 or CPV-2a. However, as CPV-2 is not considered to have circulated since its replacement by CPV-2a worldwide in the 1980s and detection of vaccine strains even in dogs recently vaccinated does not commonly occur (Miranda and Thompson 2016a, b), it is very likely that these are CPV-2a. The only other residue that differed from the reference CPV-2a sequence in the longer PCR products (Table 3) has been reported in isolates from other countries previously (Yoon and others 2009).…”

Section: Discussionmentioning

confidence: 99%

Canine parvovirus (CPV‐2) variants circulating in Nigerian dogs

Apaa

Daly

Tarlinton

2016

Veterinary Record Open

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Canine parvovirus type 2 (CPV-2) is a highly contagious viral disease with three variants (CPV-2a, CPV-2b and CPV-2c) currently circulating in dogs worldwide. The main aim of this study was to determine the prevalent CPV-2 variant in faecal samples from 53 dogs presenting with acute gastroenteritis suspected to be and consistent with CPV-2 to Nigerian Veterinary Clinics in 2013–2014. Seventy-five per cent of these dogs tested positive for CPV-2 in a commercial antigen test and/or by PCR. Partial sequencing of the VP2 gene of six of these demonstrated them to be CPV-2a. Most of the dogs (60 per cent) were vaccinated, with 74 per cent of them puppies less than six months old.

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Canine parvovirus: the worldwide occurrence of antigenic variants

Cited by 171 publications

References 117 publications

Nearly full‐length genome characterization of canine parvovirus strains circulating in Nigeria

Nearly full‐length genome characterization of canine parvovirus strains circulating in Nigeria

Genetic characterization of Carnivore Parvoviruses in Spanish wildlife reveals domestic dog and cat‐related sequences

Canine parvovirus (CPV‐2) variants circulating in Nigerian dogs

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